Effectiveness of the Salivary Occult Blood Test as a Screening Method for Periodontal Status

Shimazaki, Yoshihiro; Akifusa, Sumio; Takeshita, Toru; Shibata, Yukie; Doi, Yasufumi; Hata, Jun; Ninomiya, Toshiharu; Hirakawa, Yoichiro; Kiyohara, Yutaka; Yamashita, Yoshihisa

doi:10.1902/jop.2010.100304

Cited by 26 publications

(44 citation statements)

References 29 publications

(56 reference statements)

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“…In the Hisayama study, periodontal status was assessed using PD, CAL and BOP at two sites for all teeth (the mesio-buccal and mid-buccal sites), except for the third molars since these teeth when partially impacted frequently have pseudopockets, based on the third National Health and Nutrition Examination Survey (US) III method. Details of the periodontal examination have been described elsewhere23. In the Yangpyeong study, PD, CAL and BOP were measured at six sites per tooth (mesio-buccal, mid-buccal, disto-buccal, mesio-lingual, mid-lingual and disto-lingual) on the following index teeth: 12, 15, 17, 21, 24, 26, 32, 35, 37, 41, 44 and 46.…”

Section: Methodsmentioning

confidence: 99%

Distinct composition of the oral indigenous microbiota in South Korean and Japanese adults

Takeshita

Matsuo

Furuta

et al. 2014

Sci Rep

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A comparison of national surveys on oral health suggested that the population of South Korea has a better periodontal health status than that of Japan, despite their similar inherent backgrounds. Here, we investigated differences in oral bacterial assemblages between individuals from those two countries. To exclude potential effects of oral health condition on the microbiota, we selected 52 Korean and 88 Japanese orally healthy adults (aged 40–79 years) from the participants of two cohort studies, the Yangpyeong study in South Korea and the Hisayama study in Japan, and compared the salivary microbiomes. The microbiota of the Japanese individuals comprised a more diverse community, with greater proportions of 17 bacterial genera, including Veillonella, Prevotella, and Fusobacterium, compared to the microbiota of the Korean individuals. Conversely, Neisseria and Haemophilus species were present in much lower proportions in the microbiota of the Japanese individuals than the Korean individuals. Because higher proportions of Prevotella and Veillonella and lower proportions of Neisseria and Haemophilus in the salivary microbiome were implicated in periodontitis, the results of this study suggest that the greater proportion of dysbiotic oral microbiota in the Japanese individuals is associated with their higher susceptibility to periodontitis compared to the Korean individuals.

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Section: Methodsmentioning

confidence: 99%

Distinct composition of the oral indigenous microbiota in South Korean and Japanese adults

Takeshita

Matsuo

Furuta

et al. 2014

Sci Rep

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“…As context for our study, there are published reports of six studies assessing the correlation of various oral occult blood tests with various periodontal measures (10–15). Comparison of our results with those of the published studies is challenging because of the differences amongst the oral occult detection methods, periodontal measures and study populations.…”

Section: Discussionmentioning

confidence: 99%

“…In a screening survey of dental students, 13.6% of the Japanese and 43.5% of Chinese dental students tested positive by the SOBT (14). And in 2011, a community-based sample of 1,998 adults aged 40–79 years and with ≥ 20 teeth were enrolled in a study comparing Perioscreen® SOBT with periodontal status determined using the Third National Health and Nutrition Examination Survey protocol with PMPE (15,16). Healthy periodontal status was defined as <15% of teeth with BOP and 0% of teeth with probing depths ≥4mm.…”

Section: Discussionmentioning

confidence: 99%

“…Poor periodontal status was defined as ≥15% of teeth with BOP or >0% of teeth with probing depths ≥4mm. Using those case definitions, the SOBT sensitivity was 0.72 and the specificity was 0.52 (15). Though further comparisons with the historical studies are not warranted because of differences in the periodontal measures (9), together the studies’ results support further investigation of the Perioscreen® SOBT as a correlative marker of periodontal inflammation.…”

Section: Discussionmentioning

confidence: 99%

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Feasibility study of a salivary occult blood test to correlate with periodontal measures as indicators of periodontal inflammation in a population of pregnant women

Reed

Manz

Snipe

et al. 2015

Journal of Oral Science

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The purpose of this feasibility study was to investigate the correlation of a salivary occult blood test (SOBT) with traditional periodontal measures to assess the feasibility of the SOBT as a measure of periodontal inflammation in a population of women during pregnancy. Recognizing previous SOBT studies’ limitations, this study evaluated correlation of the Perioscreen® Sunstar SOBT with traditional measures from a full mouth periodontal examination. Data were collected at 3 times during pregnancy (12–14, 24–28, and 36 weeks) from women participating in an ongoing study of pregnancy and inflammation. Descriptive statistics and correlations were generated for SOBT scores with periodontal measures. Preliminary data were analyzed from 7 women with 3 visits, 7 with 2, and 9 with 1 visit’s data. For these 44 visits’ data, mean percent sites with bleeding on probing (BOP) for SOBT scores = 0, 2 and 5 was 58%±18%, 68%±14%, and 72%±19%, respectively. Correlations for percent of sites with BOP and continuous SOBT score was 0.301, p-value=0.0469 and dichotomous SOBT was 0.32, p-value=0.0339. Results for feasibility, measured as recruitment of participants, acceptance of protocols, distribution of periodontal inflammation and preliminary correlations, support SOBT as a correlated marker of periodontal inflammation in this population of pregnant women.

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“…Shimazaki et al analyzed the effectiveness of salivary occult blood test (SOBT) as a screening method for periodontal status (45). They reported that sensitivity and specificity of the SOBT in screening for poor periodontal status were 0.72 and 0.52, respectively.…”

Section: Current Salivary Diagnostic Tests For Periodontal Diseasementioning

confidence: 99%

Recent Advances in Salivary Proteomics, Genomics and Transcriptomics: A Reliable Tool in Periodontal diagnosis – A Review

Rajapriya

Saravanan

et al. 2014

ADUM

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Aim: This review intends to provide a highlight on the potential application of salivary proteomics in periodontal diagnosis and attempts to throw light on the emerging salivary diagnostic tools for periodontal disease detection. Background: Clinical parameters for detection of periodontitis such as probing depth, attachment level, bleeding on probing, plaque index, and radiographic assessment of alveolar bone loss provide information on the severity of periodontitis, but they do not measure disease activity. Ideally, development and application of rapid and simple diagnostic tests based on host salivary or immune factors may facilitate early detection of patients at risk for periodontal diseases, allow appropriate intervention, decrease the need for more aggressive treatment and improve the response to periodontal therapy. Results: Studies have shown that saliva could be used as a diagnostic fluid as it is one of the inexpensive, noninvasive and easy-to-use diagnostic methods. Salivary constituents that have been studied as potential diagnostic biomarkers for periodontal disease includes locally produced proteins of host and bacterial origin, genetic/genomic biomarkers such as DNA and mRNA of host origin, bacteria and bacterial products, ions, steroid hormones and volatile compounds. Conclusion: Periodontal oral diagnostic devices will enable screening of large populations, more quickly and effectively. Use of salivary biomarkers to sample large populations will help to identify at-risk groups more effectively and increase access to treatment for those most at need, thereby, improving public health.

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Effectiveness of the Salivary Occult Blood Test as a Screening Method for Periodontal Status

Abstract: The SOBT may offer a simple screening method for periodontal status when a thorough periodontal examination is not possible, although it is not sufficiently specific to be a reasonable substitute for a periodontal examination.

Cited by 26 publications

References 29 publications

Distinct composition of the oral indigenous microbiota in South Korean and Japanese adults

Distinct composition of the oral indigenous microbiota in South Korean and Japanese adults

Feasibility study of a salivary occult blood test to correlate with periodontal measures as indicators of periodontal inflammation in a population of pregnant women

Recent Advances in Salivary Proteomics, Genomics and Transcriptomics: A Reliable Tool in Periodontal diagnosis – A Review

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