Effectiveness of Traditional Chinese Health-Promoting Exercise as an Adjunct Therapy for Drug Use Disorders: A Systematic Review and Meta-Analysis

Jia, Dongming; Zhou, J; Xu, Yuming

doi:10.1089/jicm.2021.0285

Cited by 7 publications

(9 citation statements)

References 39 publications

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“…To ensure that everyone is able to exercise, the patient's fitness, pain level, and access to exercise need to be measured first, as unsafe neighbourhoods, high rates of gym membership or limited space or money for exercise will reduce exercise adherence and efficacy. We recommend moderate intensity traditional Chinese health-promoting exercises, such as Baduanjin, Tai Chi, and Wuqinxi (Jia et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Social Support and Relapse Tendency Among Those Who Struggle With Drug Addiction: Multiple Mediators of Exercise Self-Efficacy and Health-Related Quality of Life

Jia

Zhang

2023

Journal of Drug Issues

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Based on social support theory and exercise promotion health theory, we verified the mediating role of exercise self-efficacy and health-related quality of life in the relationship between social support and the relapse tendency of Chinese people who struggle with drug addiction. Samples who had received traditional Chinese health-promoting exercise interventions over 3 months were recruited from two drug rehabilitation centres in Zhejiang Province ( n = 415). The participants completed the Social Support Rating Scale, Exercise Self-Efficacy Scale, Health Survey Short Form Questionnaire Chinese version, and Relapse Tendency Scale. Correlation analysis showed significant positive correlations between social support, exercise self-efficacy, and quality of life. In contrast, social support, exercise self-efficacy, and quality of life were negatively correlated with relapse tendency. In addition, intermediary effect analysis showed that social support has a direct negative predictive effect on relapse tendency in two ways: as an independent intermediary of exercise self-efficacy and as a chain intermediary of exercise self-efficacy and quality of life. Good exercise habits and adherence, as well as early establishment of social support, are beneficial not only for reducing craving and relapse behaviour but also for enhancing the quality of life of people who struggle with drug addiction, thereby facilitating the recovery efficacy for maintenance.

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Section: Discussionmentioning

confidence: 99%

The Relationship Between Social Support and Relapse Tendency Among Those Who Struggle With Drug Addiction: Multiple Mediators of Exercise Self-Efficacy and Health-Related Quality of Life

Jia

Zhang

2023

Journal of Drug Issues

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“…During the process of article retrieval, we identified one recent meta-analysis ( Jia et al, 2022 ) that had a similar purpose to the present study. However, there were two limitations to this previous study.…”

Section: Discussionmentioning

confidence: 99%

“…Exercise intensity, duration and frequency are all important in determining the outcomes (exercise induced improvement in withdrawal symptoms), with exercise intensity being the most important one. The latest meta-analysis indicated that exercise is beneficial in improving the physical and mental health of drug addicts ( Jia et al, 2022 ); however, the authors do not discuss the differences in outcome caused by different exercise intensities, which is not conducive to the formulation of precise exercise prescriptions for people with SUD. Preliminary evidence supports the view that moderate-intensity exercise may create more positive effects ( Wang et al, 2016 ), but this result needs to be verified by support from RCTs with larger samples or high evidence-level meta-analyses.…”

Section: Introductionmentioning

confidence: 99%

Effects of exercise of different intensities on withdrawal symptoms among people with substance use disorder: a systematic review and meta-analysis

Cai

et al. 2023

Front. Physiol.

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Background: Exercise can effectively attenuate withdrawal symptoms and reduce relapse, but it is unknown whether exercise of different intensities produces different results. This study aimed to systematically review the effects of different exercise intensities on withdrawal symptoms among people with substance use disorder (SUD).Methods: Systematic searches for randomized controlled trials (RCTs) on exercise, SUD, and abstinence symptoms were conducted via electronic databases, including PubMed, up to June 2022. Study quality was evaluated using the Cochrane Risk of Bias tool (RoB 2.0) for assessment of risk of bias in randomized trials. The meta-analysis was performed by calculating the standard mean difference (SMD) in outcomes of interventions involving light-, moderate-, and high-intensity exercise for each individual study using Review Manager version 5.3 (RevMan 5.3).Results: In total, 22 RCTs (n = 1,537) were included. Overall, exercise interventions had significant effects on withdrawal symptoms, but the effect size varied with exercise intensity and by outcome measure (i.e., for different negative emotions). Light-, moderate-, and high-intensity exercise reduced cravings after the intervention [SMD = −0.71, 95% CI = (−0.90, −0.52)], and there were no statistical differences between the subgroups (p > 0.05). Light-, moderate-, and high-intensity exercise reduced depression after the intervention [light, SMD = −0.33, 95% CI = (−0.57, −0.09); moderate, SMD = −0.64, 95% CI = (−0.85, −0.42); high, SMD = −0.25, 95% CI = (−0.44, −0.05)], with moderate-intensity exercise producing the best effect (p < 0.05). Only light- and moderate-intensity exercise relieved anxiety after the intervention [light, SMD = −0.48, 95% CI = (−0.71, −0.26); moderate, SMD = −0.58, 95% CI = (−0.85, −0.31)]. Only high-intensity exercise worked in alleviating stress [SMD = −1.13, 95% CI = (−2.22, −0.04)]. Both irritability and restlessness could be improved by light- and moderate-intensity exercise [irritability, SMD = −0.74, 95% CI = (−0.98, −0.50); restless, SMD = −0.72, 95% CI = (−0.98, −0.47)], and there were no statistical differences between the subgroups (p > 0.05). Moderate- and high-intensity exercise decreased withdrawal syndrome after the intervention [moderate, SMD = −0.30, 95% CI = (−0.55, −0.05); high, SMD = −1.33, 95% CI = (−1.90, −0.76)], with high-intensity exercise producing the best effects (p < 0.01).Conclusion: Overall, exercise leads to improvements in withdrawal symptoms in individuals with SUD, but these effects vary significantly between the exercise of different intensities and according to the type of withdrawal symptoms. Moderate-intensity exercise has the greatest benefits in improving depression and anxiety; high-intensity exercise has the greatest benefits in improving withdrawal syndrome.Systematic Review Registration:www.crd.york.ac.uk/PROSPERO/, identifier, CRD42022343791

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“…Studies suggest that exercise induces direct immune factor function, stimulates the mobilization and redistribution of NK cells and T cells [8,9], and reduces breast tumor growth [10,11], with an impact on mitochondrial and macronutrient metabolism [12]. Therefore, exercise has increasingly become accepted as an adjunct therapy for cancer, which suggests that it can increase the therapeutic effect of breast cancer and reduce the occurrence of adverse reactions [13]. However, the speci c mechanism is still unclear in the scienti c community.…”

Section: Introductionmentioning

confidence: 99%

Exercise training promotes the immune cytotoxicity to enhance the inhibition of Doxorubicin in a Breast Cancer Model

Qin

Gui

et al. 2023

Preprint

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Background: Physical exercise is believed to play a vital role in the prevention and treatment of cancer and its complications. However, the molecular mechanisms underlying this effect remain unclear. Methods: BALB/c female mice (n=24) were randomly divided into sedentary group (SED), exercise group (Ex), Doxorubicin group (Dox, 5 mg/kg), and Doxorubicin + exercise group (Dox + Ex) after 7 days of 4T1 cell implantation. Exercise training lasted for 28 days and included rotarod experiments and resistance training. H&E staining was used to observe histopathological changes in the tumor, spleen, and heart; The proportion of NK cells and T cells in peripheral and immune organs was analyzed by flow cytometry; The infiltration of NK and CD8 T cells and the expression levels of CD31 and VEGF in tumor tissues were evaluated by immunohistochemical; The mRNA expression levels of IL-6, IL-1β, TNF-α, TNF-α R, IFN-γ, and IFN-γ R were detected by q-PCR, and the protein expression levels of Bax, Bcl2 and cleaved caspase3 were detected by Western blot. Results: The chemotherapeutic effect of Doxorubicin on breast cancer was significantly promoted by exercise training, and its mechanism might be that exercise activates the maturation of tumor killer cells in the immune system and releases tumor suppressor factors, such as TNF-α and IFN-γ, which induces the activation of Caspase3/Bax/Bcl2 signaling pathway in tumor cells. Conclusions: It is suggested that exercise training improves chemotherapy efficacy while reducing side effects, which provides experimental evidence for the establishment of new clinical treatment strategies for breast cancer.

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Effectiveness of Traditional Chinese Health-Promoting Exercise as an Adjunct Therapy for Drug Use Disorders: A Systematic Review and Meta-Analysis

Cited by 7 publications

References 39 publications

The Relationship Between Social Support and Relapse Tendency Among Those Who Struggle With Drug Addiction: Multiple Mediators of Exercise Self-Efficacy and Health-Related Quality of Life

The Relationship Between Social Support and Relapse Tendency Among Those Who Struggle With Drug Addiction: Multiple Mediators of Exercise Self-Efficacy and Health-Related Quality of Life

Effects of exercise of different intensities on withdrawal symptoms among people with substance use disorder: a systematic review and meta-analysis

Exercise training promotes the immune cytotoxicity to enhance the inhibition of Doxorubicin in a Breast Cancer Model

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