Effectiveness of topicalNigella sativafor vitiligo treatment

Abstract

Vitiligo is a pigment disease characterized by the disruption of melanocyte structure and function. Its etiology is unknown; however, genetic predisposition, biochemical factors, and neural mechanisms are thought to be effective. Although many agents are being used for its treatment, generally there is no absolute cure. The aim of the present study is to evaluate the effectiveness of topical Nigella sativa seed oil on vitiligo patients. Thirty‐three vitiligo patients were included in the study. Totally 47 areas were evaluated in all patients. Cream containing N sativa seed oil was topically applied to hands, face, and genital region two times a day for 6 months. Statistically significant repigmentation was detected in hands, face, and genital region, the three treatment areas, and the p values are found .005, .001, and .004, respectively. N sativa can be used as an adjuvant therapy that can contribute to the treatment especially in sensitive skin areas like genital region.

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

“…A clinical study with 33 vitiligo patients aimed to understand repigmentation rate in different body surfaces upon application of black cumin seed oil. The study showed that the highest repigmentation rate was achieved in hands, face, and genital region after applying black cumin seed oil-containing cream in the morning and evening [ 232 ].…”

The Therapeutic Effects of Nigella sativa on Skin Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…In all, 14 records out of 300 unique articles were possibly eligible; ultimately, 4 papers were included in this meta-analysis [ 11 , 12 , 14 , 15 ] ( Figure 1 ). Of the 14 included studies, one was conducted in Germany [ 10 ], the Czech Republic [ 11 ], Tukey [ 22 ], India [ 13 ], and Bangladesh [ 17 ], two were conducted in Iraq [ 14 , 18 ], and the other was carried out in Iran [ 12 , 15 , 16 , 19 – 21 , 23 ]. Studies were done on individuals who had experienced different types of skin disease, as listed in Table 1 .…”

A review of Nigella sativa plant‐based therapy in dermatology

“…30 A study by Sarac et al showed significant repigmentation in the hands (P < 0.005), face (P < 0.001), and genital region (P < 0.004) of 33 vitiligo patients after topical N. sativa cream was applied twice daily for 6 months. 31 Ghorbanibirgani et al also showed noticeable changes in 26 patients treated twice daily with N. sativa for 6 months, assessed by a significant decrease in the Vitiligo Area Scoring Index from 4.98 to 3.75 (P < 0.020). 32 No adverse events were reported by patients in either study.…”

“…A study by Sarac et␣al. showed significant repigmentation in the hands ( P < 0.005), face ( P < 0.001), and genital region ( P < 0.004) of 33 vitiligo patients after topical N. sativa cream was applied twice daily for 6 months 31 . Ghorbanibirgani et␣al.…”