Effects of a 1‐year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children

Abstract

Objective: Exercise improves weight status and metabolism. Irisin, a novel myokine, may be involved in the regulation of metabolic function. The effect of an exercise and dietary lifestyle intervention for 1-year on irisin, adipokines (leptin, adiponectin, resistin) and inflammatory markers (C-reactive protein (CRP), soluble tumor necrosis factor receptor II (sTNFR-II) was evaluated, and predictors of irisin levels were characterized in obese children. Methods: Parameters were assessed at baseline and at follow-up for 65 obese children who completed the program (7-18 years, 54%boys). Their relation to weight status and metabolic risk was analyzed. Results: Anthropometric and metabolic parameters improved after completion of the program. Circulating irisin levels at baseline were 111.0 6 8.0 ng ml 21 and increased after the intervention by 12% [6%, 17%], P 5 0.00003. There was no evidence for differences in irisin levels between genders and across age. Moreover, changes in irisin did not correlate with those in BMI-SDS, adipokines or inflammatory markers. Leptin decreased after the intervention (D5.3 ng ml ). Anthropometric measures were significantly associated with leptin and inflammatory markers. Conclusions: A 1-year long lifestyle intervention program is associated with improvement in anthropometric and metabolic parameters and leads to an elevation in irisin levels in obese children.

Physical Exercise Induces Irisin Levels Associated With Improved Cognitive Functions and Glucose Tolerance in Obese and Normal Weight Egyptian Subjects: A 3-Month Interventional Study.

“…Adopting aerobic exercise for 3-months significantly induced irisin levels in both control and obese groups. Our results corroborated with those of Boström et al 5 and Bluher et al 44 who reported increased irisin levels after 10 weeks and 1 year of physical exercise, respectively. The exerciseinduced irisin levels in our studies were significantly correlated with improved cognitive functions after controlling for confounding factors that could affect cognitive process.…”

Adiponectin, Inflammation and Cardiometabolic Risk Factors in Paediatric Obese Patients: Impact of Interventional Studies

“…By contrast, other authors did not find any correlation between adiponectin and leptin [10,14,96] in OW and OB children, despite the association of both adipokines with IR and adiposity.…”

“…In children, HMW adiponectin multimer is usually linked to an improvement in insulin resistance (IR) and lipid profile [6], and it has been negatively associated with cardiometabolic complications [8]. The negative associations of HMW adiponectin with IR and adiposity appear to be present even in pre-pubertal (PP) individuals [9,10]. Zimmet et al reported that in PP children, HMW adiponectin was negatively associated with body mass index (BMI) z-score, IR, triglycerides (TG), leptin and soluble intracellular adhesion molecule (sICAM); however, after adjustment for age and sex, only BMI z-score and TG maintained their negative association with HMW adiponectin [11].…”

“…Total adiponectin levels are negatively correlated with IR, and the increase in adiponectin, following a lifestyle intervention, leadvvvs to a decrease in IR [29,73]. However, there is still some controversy concerning this association [10].…”

Effects of a multi-component camp-based intervention on inflammatory markers and adipokines in children: A randomized controlled trial

“…In an RCT study, Balagopal et al (2010) found a reduction in leptin and increase in soluble leptin receptor in obese children after a 3-month lifestyle intervention (physical activity, caloric restriction and limiting TV time). In an intervention study in obese children, Bluher et al (2014) found that leptin decreased after a one-year lifestyle intervention (physical activity and educational classes for parents) compared with baseline. In the current study, we did not find intervention effects on leptin at 52-week follow-up.…”