Effects of 1-bromopropane, 2-bromopropane, and 1,2-dichloropropane on the estrous cycle and ovulation in F344 rats

Sekiguchi, Soichiro; Suda, Megumi; Zhai, Yali; Honma, Takeshi

doi:10.1016/s0378-4274(01)00429-5

Cited by 28 publications

(19 citation statements)

References 19 publications

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“…available to detect altered reproductive functions. In our previous papers, changes in the estrous cycle and ovulation have been shown to indicate disorders in the reproductive functions of female rats [20][21][22] . More extensive or detailed examination may result in finding some effects of perinatal exposure to BPA.…”

mentioning

confidence: 99%

Effects of in Utero and Lactational Exposure to Bisphenol A on Somatic Growth and Anogenital Distance in F1 Rat Offspring.

Kobayashi¹,

Miyagawa²,

Wang³

et al. 2002

INDUSTRIAL HEALTH

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Bisphenol A (BPA), a xenoestrogen, has been reported to mimic the actions of estrogen or to affect the endocrine glands in vivo and in vitro. In this study, we examined whether in utero and lactational exposure to BPA altered the somatic growth and anogenital distance (AGD) of F 1 offspring (1, 3, and 9 weeks of age) in vivo in rats. Dams were orally administered with various doses of BPA (0, 4, or 40 mg/kg body weight (BW)/day) from gestation day (GD) 6 through postnatal day (PND) 20. There were no significant changes in body weight, liver weight, kidneys weight, testes weight, AGD, the ratio of AGD to BW, or the ratio of AGD to the cube root of BW in BPA exposed pups compared to the vehicle-exposed control. This suggests that prenatal and postnatal exposure (indirect exposure) to BPA (4-40 mg/kg/day, GD 6-PND 20) does not affect on somatic growth or AGD of F 1 generation of male and female rats.

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confidence: 99%

Effects of in Utero and Lactational Exposure to Bisphenol A on Somatic Growth and Anogenital Distance in F1 Rat Offspring.

Kobayashi¹,

Miyagawa²,

Wang³

et al. 2002

INDUSTRIAL HEALTH

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“…The collected ova were denuded with hyaluronidase (Sigma Chemical Co., USA) and were counted under a microscope. The maximum number of ova shed into oviducts was 11 among spontaneously ovulated F344 rats in our previous studies (data not shown) 1,2) . Therefore, ovulation was considered as superovulation induced by eCG when the number of ovulated ova exceeded 11 in the present study.…”

mentioning

confidence: 67%

“…In addition, a rather long observation period is required to detect disorder of the estrous cycle in individual females even if the disorder is obvious. We showed that the number of spontaneously ovulated ova decreases in accordance with disorder of the estrous cycle as detected by observation of vaginal smears in female F344 rats injected with 2-bromopropane 1) or exposed to 1,2-dichloropropane for almost 3 weeks 2) . Also, we reported that 2-bromopropane caused the decrease of the number of ovulated ova in superovulation induced in mice by treatment with pregnant mare's serum gonadotropin (PMSG) and human chorionic gonadotropin (hCG) 3) .…”

mentioning

confidence: 69%

“…To collect ova shed into oviducts, all rats were sacrificed at 72 h (28 days of age) after the eCG or saline injection as described in previous reports 4-6, 7, 9) , and their ovaries and uteri were removed and weighed. The collection and counting of ova shed into oviducts were performed according to the methods described in our previous reports [1][2][3] . Briefly, ovulated ova were flushed by physiological saline from a 2.5 ml syringe attached to a needle of gauge size 27G × 3/4.…”

mentioning

confidence: 99%

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Experimental Model to Study Reproductive Toxicity of Chemicals using Induced Ovulation in Immature F344 Rats.

Sekiguchi¹,

Ito²,

Honma³

2003

INDUSTRIAL HEALTH

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We investigated a simple method using induced ovulation in immature rats to detect ovarian injury due to chemicals. We investigated the influence of di-(2-ethylhexyl) phthalate (DEHP) on ovulation induced by equine chorionic gonadotropin (eCG) in immature F344 rats. Single injections of 15 and 30 iu eCG induced ovulation in 4 of 6 rats and in all of 4 rats, respectively. The mean number of ovulated ova was 12.7 in the 15 iu eCG group and 8.0 in the 30 iu group. When rats received 4 daily doses of DEHP at 500 mg/kg, ovulation occurred in 4 of 6 rats in the 15 iu eCG group and in 1 of 3 rats in the 30 iu group. Mean numbers of ovulated ova were 2.50 and 0.33 ova in the 15 and 30 iu groups, respectively. Changes in ovarian and uterine weights were not found. Inhibition of ovulation by the injection of DEHP indicated the utility of induced ovulation in immature rats to detect reproductive toxicity in females.

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“…Körperge-wichtszunahme, Östruszyklus oder Gewichte von Ovar und Uterus erkennen. Bei 1000 ml/m 3 wiesen jedoch mehr Tiere einen verlängerten Östruszyklus auf, die Zahl an Eisprüngen war leicht verringert und die absoluten und relativen Ovar-und Uterusgewichte waren geringfügig niedriger (Sekiguchi et al 2002).…”

Section: Weibliche Fertilitätunclassified

1‐Brompropan [MAK Value Documentation in German language, 2011]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 50. Lieferung, Ausgabe 2011 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

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Effects of 1-bromopropane, 2-bromopropane, and 1,2-dichloropropane on the estrous cycle and ovulation in F344 rats

Cited by 28 publications

References 19 publications

Effects of in Utero and Lactational Exposure to Bisphenol A on Somatic Growth and Anogenital Distance in F1 Rat Offspring.

Effects of in Utero and Lactational Exposure to Bisphenol A on Somatic Growth and Anogenital Distance in F1 Rat Offspring.

Experimental Model to Study Reproductive Toxicity of Chemicals using Induced Ovulation in Immature F344 Rats.

1‐Brompropan [MAK Value Documentation in German language, 2011]

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