Effects of 17β-estradiol on colorectal cancer development after azoxymethane/dextran sulfate sodium treatment of ovariectomized mice

Song, Chin Hee; Kim, Nayoung; Lee, Sun Min; Nam, Ryoung Hee; Choi, Soo In; Kang, So Ra; Shin, Eun Hee; Lee, Dong Hoon; Lee, Ha Na; Surh, Young Joon

doi:10.1016/j.bcp.2019.04.011

Cited by 41 publications

(34 citation statements)

References 44 publications

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“…These changes are characterized by increased infiltration of pro-inflammatory macrophages and by epithelia permeability in the colon 8 . Estrogen treatment has been shown to elicit an anti-inflammatory response in the colon of mouse models for colitis 32,48 . Our transcriptomic data reveal that both sexes' immune response were altered upon HFD feeding, but with clear sex differences.…”

Section: Discussionmentioning

confidence: 99%

High-fat diet and estrogen impacts the colon and its transcriptome in a sex-dependent manner

Hases

Archer

Indukuri

et al. 2020

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There is a strong association between obesity and colorectal cancer (CRC), especially in men, whereas estrogen protects against both the metabolic syndrome and CRC. Colon is the first organ to respond to high-fat diet (HFD), and estrogen receptor beta (ERβ) can attenuate CRC development. How estrogen impacts the colon under HFD and related sex differences has, however, not been investigated. To dissect this, mice were fed control diet or HFD for 13 weeks and administered receptor-selective estrogenic ligands for the last three weeks. We recorded impact on metabolism, colon crypt proliferation, macrophage infiltration, and the colon transcriptome. We found clear sex differences in the colon transcriptome and in the impact by HFD and estrogens, including on clock genes. ERα-selective activation reduced body weight and generated systemic effects, whereas ERβ-selective activation had local effects in the colon, attenuating HFD-induced macrophage infiltration and epithelial cell proliferation. We here demonstrate how HFD and estrogens modulate the colon microenvironment in a sex- and ER-specific manner.

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Section: Discussionmentioning

confidence: 99%

High-fat diet and estrogen impacts the colon and its transcriptome in a sex-dependent manner

Hases

Archer

Indukuri

et al. 2020

Sci Rep

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“…AOM was used as a cancer initiator since it induces O 6 -methylguanine adducts into DNA during replication, leading to G → A transitions [88]. The AOM applied together with an agent that produces inflammation in the colon (DSS) favored the development of neoplastic lesions due to the damage caused in the colon's epithelial barrier; besides, an overexpression of oxidative biomarkers has been observed in the PC of AOM/DSS for 8-12 weeks [89][90][91]. The results showed that the AOM/DSS group had a higher concentration of products derived from protein oxidation (CO) and nitrites that indicated oxidative damage, which peaked on Week 7.…”

Section: Discussionmentioning

confidence: 99%

Modification of In Vitro and In Vivo Antioxidant Activity by Consumption of Cooked Chickpea in a Colon Cancer Model

et al. 2020

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Chickpea has been classified as a nutraceutical food due to its phytochemical compounds, showing antioxidant, anti-inflammatory, and anticancer activity. To investigate this, we evaluated the effect of cooking on the nutritional and non-nutritional composition and the in vitro and in vivo antioxidant activity of chickpea seed. The latter was determined by the variation in the concentration of nitric oxide (NO), oxidized carbonyl groups (CO), malondialdehyde (MDA), and the expression of 4-hydroxy-2-nonenal (4-HNE) in the colon of male BALB/c mice fed with a standard diet with 10 and 20% cooked chickpea (CC). We induced colon cancer in mice by administering azoxymethane/dextran sulfate sodium (AOM/DSS); for the evaluation, these were sacrificed 1, 7, and 14 weeks after the induction. Results show that cooking does not significantly modify (p < 0.05) nutritional compounds; however, it decreases the concentration of non-nutritional ones and, consequently, in vitro antioxidant activity. The in vivo evaluation showed that animals administered with AOM/DSS presented higher concentrations of NO, CO, MDA, and 4-HNE than those in animals without AOM/DSS administration. However, in the three evaluated times, these markers were significantly reduced (p < 0.05) with CC consumption. The best effect on the oxidation markers was with the 20% CC diet, demonstrating the antioxidant potential of CC.

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“…UC is connected with the Keap1/Nrf2 signaling pathway, and influences Nrf2, Keap1, and Nrf2-related target genes and their expression (Lu et al, 2016). Glutamate-cysteine ligase catalytic subunit (GCLC), glutamate-cysteine ligase modifier subunit (GCLM), h em e o x y ge n a s e-1 ( H O -1 ) a n d NA D ( P ) H q u in on e dehydrogenase 1 (NQO1) belong to the Nrf2 downstream antioxidant enzymes, which are associated with treatment of UC (Song et al, 2019). Therefore, activation of Keap1/Nrf2 signaling pathway could be a promising therapeutic approach for UC.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Bruguiera gymnorrhiza (L.) Lam. Fruit on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice: Role of Keap1/Nrf2 Pathway and Gut Microbiota

et al. 2020

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homeostasis. BGF possessed protective effect against DSS-induced colitis. The potential mechanism of BGF may involve the amelioration of inflammatory and oxidative status, activation of Keap1/Nrf2 signaling pathway, and maintenance of micro-ecological balance of the host. This study provides experimental evidence for the traditional application of BGF in the treatment of diarrhea, and indicates that BGF may be a promising candidate against colitis.

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Effects of 17β-estradiol on colorectal cancer development after azoxymethane/dextran sulfate sodium treatment of ovariectomized mice

Cited by 41 publications

References 44 publications

High-fat diet and estrogen impacts the colon and its transcriptome in a sex-dependent manner

High-fat diet and estrogen impacts the colon and its transcriptome in a sex-dependent manner

Modification of In Vitro and In Vivo Antioxidant Activity by Consumption of Cooked Chickpea in a Colon Cancer Model

Protective Effect of Bruguiera gymnorrhiza (L.) Lam. Fruit on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice: Role of Keap1/Nrf2 Pathway and Gut Microbiota

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