Effects of 1α-hydroxycholecalciferol on growth performance, parameters of tibia and plasma, meat quality, and type IIb sodium phosphate cotransporter gene expression of one- to twenty-one-day-old broilers

Abstract

This experiment was conducted to investigate the effects of 1alpha-hydroxycholecalciferol (1alpha-OH D3) on the growth performance, tibia and plasma parameters, nutrient utilization, meat quality of the breast and thigh, and type IIb sodium phosphate cotranspoter gene expression of broilers. A total of 96 males of 1-d-old Arbor Acres broilers were randomly assigned to 8 cages of 12 birds each. Two dietary treatments were applied to 4 cages each. Diet 1 was prepared as the basal diet (nonphytate phosphorus, 0.21%), whereas diet 2 was the basal diet supplemented with 5 microg/kg of 1alpha-OH D3. Results showed that supplementation of the basal diet with 1alpha-OH D3 increased growth performance, tibia ash and strength, plasma inorganic phosphate concentration, utilization of total phosphorus and nonphytate phosphorus, lightness and yellowness of the breast and thigh meat, and intestinal type IIb sodium phosphate cotranspoter mRNA expression, whereas it decreased the shear force and water-holding capacity of the thigh meat. These data suggest that the addition of 1alpha-OH D3 might improve growth performance, tibia development, and meat quality in 1- to 21-d-old broilers by increasing the absorption and retention of phosphorus.

Effect of different vitamin D3 metabolites on intestinal calcium homeostasis-related gene expression in broiler chickens

“…Similarly, our results also confirm the previous reports that no significant effects were observed on growth performance of broiler chickens at 21 days of age after supplementation of the diet with 1α(OH)D 3 , 25(OH)D 3 , or 1,25(OH) 2 D 3 . Furthermore, 1α(OH)D 3 did not alter bone breaking strength, tibia calcium, and phosphorus content in broiler chickens at 21 days of age (Han et al, 2009). Consistently, we also found that vitamin D 3 metabolites did not improve bone breaking strength and bone mineral deposition after feeding for three weeks.…”

“…Dietary supplementation of 1,25(OH) 2 D 3 significantly regulates the expression of NaPi-IIb cotransporter in the intestine of rats (Katai et al, 1999). In broilers, 1α(OH)D 3 also has a similar effect on regulation of intestinal NaPi-IIb cotransporter gene expression (Han et al, 2009). Here, we also demonstrated that vitamin D 3 metabolites could rapidly induce the levels of NaPi-IIb cotransporter mRNA in the intestine of broiler chickens.…”

“…The animal protocol was approved by local Institutional Animal Care and Use Committee . The concentration of vitamin D metabolites described earlier (Yarger et al, 1995;Roberson and Edwards, 1996;Chou et al, 2009;Han et al, 2009) was used in the present study. For examination of growth performance, mineral levels, and breaking strength, fortyeight one-day-old broilers (Avian) were randomly allocated to four different treatment groups (n = 12 per group) that were fed: basal diet (control), basal diet plus 5 μg/kg of 1α(OH)D 3 , basal diet plus 69 μg/kg of 25(OH)D 3 , and basal diet plus 5 μg/kg of 1,25(OH) 2 D 3 .…”

Use of 25-hydroxycholecalciferol in Diets of Broiler Chickens: Effects on Growth Performance, Immunity and Bone Calcification

“…Since, the efficiency of conversion for cholecalciferol to active metabolites and 1α, 25-(OH) 2 -D 3 ] in the biological systems is not 100%, serum 25-OH-D 3 is considered the best available biomarker of exposure to dietary sources of VIT-D3. Theses observation have stimulated the research towards the study of using VIT-D3 metabolites in poultry feed in other to improve bird productivity, bone calcification and egg sell quality (Garcia et al, 2001;Keshavarz, 2003;Driver et al, 2006;Shim et al, 2008;Chou et al, 2009;Han et al, 2009;Valkonen at al., 2010). Nowadays, animal welfare is a big concern in the livestock industry of developed countries.…”

The effects of dietary cholecalciferol and 1α-hydroxycholecalciferol levels in a calcium- and phosphorus-deficient diet on growth performance and tibia quality of growing broilers

“…Dietary vitamin D 3 (Rao et al, 2006), 1,25-(OH) 2 D 3 (Edwards, 2002), and 1α-OH D 3 Han et al, 2009) increased the serum Ca and Pi concentrations in broilers. In contrast, Driver et al (2008) reported that 1α-OH D 3 did not affect the serum Pi content in non-obese diabetic mice.…”