EFFECTS OF A 28-DAY SUSTAINED-RELEASE FORMULATION OF RECOMBINANT BOVINE SOMATOTROPIN (rbST) ADMINISTERED TO COWS OVER TWO CONSECUTIVE LACTATIONS

Léonard, Martin; Gallo, M.; Gallo, G.; Block, E.

doi:10.4141/cjas90-099

Cited by 18 publications

(9 citation statements)

References 7 publications

(9 reference statements)

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“…Structurefunction diversity for bovine GH has also been implied by studies which have detected point mutations in the bovine GH molecule (Lucy et al 1993). Molecular genetic studies have confirmed that considerable polymorphism exists in the gene that encodes bovine GI{ (Cowan et al 1989;Theilmann et al 1989;Kirkpatrick1992 Rocha et al 1992Zhanget al 1993) and studies designed to determine GH genotype-production associations have been initiated (Hilbert et al 1989;Hoj et al 1993;Lucy et al 1993 (Bauman et al 1989a;Oldenbroek et al 1989;L6onard et al 1990). Regardless ofthe potential for cyclical milk response over multiple sustained release injection periods, average lactational milk yield increases of 10-15% are reported in response to this form of rbGH.…”

Section: Production Performance Of Dairy Cows Treated With Growth mentioning

confidence: 98%

“…Growing heifers show lesser insulin resistance and lower milk yield responses to rbGH than multiparous cows (Chilliard 1988) (Gallo 1989;Gallo and Block 1990a) (Fig. 3), it also appears to allow overall adaptation of metabolism such that the incidence of ketosis and liver disease does not increase (reviewed by McBride et al 1988;Burton and McBride 1989;Chilliard 1989 Elvinger et al 1988;Cleale et al 1989;Hansen et al 1989;McDaniel et al 1989;Burton et al 1990b;Gibson et al 1990), increased number of services per conception (by 0.5-1), and a lower conception rate (by 5-10%) in rbGHtreated versus control cows Huber et al 1988;L6onard et al 1990). These trends were especially noticeable when higher doses (> 40 mg d-') of rbGH were used (Thomas et al 1987), but were not statistically significant perhaps due to the limited number of cows and the large variation among treatment groups in these individual trials.…”

Section: Effects Of Growth Hormone On Body Conditionmentioning

confidence: 99%

“…The period of minimum body condition for rbGH-treated cows is longer than for control cows, which have lower milk yields (L6onard et al 1990). Once cows return to positive energy balance, body condition is regained to the extent that original condition is restored prior to peak production in the subsequent lactation (Soderholm et al 1988;Gallo and Block 1990b;L6onard et al 1990). Increased feed intake relative to controls in midand late treatment periods @urton et al.…”

Section: Effects Of Growth Hormone On Body Conditionmentioning

confidence: 99%

“…1992;vanden Berg 1991;Baumanlgg2;Lynchet al1992 Chalupa and Galligan 1989;van den Berg 1989;L6onard et al 1990;Bauman and Vernon 1993 For personal use only.…”

Section: Production Performance Of Dairy Cows Treated With Growth mentioning

confidence: 99%

“…Once cows return to positive energy balance, body condition is regained to the extent that original condition is restored prior to peak production in the subsequent lactation (Soderholm et al 1988; Gallo and Block 1990b;L6onard et al 1990). Increased feed intake relative to controls in midand late treatment periods @urton et al 1990a), and probably during the dry period and pretreatment period of the subsequent lactation , must contribute to the regain of body condition in rbGH-treated cows.…”

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confidence: 99%

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A review of bovine growth hormone

Burton¹,

McBride²,

Block³

et al. 1994

Can. J. Anim. Sci.

132

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. 74: 16'7-201. Unprecedented numbers of technical papers, abstracts, and short communications have been published in the past decade regarding the effects of exogenous bovine growth hormone on milk production, health, and reproductive efficiency of treated dairy cows. In well-managed dairy herds, exogenous growth hormone increases milk production without altering normal variability in milk composition. This has held true regardless of dairy breed tested, geographical location studied, or feeding management system used. Also consistent across studies is the rapidity of the galactopoietic effect of administered bovine growth hormone, which arises from altered partitioning and use of post-absorptive nutrients and increased synthetic capacity of the mammary gland. Growth hormone and its associated peptide, insulin-like growth factor-I, are now known to provide chronic lipolytic, diabetogenic, and gluconeogenic signals to target tissues culminating in increased mammary gland availability of glucose and nonesterified fatty acids. Together with yet ill-defined effects on mammary secretory tissue, this homeorhetic control of metabolism elicited by exogenous growth hormone is so efficient that treated cows are not more susceptible to metabolic disorders than untreated cows. However, some studies have reported an increased frequency of mastitis in groups of treated cows. This has been attributed mainly to increased milk volume in the mammary glands of treated cows and no convincing data are available that show decreased mammary gland immunity as a result of growth hormone treatments. On the contrary, an expanding body of evidence implicates growth hormone as a key neuroendocrine factor that is required for immunological competence. Trends of decreased reproductive efficiency in cows treated with growth hormone have also been reported, but available data imply that this is probably an indirect effect via prolonged negative energy balance in cows treated in early lactation rather than a direct negative effect on estrous cycling via altered reproductive hormone profiles. The objectives of the present review are to bring into focus and summarize pertinent biological discoveries regarding the treatment of dairy cows with recombinant bovine growth hormone, and to explore areas where additional growth hormone research is needed or warranted.Key words: Growth hormone, somatotropin, dairy cows, insulin-like growth factor-I Burton, J. L., McBride, B. W., Block, E., Glimm, D. et Kennelly,E. 1994. L'horrnone de croissance bovinemais au point bibliographique. Can. J. Anim. Sci. 74: . D'innombrables m6moires techniques, r6sum6s analytiques et communications brdves ont 6t6 publi6s dans la dernidre d6cennie au sujet des effets de I'hormone de croissance bovine exogdne sur la production laitidre, sur la sant6 et sur les fonctions de reproduction des vaches laitidres trait6es. Dans les 6levages laitiers bien conduits, la GH exogbne accroit la production de lait sans modifier la variabilit6 normale de sa composition, et cela inddpendamme...

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Section: Production Performance Of Dairy Cows Treated With Growth mentioning

confidence: 98%

Section: Effects Of Growth Hormone On Body Conditionmentioning

confidence: 99%

Section: Effects Of Growth Hormone On Body Conditionmentioning

confidence: 99%

“…1992;vanden Berg 1991;Baumanlgg2;Lynchet al1992 Chalupa and Galligan 1989;van den Berg 1989;L6onard et al 1990;Bauman and Vernon 1993 For personal use only.…”

Section: Production Performance Of Dairy Cows Treated With Growth mentioning

confidence: 99%

mentioning

confidence: 99%

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A review of bovine growth hormone

Burton¹,

McBride²,

Block³

et al. 1994

Can. J. Anim. Sci.

132

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Recombinant Growth Hormone: Potential Interest and Risks of its Use in Bovine Milk Production

Chilliard¹,

Lerondelle²,

Disenhaus³

et al.

Focus on Biotechnology

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Effect of two formulations of recombinant bovine somatotropin on milk production and body condition of cattle under intensive management in Peru

Gómez

Fernández

Franco³

et al. 2022

Trop Anim Health Prod

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The effect of recombinant somatotropin (rbST) application in cattle has been demonstrated in temperate climate but very limited studies are available in tropical regions. The objective of this study was to compare the effect of the application of two different formulations of rbST on the milk yield and body condition of dairy cattle in a commercial herd under intensive production in Peru. We evaluated the application of 500 mg of active rbST in a zinc sesame oil (ZSO-rbST; n = 44) or vitamin E lecithin (VEL-rbST; n = 45) vehicle while control cows (n = 42) did not receive any application. The application of rbST was performed by every 14 days for 12 cycles, for a total of 168 days. The application of rbST increased the milk production of primiparous and multiparous cows by 3 and 3.2 kg/day for the VEL-rbST formulation respectively when compared with control cows (p < 0.01) and no difference in milk production was observed between the ZSO-rbST formulation and the control group (p > 0.05). However, no significant difference on milk production was observed between the rbST formulations evaluated. The effect of rbST per injection cycle indicated differences in milk production and economic return for the 12 cycles between rbST and control in primiparous group, while in multiparous, no differences were found between ZSO-rbST and control (p > 0.05), but differences were observed between VEL-rbST and control in 41% of the cycles (p < 0.05). No differences in body condition were found between the two rbST formulations and the control group during the evaluation. In conclusion, the application of rbST promoted higher milk production of cattle which had a positive impact on the economic income of the farmer.

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EFFECTS OF A 28-DAY SUSTAINED-RELEASE FORMULATION OF RECOMBINANT BOVINE SOMATOTROPIN (rbST) ADMINISTERED TO COWS OVER TWO CONSECUTIVE LACTATIONS

Abstract: LBoNano, M., Gnllo, M., Gallo, G. eNt Br-ocr, E. 1990. Effects of a28-day sustained-release formulation of recombinant bovine somatotropin (rbST)

Cited by 18 publications

References 7 publications

A review of bovine growth hormone

A review of bovine growth hormone

Recombinant Growth Hormone: Potential Interest and Risks of its Use in Bovine Milk Production

Effect of two formulations of recombinant bovine somatotropin on milk production and body condition of cattle under intensive management in Peru

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