Effectiveness of Topical NSAIDs in a Gastric Cancer Patient with Bone Metastasis Pain during Therapy with Opioids and Oral NSAIDs

Terayama, Kazutoshi; Hamana, Mayumi; Tsuchiya, Masao; Watanabe, Tamaki; Enomoto, Hiromi; Yasuno, Nobuhiro; Miura, Keita; Ohta, Kazuki; Watanabe, Shigekazu

doi:10.1248/yakushi.19-00260

Cited by 2 publications

(1 citation statement)

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“…These drugs can be used to reduce the severe pain associated with cancer patients and improve their life. In addition, they have a role in angiogenesis inhibition in inflamed lesions that can be considered as one of the histological determinations of different diseases such as rheumatoid arthritis, obesity, and cancer [50][51][52] . Metanalysis in 2017 by Shi et al showed that a significant decrease in the severity of head and neck cancers involving oral cancer among individuals taking NSAIDs and mostly seen with the use of aspirin, ibuprofen, and COX-2 inhibitor than other NSAIDs [53] .…”

Section: Non-steroidal Anti-inflammatory Drugs (Nsaids)mentioning

confidence: 99%

A novel approach in diagnosis and treatment of oral cancer

Sabea¹,

Al-Mahmood²,

Salih³

2023

Int. J. Surg. Sci.

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Oral squamous cell carcinoma (OSCC) is a group of highly malignant tumors that may arise from the surface epithelium or minor salivary glands. Approximately 85% to 95% of all oral cancer is squamous cell carcinoma (OSCC) which is a very aggressive cancer, representing one of the most common malignancies worldwide. Oral potentially malignant disorders (OPMDs) regroup a variegate set of different histological lesions, characterized by the potential capacity to transform in OSCC. The conventional treatment modalities of oral cancer include surgical excision, radiation therapy, chemotherapy, or a combination of these approaches. These traditional methods may not use effectively due to their poor bioavailability. Hence, reformulation of drugs or improved drug delivery may enhance bioavailability. Targeted therapy is a novel approach to deliver drugs to specific cells, organs, cell organelles to improve the collection of the delivered active components in the desired site of action and decrease the side effects and systematic toxicity that accompanied conventional therapy. Nanodentistry uses nanotechnological approaches with a particle size of 10-9 meters including nondiagnostic, nanoparticles, and nanodrugs for diagnosing, treatment, and prevention of oral and dental diseases to improve dental health. This review describes different nanoparticles accompanied by therapeutic agents for effective and useful diagnosis and treatment of oral cancer.

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