Effects of 6-h exposure to low relative humidity and low air pressure on body fluid loss and blood viscosity

Hashiguchi, Nobuko; Takeda, Akira; Yasuyama, Yukari; Chishaki, Akiko; Tochihara, Yutaka

doi:10.1111/ina.12039

Cited by 21 publications

(11 citation statements)

References 33 publications

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“…The effect of air pressure (altitude) and RH was studied in 14 young healthy subjects that were exposed for six hours to 10% and 60% RH at different air pressures (sea level and 2000 m altitude), independently. Low pressure increased body fluid loss, which was exacerbated by low RH . Thus, it is fair to conclude that low pressure enhances TE and causes hyperosmolarity and reduced BUT as demonstrated by Willmann et al .…”

Section: Resultsmentioning

confidence: 78%

External eye symptoms in indoor environments

Wolkoff

2016

Indoor Air

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Eye irritation, for example dry or irritated eyes, is generally among top three reported symptoms in office-like environments, in particular among workplaces with cognitive demanding visual display unit (VDU) work. The symptoms are especially among middle and advanced ages and particularly among women more than men. The symptoms are also among the most commonly reported complaints in the eye clinic. To be in a position to interpret the high prevalence of eye symptoms, a multidisciplinary and integrated approach is necessary that involves the external eye physiology (separate from internal eye effects), eye diseases (evaporative dry eye (DE), aqueous-deficient DE, and gland dysfunctions), and risk factors that aggravate the stability of precorneal tear film (PTF) resulting in hyperosmolarity and initiation of inflammatory reactions. Indoor environmental, occupational and personal risk factors may aggravate the PTF stability; factors such as age, contact lenses, cosmetics, diet, draft, gender, low humidity and high temperature, medication, outdoor and combustion pollutants, and VDU work.Psychological stressors may further influence the reporting behavior of eye symptoms.The impact of the risk factors may occur in a combined and exacerbating manner. The symptoms are also among the most commonly reported complaints in the eye clinic, 8 and dry eye disease (DED) is the most common cause of chronic eye irritation in patients over age of 50. 9,10 These external symptoms, as opposed to internal symptoms such as tired or strained eyes (asthenopia) as already described by Dante in 1304-1307, 11 are categorized as dry eye (DE)-like symptoms.12 The symptoms are especially among middle and advanced ages throughout the world and expected to increase due to visually highly demanding workplaces increase continuously and so does the average age of the workforce.Indoor air pollution and low relative humidity (RH) have been proposed to explain the external DE symptoms; furthermore, a number of occupational and personal risk factors have been suggested to exacerbate the symptom reporting. 13 For instance, high ozone concentrations, especially in aircraft, have been proposed to initiate both gas (homogeneous) and surface (heterogeneous) reactions with reactive substances to produce a complex host of gas-and particle-phase products, for example formaldehyde. 14-16 The key question in search of causality for DE symptoms in office workers is how important indoor air pollution is in comparison with occupational, environmental, and personal risk factors. For instance, reported DE symptoms among young and middle-aged Japanese office workers were significantly higher among those with clinically diagnosed DED (12%) than in those with probable (54%) or undiagnosed DED (34%);

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Section: Resultsmentioning

confidence: 78%

External eye symptoms in indoor environments

Wolkoff

2016

Indoor Air

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“…In our analysis, lower relative morning humidity was found to be associated with increased rate of hospital admission for aneurysmal subarachnoid hemorrhage. One study found that decreased relative humidity and air pressure increase insensible water loss and blood viscosity [37] . Arterial wall shear stress is directly proportional to velocity of blood flow and blood viscosity, potentially increasing the risk of aneurysm rupture.…”

Section: Discussionmentioning

confidence: 99%

The Association between Meteorological Parameters and Aneurysmal Subarachnoid Hemorrhage: A Nationwide Analysis

Lai

Dasenbrock

2014

PLoS ONE

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Prior research has suggested that regional weather patterns impact the risk of rupture of cerebral aneurysms, but the findings in the literature have been inconsistent. Furthermore, no nationwide analysis to date has examined the association between meteorological factors and the post-procedural outcomes of patients after the treatment for ruptured cerebral aneurysms. The purpose of this study was to use a nationwide sample to analyze the association between specific meteorological parameters—temperature, precipitation, sunlight, and humidity—and hospital admission rate for and outcome after aneurysmal subarachnoid hemorrhage. Patients were identified using the Nationwide Inpatient Sample (2001–2010): Those with an ICD-9 diagnosis code for subarachnoid hemorrhage and a procedural code for aneurysm repair were included. Climate data were obtained from the State of the Climate Report 2010 released by the National Climatic Data Center. Multivariate regression models were constructed to analyze the association between average state monthly temperature, precipitation, and percent possible sunlight, as well as relative morning humidity and both monthly hospital admission rate, adjusted for annual state population in millions, and in-hospital mortality. 16,970 admissions were included from 723 hospitals across 41 states. Decreased daily sunlight and lower relative humidity were associated with an increased rate of admission for ruptured cerebral aneurysms (p<0.001), but had no association with differential inpatient mortality. No significant changes in these observed associations were seen when multivariate analyses were constructed. This is the first nationwide study to suggest that decreased sunlight and lower relative humidity are associated with admission for ruptured cerebral aneurysms. While it has been postulated that external atmospheric factors may cause hormonal and homeostatic changes that impact the risk of rupture of cerebral aneurysms, additional research is needed to confirm and further understand these relationships.

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“…Looking at the results of the 45 new studies, at least two measurements were performed in 14 [18][19][20][21][22][23][24][25][26][27][28][29][30][31] of the 45 studies, and the TEWL devices were calibrated prior to the study in four. [31][32][33][34] Avoidance of air turbulence was reported in five 18,19,31,34,35 of the 45 studies.…”

Section: Study Selection and Study Characteristicsmentioning

confidence: 99%

Transepidermal water loss in healthy adults: a systematic review and meta-analysis update

et al. 2018

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Reference estimates are useful for clinical study planning and interpretation of results. TEWL is highly dependent on skin area, and our results further support the symmetry between right and left measuring sites. TEWL in elderly people seems to be generally similar or decreased compared with younger individuals, but available evidence is limited. Reporting of TEWL should be improved: mean and spread parameters should always be reported in future studies.

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Effects of 6-h exposure to low relative humidity and low air pressure on body fluid loss and blood viscosity

Cited by 21 publications

References 33 publications

External eye symptoms in indoor environments

External eye symptoms in indoor environments

The Association between Meteorological Parameters and Aneurysmal Subarachnoid Hemorrhage: A Nationwide Analysis

Transepidermal water loss in healthy adults: a systematic review and meta-analysis update

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