Effects of 13-Cis Retinoic Acid Therapy on Human Antibody Responses to Defined Protein Antigens

Sidell, Neil; Connor, Michael; Chang, Bieshia; Lowe, Nicholas J.; Borok, Michael

doi:10.1111/1523-1747.ep12505593

Cited by 29 publications

(11 citation statements)

References 23 publications

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“…A larger observational study conducted in 1055 Ecuadorian children also found no association (57). The effect of VAS on antibody response to diphtheria and/or tetanus toxoids has been investigated in 8 clinical trials (91,95,(97)(98)(99)(100)(101)(102). Doses and schedules of VA supplements, target population, and study designs (randomization, use of placebo, etc.)…”

Section: Inactivated Vaccinesmentioning

confidence: 99%

“…An additional clinical trial (randomization not specified) conducted in young American adults found that administration of VA over a 4-mo period did not have any effect on any characteristic of tetanus antitoxin response (antibody increase, time to peak, or antibody levels postimmunization) compared with the control group (no placebo) (101). A RCT investigating the association between VA and diphtheria antitoxin response has been conducted in HIV-infected drug users but will not be detailed in this paper (98).…”

Section: Inactivated Vaccinesmentioning

confidence: 99%

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Landscape Analysis of Interactions between Nutrition and Vaccine Responses in Children

Savy

Edmond²,

Fine³

et al. 2009

The Journal of Nutrition

131

146

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The world's poorest children are likely to be malnourished when receiving their childhood vaccines. It is uncertain whether this affects vaccine efficacy and whether the coadministration of nutrient supplements with vaccines has beneficial or detrimental effects. More recently, a detrimental interaction between vitamin A (VA) supplementation (VAS) and the killed diphtheria-tetanus-pertussis vaccine given in early childhood has been suggested. This report provides a critical review of the published interactions between nutritional status and/or supplementation and vaccine responses in children. Due to an absence of evidence for most nutrients, this analysis focused on protein-energy, vitamins A and D, and iron and zinc. All vaccines were considered. Both observational studies and clinical trials that led to peer-reviewed publications in English or French were included. These criteria led to a pool of 58 studies for protein-energy malnutrition, 43 for VA, 4 for vitamin D, 10 for iron, and 22 for zinc. Our analysis indicates that malnutrition has surprisingly little or no effect on vaccine responses. Evidence for definitive adjunctive effects of micronutrient supplementation at the time of vaccination is also weak. Overall, the paucity, poor quality, and heterogeneity of data make it difficult to draw firm conclusions. The use of simple endpoints that may not correlate strongly with disease protection adds uncertainty. A detailed examination of the immunological mechanisms involved in potential interactions, employing modern methodologies, is therefore required. This would also help us understand the proposed, but still unproven, negative interactions between VAS and vaccine safety, a resolution of which is urgently required.

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Section: Inactivated Vaccinesmentioning

confidence: 99%

Section: Inactivated Vaccinesmentioning

confidence: 99%

Landscape Analysis of Interactions between Nutrition and Vaccine Responses in Children

Savy

Edmond²,

Fine³

et al. 2009

The Journal of Nutrition

131

146

View full text Add to dashboard Cite

show abstract

“…When sera from 13 HIV negative individuals were examined, SAg,l~~-binding IgM and IgG titers varied 10-fold and lOO-fold, respectively. However, for a given individual, levels of both SAg,lzo-binding isotypes were stable over time [40,25]. Since SAg,lzo-binding Ig levels are a stable polymorphic trait in the population, we tested the prediction that SAg,lzo-binding Ig titers correlate with resistance or susceptibility to viral transmission.…”

Section: Epidemiology Of Sagop120 -Binding Igmentioning

confidence: 99%

HIV-1gp120: A Novel Viral B Cell Superantigen

Townsley-Fuchs

Neshat

Margolin

et al. 1997

International Reviews of Immunology

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The envelope glycoprotein of the human immunodeficiency virus (HIV-1), gp120, has recently been characterized as a novel immunoglobulin superantigen (Ig-SAg) [1,2]. Analogous to the interaction of SAgs with T cells, gp120 binds to an unusually large proportion of immunoglobulins (lgs) from HIV-uninfected individuals; most, if not all of these Igs are members of the VH3 family [3]. Functionally, gp120 preferentially stimulates VH3 B cells in vitro. This stimulation correlates with an in vivo VH3 activation during HIV infection. Curiously, this initial activation is followed by a subsequent depletion of VH3-expressing B cells as individuals progress to AIDS. In this article we will review our current understanding of the superantigenic properties of HIV gp120. Specifically we will focus on structural aspects of the binding interaction. on the ontological development of these superantigen-binding antibodies, and on potential roles that this unconventional Ig-pathogen interaction might play in the pathogenesis of HIV-induced disease.

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“…Determination of retinoid concentrations. Samples of spent media were extracted and assayed for ATRA and 9-cis-RA based on techniques previously described from this laboratory for analysis of serum [28]. Briefly, at the appropriate times over a 5-day period, the samples were added to four parts by volume of cold methanol containing butylated hydroxytoluene (0.…”

Section: Introductionmentioning

confidence: 99%

Enhanced potency of 9-cis versus all-trans-retinoic acid to induce the differentiation of human neuroblastoma cells

Han¹,

Chang²,

Connor

et al. 1995

Differentiation

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Effects of 13-Cis Retinoic Acid Therapy on Human Antibody Responses to Defined Protein Antigens

Cited by 29 publications

References 23 publications

Landscape Analysis of Interactions between Nutrition and Vaccine Responses in Children

Landscape Analysis of Interactions between Nutrition and Vaccine Responses in Children

HIV-1gp120: A Novel Viral B Cell Superantigen

Enhanced potency of 9-cis versus all-trans-retinoic acid to induce the differentiation of human neuroblastoma cells

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