Effects of 12 Weeks of Essential Amino Acids (EAA)-Based Multi-Ingredient Nutritional Supplementation on Muscle Mass, Muscle Strength, Muscle Power and Fatigue in Healthy Elderly Subjects: A Randomized Controlled Double-Blind Study

Negro, Massimo; Perna, Simone; Spadaccini, Daniele; Castelli, Luca; Barbero, Marco; Cescon, Corrado; Rondanelli, Mariangela; D’Antona, Giuseppe

doi:10.1007/s12603-019-1163-4

Cited by 27 publications

(43 citation statements)

References 67 publications

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“…Apparently, we can putatively suggest, that the physical exercise intensities reached in the sessions, as well as the BCAAs supplementation effect compared to the daily protein intake in this population, were not sufficient to induce a significant impact on the inflammatory status in the participants in this study. Other interventions with older persons have been able to show a strong anti-inflammatory effect of exercise training, but it seems that these results were observed for intervention periods longer than 16 weeks [43,44]. Interestingly, even though an increase in the levels of the pro-inflammatory cytokine TNF-α was observed in the ME + BCAAs group from T1 to T2 and T3, this finding was accompanied by a proportional increase of the anti-inflammatory cytokine IL-10, since the TNF-α/IL-10 ratio was not different in this group over time.…”

Section: Discussionmentioning

confidence: 99%

“…The BCCAs were diluted in 200 mL of water and given immediately after the exercise sessions to the participants in the ME + BCAAs and BCAAs groups [43]. The supplement dose was fixed at 0.21 g total BCAAs/kg/session, with individual portion sachets, administered in the morning, between 09:00 and 11:30 a.m. [44]. We opted to exclude maltodextrin or the carnosine-based placebo here, since the carbohydrate ingestion could mask the effort perception and cognitive indexes in our older persons volunteers, compared to the amino acid supplementation [45].…”

Section: Full Characterization Of the Mip 371 Oral Bcaasmentioning

confidence: 99%

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Effect of Training-Detraining Phases of Multicomponent Exercises and BCAA Supplementation on Inflammatory Markers and Albumin Levels in Frail Older Persons

Caldo-Silva

Furtado

Chupel³

et al. 2021

Nutrients

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Nowadays, it is accepted that the regular practice of exercise and branched-chain amino acids supplementation (BCAAs) can benefit the immune responses in older persons, prevent the occurrence of physical frailty (PF), cognitive decline, and aging-related comorbidities. However, the impact of their combination (as non-pharmacological interventions) in albumin and the inflammatory markers is not fully understood. Therefore, we investigated the effect of a 40-week multifactorial intervention [MIP, multicomponent exercise (ME) associated or not with BCAAs] on plasma levels of inflammatory markers and albumin in frail older persons (≥75 years old) living at residential care homes (RCH). This study consisted of a prospective, naturalistic, controlled clinical trial with four arms of multifactorial and experimental (interventions-wahshout-interventions) design. The intervention groups were ME + BCAAs (n = 8), ME (n = 7), BCAAs (n = 7), and control group (n = 13). Lower limb muscle-strength, cognitive profile, and PF tests were concomitantly evaluated with plasma levels of albumin, anti- and pro-inflammatory cytokines [Interleukin-10 (IL-10) and Tumor Necrosis Factor-alpha (TNF-α) respectively], TNF-α/IL-10 ratio, and myeloperoxidase (MPO) activity at four different time-points: Baseline (T1), after 16 weeks of multifactorial intervention (T2), then after a subsequent 8 weeks washout period (T3) and finally, after an additional 16 weeks of multifactorial intervention (T4). Improvement of cognitive profile and muscle strength-related albumin levels, as well as reduction in the TNF-α levels were found particularly in ME plus BCAAs group. No significant variations were observed over time for TNF-α/IL-10 ratio or MPO activity. Overall, the study showed that MIP triggered slight alterations in the inflammatory and physical function of the frail older participants, which could provide independence and higher quality of life for this population.

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Section: Discussionmentioning

confidence: 99%

Section: Full Characterization Of the Mip 371 Oral Bcaasmentioning

confidence: 99%

Effect of Training-Detraining Phases of Multicomponent Exercises and BCAA Supplementation on Inflammatory Markers and Albumin Levels in Frail Older Persons

Caldo-Silva

Furtado

Chupel³

et al. 2021

Nutrients

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“…Nevertheless, evidence has emerged to demonstrate that a MIS compromising of WP (30 g), creatine (2.5 g), vitamin D (500 IU), calcium (400 mg) and n-3 FAs (1500 mg) may have a beneficial effect on skeletal muscle mass and strength [208,211], inflammation [212] and cognition [213] in older adults, although no effect on exercise-induced myogenesis was observed [214]. MIS, however, did not benefit the adaptive remodelling response to a 12-week multi-modal, concurrent RET and high-intensity interval training intervention in older men [215].…”

Section: Multi-ingredient Supplementsmentioning

confidence: 99%

Nutritional Strategies to Offset Disuse-Induced Skeletal Muscle Atrophy and Anabolic Resistance in Older Adults: From Whole-Foods to Isolated Ingredients

et al. 2020

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Preserving skeletal muscle mass and functional capacity is essential for healthy ageing. Transient periods of disuse and/or inactivity in combination with sub-optimal dietary intake have been shown to accelerate the age-related loss of muscle mass and strength, predisposing to disability and metabolic disease. Mechanisms underlying disuse and/or inactivity-related muscle deterioration in the older adults, whilst multifaceted, ultimately manifest in an imbalance between rates of muscle protein synthesis and breakdown, resulting in net muscle loss. To date, the most potent intervention to mitigate disuse-induced muscle deterioration is mechanical loading in the form of resistance exercise. However, the feasibility of older individuals performing resistance exercise during disuse and inactivity has been questioned, particularly as illness and injury may affect adherence and safety, as well as accessibility to appropriate equipment and physical therapists. Therefore, optimising nutritional intake during disuse events, through the introduction of protein-rich whole-foods, isolated proteins and nutrient compounds with purported pro-anabolic and anti-catabolic properties could offset impairments in muscle protein turnover and, ultimately, the degree of muscle atrophy and recovery upon re-ambulation. The current review therefore aims to provide an overview of nutritional countermeasures to disuse atrophy and anabolic resistance in older individuals.

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“…Recent research has explored the potential role of interventions such as long chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) (Logan and Spriet 2015;Smith et al 2015), whey protein (Zhu et al 2015), vitamin D (Dhesi et al 2004), and resveratrol (Alway et al 2017) in addition to multi-ingredient supplements alone (Negro et al 2019) or combined with exercise training interventions (Verreijen et al 2015;Rondanelli et al 2016;Bell et al 2017). These studies generally aim to either augment the training-induced improvements, or curb the decline in the absence of exercise, in LBM and muscle function in older adults, each with varying degrees of success.…”

Section: Introductionmentioning

confidence: 99%

Effects of a Long Chain n-3 Polyunsaturated Fatty Acid-rich Multi-ingredient Nutrition Supplement on Body Composition and Physical Function in Older Adults with Low Skeletal Muscle Mass

Palumbo

McSwiney

Hone

et al. 2021

Journal of Dietary Supplements

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Six months of supplementation with a multi-ingredient nutrition supplement was investigated in older adults with low skeletal muscle mass given the recently purported benefits of such approaches. Community-dwelling older adults (age, 74.9 ± 3.6 y; M/F, 18/19) participated in a double-blind, placebo-controlled, randomized trial involving daily consumption of either fruit juice placebo (PLA) or supplement (SUPP) in the form of a 200-mL carton of a juice-based emulsion of long chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) (3000 mg as 1500 mg docosahexaenoic acid and 1500 mg eicosapentaenoic acid), whey protein isolate (8 g), vitamin D3 (400 IU), and resveratrol (150 mg). Body composition, physical function, and circulating markers of metabolic health were assessed at baseline (PRE), and after 3 (MID) and 6 (POST) months of supplementation. Lean body mass (LBM) was unchanged in either group, but fat mass increased in SUPP by 1.41 (0.75, 2.07) kg at POST (þ6.4%; p < .001; d ¼ 0.20). Hand-grip strength was maintained in SUPP, but declined in PLA by 2.50 (0.81, 4.19) kg at POST (À6.8%; p ¼ .002; d ¼ 0.38). Short physical performance battery score was unchanged in PLA, but increased in SUPP by 1.13 (0.41, 1.84) above PRE at POST (p ¼ .001; d ¼ 0.47). Circulating markers of metabolic health were unchanged in response to the intervention in either PLA or SUPP. Long-term supplementation with an LC n-3 PUFA-rich multi-ingredient nutrition supplement demonstrates potential efficacy for improving physical function in older adults in the absence of exercise training and independent of a change in LBM.

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Effects of 12 Weeks of Essential Amino Acids (EAA)-Based Multi-Ingredient Nutritional Supplementation on Muscle Mass, Muscle Strength, Muscle Power and Fatigue in Healthy Elderly Subjects: A Randomized Controlled Double-Blind Study

Cited by 27 publications

References 67 publications

Effect of Training-Detraining Phases of Multicomponent Exercises and BCAA Supplementation on Inflammatory Markers and Albumin Levels in Frail Older Persons

Effect of Training-Detraining Phases of Multicomponent Exercises and BCAA Supplementation on Inflammatory Markers and Albumin Levels in Frail Older Persons

Nutritional Strategies to Offset Disuse-Induced Skeletal Muscle Atrophy and Anabolic Resistance in Older Adults: From Whole-Foods to Isolated Ingredients

Effects of a Long Chain n-3 Polyunsaturated Fatty Acid-rich Multi-ingredient Nutrition Supplement on Body Composition and Physical Function in Older Adults with Low Skeletal Muscle Mass

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