Effects of 12-week aerobic exercise on patient-reported outcomes in women with systemic lupus erythematosus

Gavilán‐Carrera, Blanca; Vargas‐Hitos, José Antonio; Morillas-de-Laguno, Pablo; Rosales-Castillo, Antonio; Sola-Rodríguez, Sergio; Callejas‐Rubio, José Luis; Sabio, José Mario; Soriano‐Maldonado, Alberto

doi:10.1080/09638288.2020.1808904

Cited by 18 publications

(22 citation statements)

References 51 publications

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“…Our results clearly showed that the relationship between physical activity, pulmonary function, and QoL was signi cantly mediated by CRF in patients with lung cancer resection. This result was similar to the previous works that CRF mediated the effects of 12-week aerobic exercise on general fatigue in a woman with systemic lupus erythematosus [17]. As a mediator, CRF also affected the effects of a Mediterranean diet on the mental component summary of QoL.…”

Section: Discussionsupporting

confidence: 91%

The association of pulmonary function, physical activity, cardiorespiratory fitness, Borg dyspnea scales and health related quality of life in patients with resected lung cancer

Chen

Liu

et al. 2021

Preprint

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Background Understanding the determinants of quality of life for the patients after lung resection would be beneficial to affect the prevention programs and the treatment strategies. This novel study aims to explore the relationship between pulmonary function, physical activity, cardiorespiratory fitness (CRF), dyspnea, and the health-related quality of life (HRQoL) of patients with resected lung cancer. Methods A cross-sectional study design with 38 lung cancer survivors after surgery for one month was conducted. We assessed CRF by measuring maximal oxygen consumption (VO2max) and anaerobic threshold (VT).Forced vital capacity (FVC) was measured using a spirometer. Physical activity, dyspnea, and HRQoLwereinvestigated by 6-minute walking distance (6MWD), Borg dyspnea scales, and the SF-36 Health Survey (SF-36), respectively.Data analyses were conducted using SmartPLS to examine path analyses between the measures. Results There was a significant relationship between CRF andHRQoL in this cohort of cancer survivors.FVC (f2 = 0.265) and 6MWD (f2 = 0.389) have a medium to large effect size on the perceived CRF while CRF (f2 = 0.467) was found to have large effect sizes on perceived QoL. More importantly, our results showed that CRF positively and significantly mediated the paths betweenFVC, 6MWD, andHRQoL[β = 0.22 (0.457*0.474),P < 0.01; β = 0.28 (0.525*0.540), P < 0.01; respectively]. Conclusions Pulmonary function, physical activity, and dyspnea had an indirect effect on the quality of life in patients with resected lung cancer. Furthermore, CRF mediates pulmonary function and physical activity to produces an impact on their quality of life.

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Section: Discussionsupporting

confidence: 91%

The association of pulmonary function, physical activity, cardiorespiratory fitness, Borg dyspnea scales and health related quality of life in patients with resected lung cancer

Chen

Liu

et al. 2021

Preprint

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“…It is important to note that fatigue improvements have been described in SLE independently of changes in fitness levels and that fatigue is a multifaceted phenomenon that might be affected by different peripheral and central mechanisms [ 50 ]. However, we have observed reductions in general fatigue after our exercise intervention with cardiorespiratory fitness as a mediator [ 20 ], which could be related to a better conditioning in these patients.…”

Section: Discussionmentioning

confidence: 99%

“…Exercise is a potential intervention that significantly increases cardiorespiratory fitness [ 18 , 19 ], improves cardiovascular function and PROs (i.e., fatigue, depression, etc.) [ 20 ] in patients with SLE. Although exercise has shown to decrease cardiovascular morbidity and mortality in the general population [ 21 , 22 ], its benefits in SLE population are understudied to the extent that exercise hardly appear in the EULAR guidelines for the management of this chronic disease [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Heart Rate Variability in Women with Systemic Lupus Erythematosus: Association with Health-Related Parameters and Effects of Aerobic Exercise

Martínez-Rosales

Sola-Rodríguez

Vargas‐Hitos

et al. 2020

IJERPH

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Abnormal heart rate variability (HRV) has been observed in patients with systemic lupus erythematosus (SLE). In a combined cross-sectional and interventional study approach, we investigated the association of HRV with inflammation and oxidative stress markers, patient-reported outcomes, and the effect of 12 weeks of aerobic exercise in HRV. Fifty-five women with SLE (mean age 43.5 ± 14.0 years) were assigned to either aerobic exercise (n = 26) or usual care (n = 29) in a non-randomized trial. HRV was assessed using a heart rate monitor during 10 min, inflammatory and oxidative stress markers were obtained, psychological stress (Perceived Stress Scale), sleep quality (Pittsburg Sleep Quality Index), fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory), and quality of life (36-item Short-Form Health Survey) were also assessed. Low frequency to high frequency power (LFHF) ratio was associated with physical fatigue (p = 0.019). Sample entropy was inversely associated with high-sensitivity C-reactive protein (p = 0.014) and myeloperoxidase (p = 0.007). There were no significant between-group differences in the changes in HRV derived parameters after the exercise intervention. High-sensitivity C-reactive protein and myeloperoxidase were negatively related to sample entropy and physical fatigue was positively related to LFHF ratio. However, an exercise intervention of 12 weeks of aerobic training did not produce any changes in HRV derived parameters in women with SLE in comparison to a control group.

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“…In the randomized controlled trial by Tench et al, only the physical function, role physical, and vitality domains were reported [ 23 ]. Moreover, one study reported only the results of the two global domains of physical and mental components of the SF-36 [ 31 ]. Furthermore, only one study used a disease-specific health-related quality of life measure, the LupusQoL [ 32 ], instead of the generic SF-36.…”

Section: Resultsmentioning

confidence: 99%

“…The intervention period in these studies ranged between six weeks and one year. Of the nine included studies, five were randomized controlled trials and were included in the meta-analysis [23][24][25][26][27], two studies did not use random allocation in their group assignment [29,31], one study was a pilot study without the use of a usual care control group [28], and one study compared aerobic with isotonic exercise without the use of random group assignment [30].…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Effects of Exercise Intervention on Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis of Controlled Trials

Koo

2021

Healthcare

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Exercise and physical activity have been deemed as potentially beneficial for patients with systemic lupus erythematosus (SLE). This study aimed to evaluate the effects of exercise interventions on health-related quality of life in patients with SLE using a systematic review and meta-analysis. Randomized and non-randomized controlled trials published up to July 2021 were examined using the PubMed and Embase databases. Of the 1158 articles retrieved, nine were included for systematic review. Five of them were randomized controlled trials and these were assessed using meta-analysis. Hedges’ g effect size was 0.47; 95% (confidence interval 0.21–0.73; p < 0.001) for the physical health and function aspect of health-related quality of life. None of the other seven domains of the SF-36 showed a significant effect size. However, the latter finding was limited by the small number of available trials. In conclusion, this systematic review and meta-analysis supported that exercise intervention compared to usual care might be able to improve the physical functioning domain of health-related quality of life in patients with SLE. Future high-quality randomized controlled trials that incorporate disease-specific health-related quality of life measures are needed to elucidate the role of exercise on health-related quality of life in patients with SLE.

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Effects of 12-week aerobic exercise on patient-reported outcomes in women with systemic lupus erythematosus

Cited by 18 publications

References 51 publications

The association of pulmonary function, physical activity, cardiorespiratory fitness, Borg dyspnea scales and health related quality of life in patients with resected lung cancer

The association of pulmonary function, physical activity, cardiorespiratory fitness, Borg dyspnea scales and health related quality of life in patients with resected lung cancer

Heart Rate Variability in Women with Systemic Lupus Erythematosus: Association with Health-Related Parameters and Effects of Aerobic Exercise

Effects of Exercise Intervention on Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis of Controlled Trials

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