Enhanced potency of 9-cis versus all-trans-retinoic acid to induce the differentiation of human neuroblastoma cells

Han, Guangyang; Chang, Bieshia; Connor, Michael; Sidell, Neil

doi:10.1046/j.1432-0436.1995.5910061.x

Cited by 35 publications

(20 citation statements)

References 30 publications

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“…Kadison et al (33) showed that exogenous atRA and 9-cis RA have completely different ontogenic effects during pancreas differentiation. However, few comparative studies between RA isomers have shown 9-cis to be almost 10 times more potent than the all-trans form (37,38). Our results also suggest that atRA has a similar type of ontogenic effects as 9-cis RA at a higher dose.…”

Section: Discussionsupporting

confidence: 55%

All-Trans Retinoic Acid Induces Differentiation of Ducts and Endocrine Cells by Mesenchymal/Epithelial Interactions in Embryonic Pancreas

et al. 2003

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Retinoids during the embryonic period act as a mesenchymal inducer in many organs, including kidney, lung, central nervous system, and gut. Retinoic acid (RA) demonstrates insulinotropic effects in adult pancreas, but only a limited study has elucidated its role in pancreatic organogenesis. In this study, we have analyzed the existence of RA-signaling machinery in embryonic pancreas and evaluated its role using

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Section: Discussionsupporting

confidence: 55%

All-Trans Retinoic Acid Induces Differentiation of Ducts and Endocrine Cells by Mesenchymal/Epithelial Interactions in Embryonic Pancreas

et al. 2003

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“…Plum and ClagettDame (1995) showed that both atRA and 9-cis-RA inhibited the proliferation of human neuroblastoma cells and induced RAR␤ mRNA expression with equal capabilities. Other studies show however, that 9-cis-RA is more potent in its differentiating and anti-proliferative capabilities (Han et al, 1995;Lovat et al, 1997). Opposite effects of 9-cis-RA and atRA have also been observed (Hellemans et al, 1999), but these did not involve the nervous system.…”

Section: Discussionmentioning

confidence: 97%

“…It is also not clear whether atRA and 9-cis-RA have similar physiological roles. In differentiating human neuroblastoma cells, both 9-cis-RA and atRA produced a dose-dependent increase in neurite outgrowth and inhibition of proliferation (Han et al, 1995). 9-cis-RA, like atRA, is also a potent inducer of digit pattern duplications in the chick wing bud (Thaller et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Detection of Endogenous Retinoids in the Molluscan CNS and Characterization of the Trophic and Tropic Actions of 9-cisRetinoic Acid on Isolated Neurons

Dmetrichuk

Carlone²,

Jones³

et al. 2008

J. Neurosci.

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Retinoic acid (RA) is an active metabolite of Vitamin A that plays an important role in the growth and differentiation of many cell types. All-trans RA (atRA) is the retinoic acid isomer that has been most widely studied in the nervous system, and can induce and direct neurite outgrowth from both vertebrate and invertebrate preparations. The presence and role of the 9-cis-RA isomer in the nervous system is far less well defined. Here, we used high-pressure liquid chromatography (HPLC) and mass spectrometry (MS) to show for the first time, the presence of both atRA and 9-cis-RA in the CNS of an invertebrate. We then demonstrated that 9-cis-RA was capable of exerting the same neurotrophic and chemotropic effects on cultured neurons as atRA. In this study, significantly more cells showed neurite outgrowth in 9-cis-RA versus the EtOH vehicle control, and 9-cis-RA significantly increased the number and length of neurites from identified neurons after 4 d in culture. 9-cis-RA also extended the duration of time that cells remained electrically excitable in culture. Furthermore, we showed for the first time in any species, that exogenous application of 9-cis-RA induced positive growth cone turning of cultured neurons. This study provides the first evidence for the presence of both atRA and 9-cis-RA in an invertebrate CNS and also provides the first direct evidence for a potential physiological role for 9-cis-RA in neuronal regeneration and axon pathfinding.

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“…Neuronal cell lines can be induced to differentiate by adding different drugs or growth factors to the media, or the removal of serum from the media. Differentiation results in a non-dividing cell with many of the Tumilowicz et al (1970), Gotti et al (1987), Clementi et al (1986), Reynolds and Perez-Polo (1981) LA-N-5 Human neuroblastoma Cholinergic Retinoic acid Haussler et al (1983), Robson and Sidell (1985), Han et al (1995) …”

Section: Cell Linesmentioning

confidence: 99%

Developmental neurotoxicity testing in vitro: Models for assessing chemical effects on neurite outgrowth

2008

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Enhanced potency of 9-cis versus all-trans-retinoic acid to induce the differentiation of human neuroblastoma cells

Cited by 35 publications

References 30 publications

All-Trans Retinoic Acid Induces Differentiation of Ducts and Endocrine Cells by Mesenchymal/Epithelial Interactions in Embryonic Pancreas

All-Trans Retinoic Acid Induces Differentiation of Ducts and Endocrine Cells by Mesenchymal/Epithelial Interactions in Embryonic Pancreas

Detection of Endogenous Retinoids in the Molluscan CNS and Characterization of the Trophic and Tropic Actions of 9-cisRetinoic Acid on Isolated Neurons

Developmental neurotoxicity testing in vitro: Models for assessing chemical effects on neurite outgrowth

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