Effects and mechanisms of total glucosides of paeony on adjuvant arthritis in rats

Xu, Hongmei; Wei, Wei; Jia, Xiaoyi; Cao, Yan; Zhang, Lei

doi:10.1016/j.jep.2006.08.019

Cited by 82 publications

(66 citation statements)

References 36 publications

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“…Rheumatoid Arthritis (RA) is an autoimmune and progressive systemic inflammatory disease, in which the immune system attacks joint tissues and potentially other body parts due to unknown causes (Xu et al, 2007;Meera et al, 2008). Though RA affects the majority of the geriatric patients and is the major problem for those patients, it may begin at any age.…”

Section: Introductionmentioning

confidence: 99%

Transdermal Drug Delivery System of Aceclofenac for Rheumatoid Arthritis and the Effect of Permeation Enhancers: In vitro and in vivo Characterization

Wang¹,

Zhao²,

Ruan³

2015

International J. of Pharmacology

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A B S T R A C T Aceclofenac is a non steroidal anti inflammatory drug which is used to manage the chronic pain and inflammation in the patients of rheumatoid arthritis. But it is associated with short half-life (2-3 h) and gastro-intestinal side effects. To overcome these problems the transdermal delivery of aceclofenac can be investigated for prolonged relief from pain and local inflammation in arthritis. The transdermal films of aceclofenac were prepared using two different permeation enhancers (A nonionic surfactant-Span-20 and a terpene-d limonene) in two different concentrations with solvent evaporation method. The prepared transdermal films were subjected to physicochemical evaluations, ex vivo permeation and in vivo anti-inflammatory studies. The prepared matrix type transdermal films showed high drug content ranging from 94.90±1.40 to 98.20±2.60 with completely flat surface and the folding endurance in the range of 120.0±9.24 to 182.0±4.20. The scanning electron microscopy showed that the drug particles were dispersed in the matrix of the film and was found to be projected on the surface of film also. The ex vivo permeation study in the modified Franz diffusion apparatus through excised rat abdominal skin in pH 7.4 phosphate buffer showed prolonged drug permeation ranging from 61.02-93.4%. The films prepared with permeation enhancers showed greater percent drug permeated at the end of 24 h. The d-limonene showed the greater permeation enhancement effect as compared to that of Span 20. Increasing the concentration of enhancers showed the increased permeation of the drug. The transdermal films were found to be non-irritant to the skin in primary skin irritation test on Wistar rats. The transdermal films with permeation enhancers showed the greater anti inflammatory activity in carrageenan induced hind rat paw edema model. It was concluded that the transdermal films of aceclofenac have the great potential for the use in treatment of arthritis. And d-limonene can have greater effect on increasing the drug flux and eliciting the anti-inflammatory effect as compared to that of Span 20 for the transdermal delivery of aceclofenac.

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Section: Introductionmentioning

confidence: 99%

Transdermal Drug Delivery System of Aceclofenac for Rheumatoid Arthritis and the Effect of Permeation Enhancers: In vitro and in vivo Characterization

Wang¹,

Zhao²,

Ruan³

2015

International J. of Pharmacology

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“…Baicalin has been found to treat inflammation through its antioxidant properties and its ability to regulate immune responses [4]. Chishao (P. lactiflora Pall) acts to clear heat, remove blood stasis, and reduce swelling [1,2]; it is a common herb used in treating gynaecological diseases and has been found to exert antiinflammatory and analgesic effects on model rats with carrageenan-induced arthritis [5,6]. Hongteng (S. cuneata Rehd.…”

Section: Discussionmentioning

confidence: 99%

Treating Ovarian Cysts with Chinese Herbs: A Case Report

Qu¹,

Zhou

et al. 2009

Forsch Komplementmed

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We report the case of a female patient suffering from continuous lower abdominal distending pain from an ovarian cyst for 1 year. The sonography taken on February 12, 2008 showed on the right ovary in the frontal position a cystic mass of 43.0 × 22.0 × 45.0 mm, which was found with an intact, regular, and thin membrane and a uniform echo without blood flow. The acoustic density of the sac fluid was transparent. Pelvic fluid collection with a depth of 10 mm existed as a liquid dark area around the uterus. A simple formula of Chinese herbs, Penyan Kang (formula for treating pelvic inflammation), was orally administered to the patient for 90 days. On the 6th return visit on May 10, 2008, the patient said that all the symptoms reported during the first visit had disappeared. The sonography taken on May 27, 2008 showed that the ovarian cyst on the right side had disappeared and that no abnormality was present. No side-effect of the treatment was reported.

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“…TGP has been reported to have a variety of pharmacological activities including the activities of anti-arthritis [5][6][7][8], liver protection [9,10], antidepressant [11], anti-inflammatory and analgesic [12]. For example, studies demonstrated that paeoniflorin could induce the Th1 cells immune tolerance, which then shifted to Th2 and Th3 cells-mediated activities to generate the anti-inflammatory and immune-regulatory effects [5].…”

Section: Pharmacological Studiesmentioning

confidence: 99%