Effects of 3D image-guided brachytherapy compared to 2D conventional brachytherapy on clinical outcomes in patients with cervical cancer: A systematic review and meta-analyses

Suzumura, Érica Aranha; Gama, Layse Martins; Jahn, Beate; Campolina, Alessandro Gonçalves; Carvalho, Heloísa de Andrade; Soárez, Patrícia Coelho de

doi:10.1016/j.brachy.2021.03.004

Cited by 18 publications

(21 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Though IGBT confers excellent results [3,15,48], there is only one ongoing randomized trial comparing point-A and volumebased BT outcomes [16]. It is unlikely that level 1 evidence supporting IGBT will be accessible soon.…”

Section: Discussionmentioning

confidence: 99%

“…Improvement in OS was not demonstrable. Suzumura et al [15] conducted a metaanalysis with twenty studies demonstrating superior OS (HR 0.78, 95% CI 0.62-0.98), LC (HR 0.77, 95% CI 0.59-0.99), pelvic disease-free survival (HR 0.75, 95% CI 0.62-0.90), and lower grade 3-4 overall [9% lower, 95% CI 6% À 11%) and gastrointestinal toxicities (5% lower, 95% CI 2% À 8%) for 3D-BT. Metastasis-free survival and genitourinary toxicity demonstrated no differences.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a multi-centric prospective cohort study reported 5-year LC of 92% (95% CI 90%-93%) and 5-year DFS of 68% (95% CI 65%-70%) [3]. A meta-analysis reported superior overall survival [HR 0.78 (95%CI 0.62-0.98)] and pelvic disease-free survival [HR of 0.75 (95%CI 0.62-0.90)], with lower toxicities for IGBT, compared to point-A BT [15].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Point-A vs. volume-based brachytherapy for the treatment of cervix cancer: A meta-analysis

Hande

Chopra

Kalra

et al. 2022

Radiotherapy and Oncology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Point-A vs. volume-based brachytherapy for the treatment of cervix cancer: A meta-analysis

Hande

Chopra

Kalra

et al. 2022

Radiotherapy and Oncology

View full text Add to dashboard Cite

“…With the application of imaging technologies such as CT and magnetic resonance imaging (MRI) in brachytherapy, the dosimetry of 3D brachytherapy is significantly improved compared with traditional 2D brachytherapy [15,16]. e 3D brachytherapy planning system used in this study was Oncentra Brachy V4.1, which can be designed using manual planning (GO) or IPSA.…”

Section: Discussionmentioning

confidence: 99%

Optimizing the IPSA Conditions to Improve the Treatment Plan Quality in Brachytherapy for Cervical Cancer

Yang

Cai

et al. 2022

Journal of Oncology

View full text Add to dashboard Cite

Recent prevalent use of three-dimensional image-guided brachytherapy (3D brachytherapy) has dramatically improved the treatment outcomes of cervical cancer. Inverse planning simulated annealing (IPSA) is one of the commonly used algorithms in 3D brachytherapy, but different conditions may affect the treatment plan quality. In this study, we compared HRCTV (high-risk clinical target volume) D90 (dose prescription) and HRCTV D95 D2cc (dose received by 2.0cc) of the rectum, bladder, and sigmoid in 30 patients with cervical cancer under four IPSA conditions. The HRCTV D90 (mean ± SD cGy) was 607.32 ± 37.86, 599.01 ± 23.62, 598.67 ± 13.07, and 596.45 ± 10.94 in four groups, respectively. The HRCTV D95 was 558.19 ± 38.51, 558.17 ± 25.72, 557.03 ± 16.12, and 555.26 ± 12.78, respectively. The sigmoid D2cc was 282.96 ± 44.84, 273.14 ± 60.69, 268.94 ± 62.32, and 292.69 ± 52.44. HRCTV D90, HRCTV D95, and sigmoid D2cc were not statistically different among the four groups (p > 0.05). However, the target fitness in group one, especially at the cervix, was poor. The rectum D2cc was 351.49 ± 32.90, 361.49 ± 28.09, 370.82 ± 24.44, and 375.33 ± 30.90. The rectum D2cc in group one was the lower than that in group three and group four ( p < 0.05 ). The bladder D2cc was 423.59 ± 31.39, 380.75 ± 37.25, 383.27 ± 32.55, and 385.22 ± 25.79. The bladder D2cc in group one was higher than the other groups ( p < 0.05 ). The maximum rectum limit dose (400cGy) is lower than the bladder (500cGy), and HRCTV is a whole in the IPSA algorithm; these result in the insufficiency or even absence of cervix dose that first need to meet in clinics. In conclusion, IPSA condition optimization can improve the quality of treatment plan in 3D brachytherapy and make it closer to clinical practice.

show abstract

“…Studies have shown that with a help of diagnostic MRI without the applicators in situ , HR-CTV can be contoured consistently by CT, and consensus guidelines for CT delineation of HR-CTV at the time of brachytherapy have been published ( 9 , 11 ). Additionally, meta-analyses have disclosed the superiority of 3D-IGBT compared with two-dimensional brachytherapy planning with point A in local control and morbidities ( 12 , 13 ).…”

Section: Image-guided Brachytherapy Of the Cervical Cancermentioning

confidence: 99%

Combined Interstitial and Intracavitary High-Dose Rate Brachytherapy of Cervical Cancer

et al. 2022

View full text Add to dashboard Cite

High-dose-rate brachytherapy by remote afterloading is now performed under three-dimensional image guidance by CT or MRI. Three-dimensional image-guided brachytherapy in cervical cancer disclosed that the traditional intracavitary brachytherapy by Manchester method cannot deliver an adequate dose to the large tumor with resulting local recurrence. To improve the local control rate, combined interstitial and intracavitary (hybrid) brachytherapy can increase the dose to the large parametrial involvement without increasing the dose to the rectum and bladder. Whether hybrid brachytherapy can be performed safely on a multi-institutional basis remains to be studied. From 2015, phase I/II study of hybrid brachytherapy was launched in Japan, and it was revealed that hybrid brachytherapy can be performed safely and with a high quality of radiation dose distribution in a multi-institutional study. In Japan, the number of patients undergoing hybrid brachytherapy in cervical cancer is rapidly rising. Education and clinical trial are very important to establish hybrid brachytherapy in the management of cervical cancer.

show abstract

Effects of 3D image-guided brachytherapy compared to 2D conventional brachytherapy on clinical outcomes in patients with cervical cancer: A systematic review and meta-analyses

Cited by 18 publications

References 46 publications

Point-A vs. volume-based brachytherapy for the treatment of cervix cancer: A meta-analysis

Point-A vs. volume-based brachytherapy for the treatment of cervix cancer: A meta-analysis

Optimizing the IPSA Conditions to Improve the Treatment Plan Quality in Brachytherapy for Cervical Cancer

Combined Interstitial and Intracavitary High-Dose Rate Brachytherapy of Cervical Cancer

Contact Info

Product

Resources

About