Effects of 5-HT3 receptor antagonists on neuroleptic-induced catalepsy in mice

Silva, S.R.; Futuro-Neto, H. A.; Pires, J.G.P.

doi:10.1016/0028-3908(94)00146-j

Cited by 26 publications

(18 citation statements)

References 16 publications

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“…Catalepsy was induced with haloperidol (1 mg/kg, ip) and determined at 30-min intervals by means of a standard bar test (3,16). This dose of haloperidol was chosen to produce a moderate degree of catalepsy so that inhibition or potentiation of catalepsy could be detected (1,16).…”

Section: Methodsmentioning

confidence: 99%

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Gender-related differences in the effects of nitric oxide donors on neuroleptic-induced catalepsy in mice

Pires

Costa

Saraiva

et al. 2003

Braz J Med Biol Res

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It has been suggested that nigrostriatal dopaminergic transmission is modulated by nitric oxide (NO). Since there is evidence that gonadal hormones can affect extrapyramidal motor behavior in mammals, we investigated the effects of isosorbide dinitrate (ISD), linsidomine (SIN-1) and S-nitroso-N-acetylpenicillamine (SNAP), three pharmacologically different NO donors, on neuroleptic-induced catalepsy in 60-to 80-day-old male and female albino mice. Catalepsy was induced with haloperidol (1 mg/kg, ip) and measured at 30-min intervals by means of a bar test. Drugs (or appropriate vehicle) were injected ip 30 min before haloperidol, with each animal being used only once. ISD (5, 20 and 50 mg/kg) caused a dose-dependent inhibition of catalepsy in male mice (maximal effect 120 min after haloperidol: 64% inhibition). In the females only at the highest dose of ISD was an attenuation of catalepsy observed, which was mild and short lasting. SIN-1 (10 and 50 mg/kg) did not significantly affect catalepsy in female mice, while a significant attenuation was observed in males at the dose of 50 mg/kg (maximal inhibition: 60%). SNAP (20 mg/kg) significantly attenuated catalepsy in males 120 min after haloperidol (44% inhibition), but had no significant effect on females. These results basically agree with literature data showing that NO facilitates central dopaminergic transmission, although the mechanisms are not fully understood. They also reveal the existence of gender-related differences in this nitrergic modulation in mice, with females being less affected than males. Correspondence

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Section: Methodsmentioning

confidence: 99%

“…Neuroleptic-induced catalepsy in rodents is a robust behavioral method for studying nigrostriatal dopaminergic function and its modulation by other transmitter systems (1)(2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

Gender-related differences in the effects of nitric oxide donors on neuroleptic-induced catalepsy in mice

Pires

Costa

Saraiva

et al. 2003

Braz J Med Biol Res

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“…[28][29][30] Recent clinical studies also showed that ondansetron significantly reduced the incidence and severity of antipsychotic-induced EPS (e.g., akathisia and parkinsonism) in patients with chronic schizophrenia. 31,32) In our studies, activation of the serotonergic system by 5-hydroxytryptophan (5-HTP) significantly potentiated haloperidol-induced catalepsy and this 5-HTPpotentiated EPS was also suppressed by systemic treatments or intrastriatal microinjections of ondansetron.…”

Section: -Htmentioning

confidence: 99%

Pathophysiological Roles of Serotonergic System in Regulating Extrapyramidal Motor Functions

Ohno

Shimizu

Tokudome

2013

Biological & Pharmaceutical Bulletin

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The serotonergic nervous system plays crucial roles in regulating psycho-emotional, cognitive, sensorimotor and autonomic functions. It is now known that multiple serotonin (5-hydroxytryptamine; 5-HT) receptors regulate extrapyramidal motor functions, which are implicated in pathogenesis and/or treatment of various neurological disorders (e.g., Parkinson's disease and drug-induced extrapyramidal motor deficits).

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“…antagonists are reported to diminish neuroleptic-induced catalepsy. 4 Hence ondansetron, a 5-HT3 antagonist was used as standard drug in this study to compare the anticataleptic effect of the test compound, piperine.…”

Section: 2mentioning

confidence: 99%

Evaluation of the effect of piperine per se and its interaction with ondansetron on haloperidol induced catalepsy in Albino mice

Mishra

Tiwari

et al. 2018

Int J Basic Clin Pharmacol

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Background: This study aims to evaluate the per se effect of piperine and its interaction with ondansetron on haloperidol induced catalepsy in swiss albino mice.Methods: The piperine crystals were separated from crude extract of Piper nigrum. Catalepsy was induced by haloperidol (1mg/kg, i.p.). Control group received 2% gum acacia (10ml/kg), standard group ondansetron (0.5mg/kg), test group piperine (10mg/kg) and combination group ondansetron plus piperine (0.5mg/kg + 10mg/kg), per oral, respectively. In acute study, drugs were administered only once, one hour prior to the haloperidol administration. Whereas in chronic study, catalepsy was determined on the seventh day of treatment.Results: In acute study, from 60 min onwards after haloperidol administration, ondansetron and ondansetron plus piperine group resulted in significantly lower cataleptic scores than the control treated group. On the other hand, 120 min onwards ondansetron group showed significantly lower cataleptic scores (24.62) as compared to the ondansetron plus piperine group (31.50). In the chronic study, from 60 min onwards, ondansetron and the ondansetron plus piperine resulted in significantly lower cataleptic scores than the control treated group. Also the combination of ondansetron plus piperine was more significantly protective compared to ondansetron alone (P <0.05).Conclusions: Piperine has the potential to be used as a bioenhancer when combined with other drugs which would reduce the dose of drugs and thereby adverse effects. It may act probably by enhancing the bioavailability as well as by inhibiting the metabolic pathways of other drugs.

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Effects of 5-HT3 receptor antagonists on neuroleptic-induced catalepsy in mice

Cited by 26 publications

References 16 publications

Gender-related differences in the effects of nitric oxide donors on neuroleptic-induced catalepsy in mice

Gender-related differences in the effects of nitric oxide donors on neuroleptic-induced catalepsy in mice

Pathophysiological Roles of Serotonergic System in Regulating Extrapyramidal Motor Functions

Evaluation of the effect of piperine per se and its interaction with ondansetron on haloperidol induced catalepsy in Albino mice

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