Effectiveness of treatments for medication-related osteonecrosis of the jaw

Adjuvant therapies in the management of medication‐related osteonecrosis of the jaws: Systematic review

“…The methodological limitations with considerable risk of bias from the sole clinical trial may have contributed to the lack of measurable effect. We agree with other studies that the efficacy of HBO therapy for MRONJ treatment is still uncertain.…”

Denosumab‐related osteonecrosis of the jaw following non‐surgical periodontal therapy: A case report

“…In the present case, the advanced dental mobility and the presence of bone sequestration led us to F I G U R E 4 Cone beam computed tomography (CBCT) images showing the extent of the osteolytic process affecting the buccal and lingual cortical plates F I G U R E 5 Surgical treatment consisting of extractions of the involved teeth, sequestrectomy and a complete surgical debridement of the necrotic bone until reaching the clinically vital margins, followed by primary closure choose a less conservative therapy in an attempt to completely remove the necrotic bone; otherwise, the risk of recurrence or progression of the disease would remain (Carlson, 2014;Carlson & Basile, 2009). In this regard, although conservative treatment can stop the progression of the disease and fight superinfection, better results have been obtained with surgical treatment; therefore, an aggressive surgical approach has been proposed as the first option in the treatment of MRONJ (El-Rabbany, Sgro, Lam, Shah, & Azarpazhooh, 2017;Hayashida et al, 2017), even in the early stages of the condition (Ristow, Otto, Troeltzsch, Hohlweg-Majert, & Pautke, 2015).…”

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

“…Surgical treatments range from conservative to aggressive, such as curettage, sequestrectomy, and alveolar resection as a final resort. El-Rabbany et al 243 conducted a systematic review examining the effectiveness of treatments for MRONJ. The authors conducted a comprehensive search of MEDLINE, Embase, the Cochrane Library, and Scopus to identify randomized controlled trials (RCTs), non-RCTs, and prospective cohort studies to evaluate comparatively the effectiveness of management strategies for the treatment of MRONJ.…”