Effects and Progress of Photo-Crosslinking Hydrogels in Wound Healing Improvement

Ma, Hao; Peng, Yuan; Zhang, Shunuo; Zhang, Yixin; Min, Peiru

doi:10.3390/gels8100609

Cited by 12 publications

(10 citation statements)

References 127 publications

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“…When it comes to in situ gelation properties, it is important to mention photocrosslinked hydrogels. [77][78][79] It is well known that natural ECMs have to be turned into ECM gels by enzymatic digestion, pH neutralization, ionic equilibrium, and temperature regulation. The rate of gel formation is not very fast and cannot be improved by adjusting pH, salt ion concentration, etc.…”

Section: Chemical Modificationmentioning

confidence: 99%

The engineering and application of extracellular matrix hydrogels: a review

Zhang

2023

Biomater. Sci.

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Section: Chemical Modificationmentioning

confidence: 99%

The engineering and application of extracellular matrix hydrogels: a review

Zhang

2023

Biomater. Sci.

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“…One modern approach for generating such biomaterial dressings is photoinitiated polymerization or curing of functionalized scaffold components, which can be done either at the bench for preassembled fabrication or in situ within the wound environment 20 . While there are hundreds of studies on photocrosslinked biomaterials for potential use as wound dressings, few describe in situ generation of the dressing, and even fewer have been demonstrated in animal models of dermal wounds 21 . Here, we present an updated, landscaping narrative review of light‐activated biomaterials developed for use in wound healing that have been demonstrated to be both in situ activated or generated and which have been demonstrated with in vivo efficacy in animal models.…”

Section: Introductionmentioning

confidence: 99%

“… 20 While there are hundreds of studies on photocrosslinked biomaterials for potential use as wound dressings, few describe in situ generation of the dressing, and even fewer have been demonstrated in animal models of dermal wounds. 21 Here, we present an updated, landscaping narrative review of light‐activated biomaterials developed for use in wound healing that have been demonstrated to be both in situ activated or generated and which have been demonstrated with in vivo efficacy in animal models. Materials that have been fabricated at the bench for use in animal models were not included, nor were materials that were only validated for cytocompatibility in vitro or with exclusively ex vivo testing.…”

Section: Introductionmentioning

confidence: 99%

In situ light‐activated materials for skin wound healing and repair: A narrative review

Yaron,

Gosangi,

Pallod

et al. 2024

Bioengineering & Transla Med

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Dermal wounds are a major global health burden made worse by common comorbidities such as diabetes and infection. Appropriate wound closure relies on a highly coordinated series of cellular events, ultimately bridging tissue gaps and regenerating normal physiological structures. Wound dressings are an important component of wound care management, providing a barrier against external insults while preserving the active reparative processes underway within the wound bed. The development of wound dressings with biomaterial constituents has become an attractive design strategy due to the varied functions intrinsic in biological polymers, such as cell instructiveness, growth factor binding, antimicrobial properties, and tissue integration. Using photosensitive agents to generate crosslinked or photopolymerized dressings in situ provides an opportunity to develop dressings rapidly within the wound bed, facilitating robust adhesion to the wound bed for greater barrier protection and adaptation to irregular wound shapes. Despite the popularity of this fabrication approach, relatively few experimental wound dressings have undergone preclinical translation into animal models, limiting the overall integrity of assessing their potential as effective wound dressings. Here, we provide an up‐to‐date narrative review of reported photoinitiator‐ and wavelength‐guided design strategies for in situ light activation of biomaterial dressings that have been evaluated in preclinical wound healing models.

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“…Hydrogels developed by photo-cross-linking can result in cell toxicity, or mutagenesis to cells and display anisotropy due to inhomogeneous exposure to light. [3,4] Ionic cross-linking with Ca 2+ , on the other hand, is not suitable for long-term cultures as these bonds are unstable in the biological milieu resulting in the dissolution of the gels, as a result, additional covalent cross-linking of alginate gels are pursued. [5] Ca 2+ being an important signaling molecule could also alter the biological properties of the stem cells.…”

Section: Introductionmentioning

confidence: 99%

Fine‐tuning Dynamic Cross–linking for Enhanced 3D Bioprinting of Hyaluronic Acid Hydrogels

Tavakoli,

Krishnan,

Mokhtari

et al. 2023

Adv Funct Materials

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Abstract3D bioprinting of stem cells shows promise for medical applications, but the development of an efficient bioink remains a challenge. Recently, the emergence of dynamically cross–linked hydrogels has advanced this field to obtain self‐healing materials. However, more advanced bioinks are needed that display optimum gelling kinetics, viscoelasticity, shear‐thinning property, structural fidelity, and hold the printed structures sufficiently long enough that allow maturation of the new tissue. Here, a novel extracellular matrix‐based bioink for human mesenchymal stem cells (hMSCs) is presented. Hyaluronic acid (HA) is modified with cysteine and aldehyde functional groups, creating hydrogels with dual cross–linking of disulfide and thiazolidine products. The investigation demonstrates that this cross–linking significantly improves hydrogel stability and biological properties. The bioink exhibits fast gelation kinetics, shear‐thinning, shape‐maintaining properties, high cell survival after printing with >2‐fold increase in stemness marker (OCT3/4 and NANOG), and supports cell proliferation and migration. Disulfide cross–linking contributes to self‐healing and cell migration, while thiazolidine cross–linking reduces gelation time, enhances long‐term stability, and supports cell proliferation. Overall, the HA‐based bioink fulfills the requirements for successful 3D printing of stem cells, providing a promising solution for cell therapy and regenerative medicine.

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Effects and Progress of Photo-Crosslinking Hydrogels in Wound Healing Improvement

Cited by 12 publications

References 127 publications

The engineering and application of extracellular matrix hydrogels: a review

The engineering and application of extracellular matrix hydrogels: a review

In situ light‐activated materials for skin wound healing and repair: A narrative review

Fine‐tuning Dynamic Cross–linking for Enhanced 3D Bioprinting of Hyaluronic Acid Hydrogels

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