Effectiveness of tramadol as antidepressant in the learned-helplessness model of depression

Micó, Juan Antonio; Rojas-Corrales, M.O.; Moreno-Brea, M.R.; Ortega-Álvaro, A.; Roca-Vinardell, A.; Gilbert-Rahola, J.

doi:10.1016/s0924-977x(00)80212-6

Cited by 3 publications

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“…Micó and associates (2003) exposed rats to conditions that mimicked a learned helplessness model of depression. Results showed that rats responded more positively to tramadol, as opposed to placebo and/or methadone.…”

Section: The Rats and The Mice (And The Frogs)mentioning

confidence: 99%

“…Studies have shown the opioid (Sher, 2001; Jutkiewicz, 2006) and monoamine (Elhwuegi, 2004; Micó et al, 2003) systems to be involved in the regulation of mood. Several decades of studies have documented relationships between the opioid and monoamine systems.…”

Section: Under the Bridge: Opioids And Depression Treatmentmentioning

confidence: 99%

“…Laboratory research has shown potential use of tramadol as an antidepressant in rodent models (Mico ´et al, 2003;Faron-Go ´recka, Kus ´mider, Inan, Siwanowicz, & Dziedzicka-Wasylewska, 2004;Jesse, Wilhelm, Bortolatto, & Nogueira, 2010;Hopwood, Owesson, Callado, McLaughlin, & Stamford, 2001). Depression is a mood disorder effecting 10% to 25% of women and 5% to 12% percent of men and is characterized by features including; dysphoria, anhedonia, apathy, fatigue, weight fluctuation, sleep disorder, psychomotor agitation or retardation, an inability to focus, and recurrent thoughts of death (American Psychiatric Association, 2000).…”

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confidence: 99%

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Examining the use of tramadol hydrochloride as an antidepressant.

Barber¹

2011

Experimental and Clinical Psychopharmacology

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Tramadol (Ultram, Ultracet) is a centrally acting synthetic opioid with analgesic efficacy comparable to codeine. Antinociception is attributed to low but effective affinity for the mu-opioid receptor (μ), as well as reuptake inhibition of the monoamines norepinephrine (NE) and serotonin (5HT). Dual action antidepressants mirtazapine (Remeron), duloxetine (Cymbalta), and most notably venlafaxine (Effexor), which tramadol is closely related to in structure, also inhibit NE and 5HT reuptake. These medications are proven effective antidepressants and this shared monoaminergic action resulted in the research of tramadol as a potential treatment for depression. The present article intends to substantiate the use of tramadol in this manner by analyzing several decades of research which is presented as an illustration of neuronal theories, as well as lab work and case studies of both the supporting ideas and potential hazards. Finally, the article promotes the benefits of acute action in comparison to modern antidepressants and the documentation of low abuse rates while maintaining an object view of the risks, most notably, the risk for addiction from agonist action on μ-receptors.

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Section: The Rats and The Mice (And The Frogs)mentioning

confidence: 99%

Section: Under the Bridge: Opioids And Depression Treatmentmentioning

confidence: 99%

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confidence: 99%

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Examining the use of tramadol hydrochloride as an antidepressant.

Barber¹

2011

Experimental and Clinical Psychopharmacology

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Concomitant use of tramadol and venlafaxine – evaluation of antidepressant-like activity and other behavioral effects in rats

Szkutnik-Fiedler

Kus

Balcerkiewicz

et al. 2012

Pharmacological Reports

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Low-Dose Tramadol as an Off-Label Antidepressant: A Data Mining Analysis from the Patients’ Perspective

Bumpus

2020

ACS Pharmacol. Transl. Sci.

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The purpose of this analysis was to assess, from the patients' perspective, the effectiveness and relative safety of tramadol as an off-label antidepressant and to determine if patients' views and experiences are consistent with the biomedical literature. Method: A data mining approach was used to analyze databases available at drugs.com. Results: Tramadol was reported to be an effective or very effective antidepressant by 94.6% of patients (123/130) who provided ratings submitted to User Reviews for Tramadol to Treat Depression (https://www.drugs.com/comments/tramadol/ for-depression.html). When compared to 34 other antidepressants in the database titled Drugs Used to treat Depression (https://www.drugs.com/condition/depression.html), for which there were ≥100 individual reviews for each drug, tramadol was rated as being the most effective (effectiveness rating = 9.1/10). Phenelzine (effectiveness rating = 8.7/10) was the only other antidepressant having ≥100 individual reviews coupled with a very high (8.0−10.0) effectiveness rating. Eleven patients reported significant symptoms of withdrawal upon cessation of tramadol, and five patients reported loss or reduction of libido as a side effect. Most (57/72, 79.2%) patients who reported a dose consumed experienced relief from depression at low therapeutic doses (25−150 mg/day). Fourteen patients reported taking this antidepressant for 5−10 years, and four patients reported taking tramadol for 10 or more years. Results demonstrated that most patients' comments and beliefs are consistent with the biomedical literature. Conclusions: Patients' reviews coupled with a survey of the biomedical literature indicate that at low therapeutic doses in the absence of interactions with other drugs, adult patients found tramadol to be a generally safe, effective, and fast-acting medication for relief from depression.

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Effectiveness of tramadol as antidepressant in the learned-helplessness model of depression

Cited by 3 publications

References 1 publication

Examining the use of tramadol hydrochloride as an antidepressant.

Examining the use of tramadol hydrochloride as an antidepressant.

Concomitant use of tramadol and venlafaxine – evaluation of antidepressant-like activity and other behavioral effects in rats

Low-Dose Tramadol as an Off-Label Antidepressant: A Data Mining Analysis from the Patients’ Perspective

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