Effects of 5′-Adenosine Triphosphate on Intestinal Ischemia-Reperfusion in Rabbits

Taha, Murched Omar; Miranda-Ferreira, Regiane; Fagundes, Djalma José; Simões, Ricardo Santos; Monteiro, Hugo P.; Oliveira, Indhira Dias; Soares, Katelyn; Martins, Maria Cristina; Balbino, A.T.; Rodrigues, Fabrício Á.; Arruda, Thais Bonato de; Abrão, Marianne Sales; Jurkiewicz, Aron; Caricati‐Neto, Afonso

doi:10.1016/j.transproceed.2010.01.036

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…ATP-MgCl 2 reduces intestinal permeability during mesenteric ischemia (Kreienberg et al, 1996). Both adenosine and ATP were reported to attenuate intestinal dysfunction produced by ischemia but not that caused by reperfusion (Taha et al, 2010a(Taha et al, , 2010b. A more recent study showed that treatment with adenosine attenuated small bowel motor and neural malfunctions produced by ischemia and reperfusion in rats (Haddad et al, 2012).…”

Section: Ischemiamentioning

confidence: 99%

Purinergic Signaling and Blood Vessels in Health and Disease

2013

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Section: Ischemiamentioning

confidence: 99%

Purinergic Signaling and Blood Vessels in Health and Disease

2013

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“…For example, adenosine acts via both A 2A and A 2B receptors, and A 2A receptors provide potential protection and is a novel therapeutic target for intestinal ischaemia-reperfusion injury [180,203,314]. ATP attenuated intestinal dysfunction produced by ischaemia, but not that caused by reperfusion in rabbits [650]. In ischaemia-reperfusion of the intestine, there was a decrease in P2X2 receptor expression in the myenteric and submucosal plexus [545].…”

Section: Ischaemiamentioning

confidence: 99%

Purinergic signalling in the gastrointestinal tract and related organs in health and disease

Burnstock

2013

Purinergic Signalling

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Purinergic signalling plays major roles in the physiology and pathophysiology of digestive organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive intestinal peptide, is a cotransmitter in nonadrenergic, non-cholinergic inhibitory neuromuscular transmission. P2X and P2Y receptors are widely expressed in myenteric and submucous enteric plexuses and participate in sympathetic transmission and neuromodulation involved in enteric reflex activities, as well as influencing gastric and intestinal epithelial secretion and vascular activities. Involvement of purinergic signalling has been identified in a variety of diseases, including inflammatory bowel disease, ischaemia, diabetes and cancer. Purinergic mechanosensory transduction forms the basis of enteric nociception, where ATP released from mucosal epithelial cells by distension activates nociceptive subepithelial primary afferent sensory fibres expressing P2X3 receptors to send messages to the pain centres in the central nervous system via interneurons in the spinal cord. Purinergic signalling is also involved in salivary gland and bile duct secretion.

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Increased sympathoexcitatory reflex induced by myocardial ischemic nociceptive signaling via P2X2/3 receptor in rat superior cervical ganglia

Liu

Zhang

et al. 2010

Neurochemistry International

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Effects of 5′-Adenosine Triphosphate on Intestinal Ischemia-Reperfusion in Rabbits

Cited by 4 publications

References 9 publications

Purinergic Signaling and Blood Vessels in Health and Disease

Purinergic Signaling and Blood Vessels in Health and Disease

Purinergic signalling in the gastrointestinal tract and related organs in health and disease

Increased sympathoexcitatory reflex induced by myocardial ischemic nociceptive signaling via P2X2/3 receptor in rat superior cervical ganglia

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