“…Fifteen of the included studies in the systematic review had a non-randomised design [ 36 , 37 , 39 , 41 , 42 , 51 , 54 , 58 , 60–62 , 64 , 65 , 67 , 69 ]. Supplementary Table 3 shows that many of these scored well on method quality [ 36 , 37 , 39 , 41 , 42 , 51 , 58 , 60–62 , 65 , 69 ]. Three had a medium risk of bias; one associated with the statistical analysis, differences in participants in control and experimental groups and a lack of multiple measurements [ 54 ] another due to differences in participants, lack of follow-up and statistical analysis [ 64 ] and one had differences in participants in the control and experimental groups, uncertainty regarding multiple measurements, and unclear reporting of follow up measures [ 67 ].…”