Effects of 1-Hz repetitive transcranial magnetic stimulation on acute pain induced by capsaicin

Tamura, Yoshihiro; Okabe, Shingo; Ohnishi, Takashi; Saito, Daisuke N.; Arai, Noritoshi; Mochio, Soichiro; Inoue, Kiyoharu; Ugawa, Yoshikazu

doi:10.1016/j.pain.2003.10.011

Cited by 116 publications

(94 citation statements)

References 51 publications

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“…Tamura et al (33) demonstrated that 1 Hz rTMS to the left motor cortical area has beneficial effects on acute pain induced by capsaicin. On the other hand, there was no evidence about long-term follow-up in that study.…”

Section: Discussionmentioning

confidence: 99%

Is the Transcranial Magnetic Stimulation an Adjunctive Treatment in Fibromyalgia Patients?

Yağcı¹,

Ağırman²,

Öztürk³

et al. 2014

Turk J Phys Med Rehab

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ÖzetAmaç: Medikal tedaviye dirençli fibromiyalji hastalarında motor korteks alana uygulanan düşük frekanslı tekrarlayıcı transkraniyal manyetik stimülasyonun (tTMS) etkinliğini araştırmak. Gereç ve Yöntemler: Toplam 25 hasta randomize olarak aktif ve plasebo gruplarına ayrılarak çalışmaya alındı. Aktif tTMS grubu için stimülasyon sol primer motor korteks üzerinden motor eşik değerin %90'ı hesaplanarak 1 Hz ve 20 dakika uygulandı. Her seansta 1200 uyarı olmak üzere, iki hafta boyunca toplam 10 seans tedavi uygulandı. Plasebo grup için, parabolik koil 90° açı ile motor kortekse yerleştirildi ve aynı şekilde toplam 10 seans stimülasyon uygulandı. Sonuçlar, ağrı için vizüel analog skalası (VAS), Fibromiyalji Etkinlik Anketi (FIQ) ve Beck Depresyon Skalası (BDS) ile değerlendirildi. Bulgular: Her iki grupta da tedavi sonunda, 1 ve 3. ay sonunda ağrı derecesinde, FIQ ve BDS'de anlamlı iyileşme gözlendi. Ancak, aktif tTMS grubunda iyileşme plasebo gruba göre daha iyiydi. Tedavi sonu FIQ skorlarında aktif grupta, plasebo gruba göre istatistiksel olarak anlamlı iyileşme gözlendi. Diğer değerlendirmelerde gruplar arasında istatistiksel farklılık saptanmadı. Sonuç: Primer motor korteks üzerine düşük doz tTMS uygulamasının uzun süreli takiplerde fibromiyalji hastalarında plaseboya göre anlamlı iyileşme göstermediği görülmüştür. Anahtar Kelimeler: Fibromiyalji, transkraniyal manyetik stimülasyon, ağrı AbstractObjective: To investigate the effectiveness of low-frequency (LF) repetitive transcranial magnetic stimulation (rTMS) to the motor cortex area in fibromyalgia patients who are resistant to medical treatment. Material and Methods: A total of 25 patients were randomly assigned to the study, who were in the active rTMS (n=13) or sham stimulation (n=12) group. For the rTMS group, the main stimulation parameters were 90% of motor threshold for 60 seconds at 1 Hz and a 45-second interval between each train. Ten sessions of low-frequency rTMS, which had a total of 1200 pulses at each session, were applied to the left primary motor cortex area daily over a period of 2 weeks. For the sham group, the same parabolic coil was placed at 90° angles to the motor cortex area, and the patients received 10 sessions of sham stimulation. The outcome parameters were pain intensity, which was measured by visual analog scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), and the Beck Depression Inventory (BDI). Results: A significant improvement in pain intensity, FIQ, and BDI scores was seen at the 10 th day and first and third months in both groups. Although the mean of parameters of the rTMS groups was better than the sham group, the difference did not reach statistical significance, except FIQ scores at the 10 th day in the real rTMS group. Conclusion: Patients with fibromyalgia who enroll in real TMS did not present significant differences in long-term follow-ups with respect to those who enrolled in the sham TMS group.

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Section: Discussionmentioning

confidence: 99%

Is the Transcranial Magnetic Stimulation an Adjunctive Treatment in Fibromyalgia Patients?

Yağcı¹,

Ağırman²,

Öztürk³

et al. 2014

Turk J Phys Med Rehab

View full text Add to dashboard Cite

show abstract

“…Davidson's (1993) approach/withdrawal model of emotion specifically looks at hemispheric activation in the frontal lobes in relation to the behavioral response associated with positive and negative emotion. In neuroimaging studies of pain, bilateral activation (Lorenz, Cross, Minoshima, Morrow, Paulson, et al, 2002;Lorenz et al, 2003) and deactivation (Hsieh et al, 1996;Tamura, Okabeb, Ohnishic, Saitod, Araib, et al, 2004) of frontal cortex has been found. Investigations that have reported frontal activation with pain attribute the activation to the affective-motivational components of pain (Hsieh et al, 1996;Fulbright, Troche, Skudlarski, Gore, & Wexler, 2001).…”

Section: Motivational Models and Painmentioning

confidence: 99%

Emotion and Pain: A Functional Cerebral Systems Integration

Mollet

Harrison

2006

Neuropsychol Rev

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Emotion and pain are psychological constructs that have received extensive attention in neuropsychological research. However, neuropsychological models of emotional processing have made more progress in describing how brain regions interact to process emotion. Theories of emotional processing can describe inter-hemispheric and intra-hemispheric interactions during emotional processing. Due to similarities between emotion and pain, it is thought that emotional models can be applied to pain. The following review examines the neuropsychology of emotion and pain using a functional cerebral systems approach. Specific comparisons are made between pain and anger. Attention is given to differences in cerebral function and physiology that may contribute to the processing of emotion and pain. Suggestions for future research in emotion and pain are given.

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“…Since these areas are thought to be involved in the emotional aspect of pain processing, second pain perception might be more related to the emotional aspect than first pain perception. Tamura et al [21,22] reported that repetitive transcranial magnetic stimulation over the primary motor cortex increased the LEP amplitude and subjective pain rating scores following A fiber stimulation but decreased them following C fiber stimulation. This difference could be attributed to a difference in the activity of the insular and cingulate cortices between the two conditions.…”

Section: Discussionmentioning

confidence: 99%

Tobacco Smoking Can Potentiate C-fiber Evoked Potentials in Human Brain

Miyazaki¹,

Wang²,

Inui³

et al. 2009

TOPAINJ

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Abstract:The effects of smoking and nicotine on ultralate laser evoked potentials (LEPs), the EEG responses to C-fiber stimulation by a laser beam, were investigated in humans. Ultralate LEPs were repeatedly measured in two sessions, one after smoking, and the other in abstinence from smoking. The dominant frequency of the background EEG alpha activity, heart rate and venous plasma nicotine concentration were also measured. The peak-to-peak amplitude of the two major components (N2 and P2) of ultralate LEPs was significantly correlated both with the plasma nicotine concentration and with the background alpha frequency. The results suggest an arousal effect of nicotine on C-fiber mediated pain. The effect of nicotine on C-fiber LEPs was in the opposite direction of that on A fiber LEPs. The difference between C and A fibers might indicate a difference in effects of nicotine on first and second pain responses.

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Effects of 1-Hz repetitive transcranial magnetic stimulation on acute pain induced by capsaicin

Cited by 116 publications

References 51 publications

Is the Transcranial Magnetic Stimulation an Adjunctive Treatment in Fibromyalgia Patients?

Is the Transcranial Magnetic Stimulation an Adjunctive Treatment in Fibromyalgia Patients?

Emotion and Pain: A Functional Cerebral Systems Integration

Tobacco Smoking Can Potentiate C-fiber Evoked Potentials in Human Brain

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