Effectiveness of prostaglandin F2α in restoration of HMG-HCG induced ovulation in indomethacin-treated rhesus monkeys

Wallach, Edward E.; Bronson, Richard; Hamada, Yasuo; Wright, Karen H.; Stevens, Vernon C.

doi:10.1016/0090-6980(75)90099-4

Cited by 30 publications

(15 citation statements)

References 19 publications

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“…PG production PGs are important factors involved in the ovulatory process, since injection of inhibitors blocks ovulation (Wallach et al 1975, Ainsworth et al 1979, Watson & Sertich 1991, Brännström 1993. The ovarian production of PGs and its regulation has been studied by several authors.…”

Section: Production and Activation Of Proteolytic Enzymesmentioning

confidence: 99%

The interleukin-1 system and female reproduction

Gérard¹,

Caillaud²,

Martoriati³

et al. 2004

Journal of Endocrinology

148

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Interleukins (ILs) are known best for their involvement in the immune system and their role during inflammation. In the ovary, a growing body of evidence suggests that the ovarian follicle is a site of inflammatory reactions. Thus ovarian cells could represent sources and targets of ILs. Since then, the IL-1 system components (IL-1 , IL-1 , IL-1 receptor antagonist, IL-1 receptors) have been demonstrated to have several sites of synthesis in the ovary. These factors have been localized in the various ovarian cell types, such as the oocyte, granulosa and theca cells, in several mammalian species. IL-1-like bioactivity has been reported in human and porcine follicular fluid at the time of ovulation. The role of IL-1 in local processes is still poorly known, although there is evidence for involvement in the ovulation process, and in oocyte maturation. More precisely, IL-1 may be involved in several ovulationassociated events such as the synthesis of proteases, regulation of plasminogen activator activity, prostaglandin and nitric oxide production. IL-1 also regulates ovarian steroidogenesis. These different aspects of the involvement of the IL-1 system in important aspects of female reproduction are discussed.

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Section: Production and Activation Of Proteolytic Enzymesmentioning

confidence: 99%

The interleukin-1 system and female reproduction

Gérard¹,

Caillaud²,

Martoriati³

et al. 2004

Journal of Endocrinology

148

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“…Ovulation blocked by indomethacin can be restored by exogenous PGs (Tsafriri et al, 1973;Wallach et al, 1975). However, whether PGs are involved in steroidogenesis or if steroidogenesis is an obligatory step in the ovulation process are considered unlikely because indomethacin prevents ovulation without affecting luteinization of follicles and steroid production O'Grady et al, 1972).…”

Section: Introductionmentioning

confidence: 99%

Effect of human chorionic gonadotrophin and indomethacin on ovulation, steroidogenesis and prostaglandin synthesis in preovulatory follicles of PMSG-primed immature rats

Munalulu¹,

Hillier²,

Peddie³

1987

Reproduction

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Summary. Immature rats were treated with PMSG followed 56 h later by 10 i.u. hCG. Follicles were removed at intervals after hCG injection. Transient increases in progesterone, testosterone and oestradiol synthesis were first evident 1 h after hCG, but values peaked at 3\p=n-\5h and returned to control levels by 10 h. Increased synthesis of PGE-2 and PGF-2\g=a\was not evident until 3 h and peaked at more than 10 h after hCG. Ovulation began between 8 and 10 h after hCG and 83% of animals had ovulated within 12 h. Doses of90 or 1800 \ g=m\ g indomethacin given together with hCG substantially inhibited ovulation and PG synthesis, but only the higher dose inhibited the hCG-induced elevation of progesterone and testosterone synthesis; hCG-induced oestradiol synthesis was not affected by either dose of indomethacin.We conclude that the peak of PG synthesis after hCG treatment related closely to the timing of ovulation; the steroidogenic response to hCG was not blocked by doses of indomethacin sufficient to inhibit synthesis of PGE-2 and PGF-2\g=a\ by more than 80%.

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“…Administration of PGF2a to PG-synthesis inhibitor-treated animals can restore ovulation in rodents, domestic animals, and primates (Wallach et al 1975, Murdoch et al 1986, Sogn et al 1987, Janson et al 1988. However, disruption of FP receptor expression did not prevent ovulation in mice (Sugimoto et al 1997), arguing against receptormediated action of PGF2a to initiate ovulatory events in this species.…”

Section: Discussionmentioning

confidence: 99%

“…Blockade of PG production within the follicle prevented cumulus expansion, follicle rupture, and oocyte release; restoration of periovulatory events with coadministration of the PG synthesis inhibitor and PGE2 identified PGE2 as a key mediator of ovulation in mammals (Sogn et al 1987, Peters et al 2004, including primates (Duffy & Stouffer 2002). However, additional studies have demonstrated restoration of ovulation with PGF2a administration (Wallach et al 1975, Murdoch et al 1986, Sogn et al 1987, Janson et al 1988, suggesting that PGF2a may also play a role in ovulatory processes.…”

Section: Introductionmentioning

confidence: 99%

Two pathways for prostaglandin F2α synthesis by the primate periovulatory follicle

2008

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Prostaglandin E2 (PGE2) has been identified as a PG necessary for ovulation, but the ovulatory gonadotropin surge also increases PGF2a levels in primate periovulatory follicles. To better understand the role of PGF2a in ovulation, pathways utilized for PGF2a synthesis by the primate follicle were examined. Monkeys were treated with gonadotropins to stimulate multiple follicular development; follicular aspirates and whole ovaries were removed before and at specific times after administration of an ovulatory dose of hCG to span the 40 h periovulatory interval. Human granulosa cells were also obtained (typically 34-36 h after hCG) from in vitro fertilization patients. PGF2a can be synthesized from PGH2 via the aldo-keto reductase (AKR) 1C3. AKR1C3 mRNA and protein levels in monkey granulosa cells were low before hCG and peaked 24-36 h after hCG administration. Human granulosa cells converted PGD2 into 11b-PGF2a, confirming that these cells possess AKR1C3 activity. PGF2a can also be synthesized from PGE2 via the enzymes AKR1C1 and AKR1C2. Monkey granulosa cell levels of AKR1C1/AKR1C2 mRNA was low 0-12 h, peaked at 24 h, and returned to low levels by 36 h after hCG administration. Human granulosa cell conversion of [ 3 H]PGE2 into [ 3 H]PGF2a was reduced by an AKR1C2-selective inhibitor, supporting the concept that granulosa cells preferentially express AKR1C2 over AKR1C1. In summary, the ovulatory gonadotropin surge increases granulosa cell expression of AKR1C1/AKR1C2 and AKR1C3. Both of these enzyme activities are present in periovulatory granulosa cells. These data support the concept that follicular PGF2a can be synthesized via two pathways during the periovulatory interval.

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Effectiveness of prostaglandin F2α in restoration of HMG-HCG induced ovulation in indomethacin-treated rhesus monkeys

Cited by 30 publications

References 19 publications

The interleukin-1 system and female reproduction

The interleukin-1 system and female reproduction

Effect of human chorionic gonadotrophin and indomethacin on ovulation, steroidogenesis and prostaglandin synthesis in preovulatory follicles of PMSG-primed immature rats

Two pathways for prostaglandin F2α synthesis by the primate periovulatory follicle

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