Effects of 1,3-Dimethylamylamine and Caffeine Alone or in Combination on Heart Rate and Blood Pressure in Healthy Men and Women

Bloomer, Richard J.; Harvey, Innocence; Farney, Tyler M.; Bell, Zach W.; Canale, Robert E.

doi:10.3810/psm.2011.09.1927

Cited by 39 publications

(60 citation statements)

References 25 publications

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“…HR was monitored by using a HR monitor. The Borg (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) scale of exertion was used to allow subjects to indicate their level of perceived work. Subjects were also asked to rate their overall mood/vigor by using a 0-10 point scale.…”

Section: Testingmentioning

confidence: 99%

“…Although both 1,3-D and caffeine are known to acutely elevate blood pressure, 17 caffeine has also been noted to induce vasorelaxation by stimulating the production of nitric oxide. 18 Collectively considering the above, we investigated the effect of caffeine and 1,3-D on exercise performance and blood markers of lipolysis and oxidative stress in a sample of exercise-trained men and women.…”

Section: Introductionmentioning

confidence: 98%

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Effect of Caffeine and 1,3-Dimethylamylamine on Exercise Performance and Blood Markers of Lipolysis and Oxidative Stress in Trained Men and Women

McCarthy

Farney

Harvey

2011

Journal of Caffeine Research

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Background: Caffeine is one of the most widely used ergogenic aids worldwide. Recently, caffeine has been combined with 1,3-dimethylamylamine (1,3-D) in an attempt to improve exercise performance and related variables. We investigated the effect of caffeine and 1,3-D alone and in combination on exercise performance and blood markers of lipolysis and oxidative stress. Methods: Twelve exercise-trained subjects ingested placebo, caffeine (4 mg$kg À1 ), 1,3-D (1 mg$kg À1 ), or caffeine + 1,3-D, 60 minutes before completing a 10 km run. Blood was collected before intake, immediately pre-exercise, and at 5 and 30 minutes postexercise. Samples were analyzed for glycerol, free fatty acids (FFAs), malondialdehyde, nitrate/nitrite, and trolox equivalent antioxidant capacity (TEAC). Results: Run time (minutes) was not different for placebo (52.55 -1.96), caffeine (52.00 -1.88), 1,3-D (52.02 -1.86), or caffeine + 1,3-D (52.46 -1.94) ( p > 0.05). Glycerol and FFA were higher 5 and 30 minutes postexercise compared with pretreatment and pre-exercise ( p < 0.05). A condition effect was noted for glycerol ( p = 0.01), with higher values for 1,3-D compared with caffeine + 1,3-D ( p < 0.05). A condition effect was noted for TEAC ( p = 0.0001), with higher values for placebo compared with caffeine and caffeine + 1,3-D, and higher values for 1,3-D compared with caffeine ( p < 0.05). No other effects were noted for any measured variable ( p > 0.05).

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Section: Testingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Effect of Caffeine and 1,3-Dimethylamylamine on Exercise Performance and Blood Markers of Lipolysis and Oxidative Stress in Trained Men and Women

McCarthy

Farney

Harvey

2011

Journal of Caffeine Research

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“…One study noted significant blood pressure increases following DMAA consumption. 33 There is also a case report of a young man suffering a cerebral hemorrhage after ingesting DMAA with caffeine and alcohol. 34 Anabolic Androgenic Steroids…”

Section: Adverse Effectsmentioning

confidence: 97%

Performance-Enhancing Drugs

Hatton¹,

Green²,

Ambrose

2014

Physical Medicine and Rehabilitation Clinics of North America

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“…It increases blood pressure, heart rate [5] and the frequency and strength of heart contractions [6] and possesses analeptic action of the vasomotor and respiratory center in the brain [3].…”

Section: Pharmacological Activity Of Caffeinementioning

confidence: 99%

Investigation of Some Pharmacological Effects of Caffeine and Taurine in Food Supplements

Tsvetkova¹,

Klisurov²,

Pankova³

et al. 2015

IJNFS

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Abstract:In modern times in all age groups energy supplements containing different amounts of Caffeine and Taurine are applied. Caffeine is purine alkaloid, which stimulates central nervous system action, enhances the strength and frequency of the cardiac contractions and increases the excretion of urine. Taurine is a sulfur containing amino acid, which possesses many fundamental biological roles including: effect on synaptic transmission in the central nervous system, cardiotropic action, antioxidant and anticonvulsant activity, improvement of energy processes, stimulation of reparative processes in tissues, protection of eyes cataract, decrease of cholesterol and stimulation of immune system. The combination of Caffeine and Taurine provide benefit due to obtaining synergism of pharmacological effects in increasing of physical activity, stimulation of brain action, cognition, memory and attention. In connection with the significant enlarging of the consumption of energy drinks, especially by children and young people in recent years the requirements for regulation and control of the labeling of these products in many countries are enlarged. In many food additives Caffeine and Taurine are added in not labeled high concentrations, which can provoke and increase their side effects. High consumption of Caffeine enhances its adverse effects on body: anxiety, headache, insomnia, nervousness, respiratory disorders, tachycardia, tremor, dehydration. In children the adverse reactions of Caffeine in much lower doses than adults are occurred. In high concentrations Taurine has adverse effects on brain activity and can induce psoriasis. The result of combination of Caffeine and Taurine is associated with increased diuretic effect and loss of water and salts from the body, especially in children and young people. Because of these facts the quality and quantity control of included compounds in food supplements is important for their health safety.

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Effects of 1,3-Dimethylamylamine and Caffeine Alone or in Combination on Heart Rate and Blood Pressure in Healthy Men and Women

Cited by 39 publications

References 25 publications

Effect of Caffeine and 1,3-Dimethylamylamine on Exercise Performance and Blood Markers of Lipolysis and Oxidative Stress in Trained Men and Women

Effect of Caffeine and 1,3-Dimethylamylamine on Exercise Performance and Blood Markers of Lipolysis and Oxidative Stress in Trained Men and Women

Performance-Enhancing Drugs

Investigation of Some Pharmacological Effects of Caffeine and Taurine in Food Supplements

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