The interleukin-1 system and female reproduction

Gérard, Nadine; Caillaud, Maud; Martoriati, Alain; Goudet, Ghylène; Lalmanach, Anne-Christine

doi:10.1677/joe.0.1800203

Cited by 148 publications

(104 citation statements)

References 111 publications

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“…IL10 is essential for the modulation of the immune response, and deficiencies in IL10 can lead to tissue damage (Cyktor & Turner 2011). In addition, the IL1 system is involved with both pathologic states as well as normal reproductive function (Takehara et al 1994, Van der Hoek et al 1998, Martoriati et al 2003, Gerard et al 2004). IL1RN mediates IL1, which, if overactive, can damage tissue (Gerard et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Endometrial inflammatory markers of the early immune response in mares susceptible or resistant to persistent breeding-induced endometritis

Woodward¹,

Christoffersen²,

Campos³

et al. 2013

Reproduction

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Transient endometritis after breeding is necessary for clearance of bacteria and spermatozoa; however, in a subpopulation of mares, the inflammation fails to resolve in a timely fashion. The objective of this study was to describe the uterine inflammatory response in mares susceptible or resistant to persistent breeding-induced endometritis (PBIE) during the first 24 h after induction of uterine inflammation. Twelve mares were classified as susceptible (nZ6) or resistant (nZ6) to PBIE. Mares were inseminated over five estrous cycles and endometrial biopsies were collected at one time point per cycle before (0) and 2, 6, 12, and 24 h after insemination. qPCR analysis for IL1B, IL6, IL8, IFNG, TNF (TNFA), IL10, and IL1RN was performed, and endometrial inflammatory cells were counted for each sample. Relative quantification values reported fold changes in mRNA expression from 0 h values. A general pattern of expression post insemination was observed in both groups of mares. Cytokine mRNA increased at 2 h, peaked between 2 and 12 h, and then decreased. Differences were detected between groups of mares 6 h after challenge; resistant mares had higher mRNA expression of IL6, IL1RN, and IL10 than susceptible mares. Susceptible mares had an increased number of polymorphonuclear neutrophils in the endometrium 2 and 12 h after breeding when compared with resistant mares. These findings describe an inherent difference in the initial immune response to insemination and may help explain the transient nature of inflammation in resistant mares, whereas susceptible mares develop a persistent inflammation.

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Section: Discussionmentioning

confidence: 99%

Endometrial inflammatory markers of the early immune response in mares susceptible or resistant to persistent breeding-induced endometritis

Woodward¹,

Christoffersen²,

Campos³

et al. 2013

Reproduction

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“…In line with this possibility, IL-1b is known to play a role in both ovulation and oocyte maturation. 114 For instance in the mare, intrafollicular injection of IL-1b lead to increased ovulation, but also a very low rate of embryo development possibly owing an alteration of ovocyte maturation. 115 Similarly IL-1b perfusion in the rabbit ovary revealed a block in embryo development at the four-cell stage upon IL-1b stimulation.…”

Section: Intracellular Flagellin: Detection By the Nlr Proteins Naip mentioning

confidence: 99%

Inflammatory caspases and inflammasomes: master switches of inflammation

2006

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Fifteen years have passed since the cloning and characterization of the interleukin-1b-converting enzyme (ICE/caspase-1), the first identified member of a family of proteases currently known as caspases. Caspase-1 is the prototypical member of a subclass of caspases involved in cytokine maturation termed inflammatory caspases that also include caspase-4 caspase -5, caspase -11 and caspase -12. Efforts to elucidate the molecular mechanisms involved in the activation of these proteases have uncovered an important role for the NLR family members, NALPs, NAIP and IPAF. These proteins promote the assembly of multiprotein complexes termed inflammasomes, which are required for activation of inflammatory caspases. This article will review some evolutionary aspects, biochemical evidences and genetic studies, underlining the role of inflammasomes and inflammatory caspases in innate immunity against pathogens, autoinflammatory syndromes and in the biology of reproduction. Inflammatory CaspasesThe history of caspases began with the identification of an aspartate-specific protease activity involved in the conversion of the 31 kDa proIL-1b precursor to its active 17 kDa biologically active form, 1,2 and the identification of caspase-1 as the protease responsible for proIL-1b maturation. 3,4 The subsequent discovery of ced-3, that shares similarities with caspase-1 and which is involved in programmed cell death (PCD) in Caenorhabditis elegans, suggested that caspases might play fundamental roles in apoptosis. 5 As reviewed in the papers accompanying this issue of Cell Death and Differentiation, the role of apoptotic caspases in C. elegans and in vertebrates is crucial and deal with many facets of cell biology, development and diseases. In this review, we will focus on a subset of caspases present only in vertebrates and known as inflammatory caspases.Inflammatory caspases (also known as group I caspases) are encoded by three main genes in humans caspase-1, caspase-4 and caspase-5 and three main genes in mouse, caspase-1, caspase-11 and caspase-12. 6,7 In mammals, these caspases are characterized by the presence of a CARD domain at the N-terminus (Figure 1a). Human, chimp and mouse inflammatory caspases share significant similarity and are organized in a single locus (Figure 1c). Phylogenetic analysis of the conserved CARD domain suggests that the inflammatory caspases can be separated in evolutionaryrelated clusters (Figure 1b). The caspase-1 cluster contains caspase-1 and four other genes encoding decoy caspases: cop, inca1, inca2 and iceberg. These decoy caspase-1-like genes are absent in the mouse genome, suggesting that they have arisen recently by duplication of caspase-1. Although human and mouse caspase-1 are likely orthologues, sequence analysis suggests that human caspase-4 and caspase-5 have originated from a duplication of caspase-11. 7 However, the human caspase-12 gene, which in the chimp genome contains an SHG box important for it enzymatic activity, 8 evolved towards an enzymatically inactive form at some stage...

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“…In the rat, immunoreactive IL-1a was detected in the ovary at proestrus and estrus but not at diestrus (Nappi et al 1994). Various ovarian cell types, such as the oocyte, granulosa and theca cells, have been identified as the sites of synthesis of IL-1 (Gerard et al 2004). There is evidence for the involvement of ovarian IL-1 in the ovulation process and the regulation of ovarian steroidogenesis (Gerard et al 2004).…”

Section: Regulation Of Pain By Neutrophil-derived Opioid Peptidesmentioning

confidence: 99%

“…Various ovarian cell types, such as the oocyte, granulosa and theca cells, have been identified as the sites of synthesis of IL-1 (Gerard et al 2004). There is evidence for the involvement of ovarian IL-1 in the ovulation process and the regulation of ovarian steroidogenesis (Gerard et al 2004). These considerations raise the possibility that IL-1 in these ovarian cell types may be involved in regulation of the estrous cycle.…”

Section: Regulation Of Pain By Neutrophil-derived Opioid Peptidesmentioning

confidence: 99%

The Novel Roles of Neutrophils Via Opioid Peptides: Regulation of the Estrous Cycle and Pain

Kobayashi

2013

Arch. Immunol. Ther. Exp.

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Neutrophils are excreted into the vaginal vault at metestrus during the estrous cycle, and this phenomenon has long been used to determine the phase of the estrous cycle. A much smaller number of neutrophils are also detected in the uterus and the ovary. Recently, we provided several lines of evidence supporting the notion that neutrophils infiltrate into the ovary to regulate the estrous cycle by opioid peptides. Upon inflammation, on the other hand, neutrophils infiltrate into the site of infection to suppress pain by opioid peptides. Thus, opioid peptides are key molecules by which neutrophils play a novel role in regulation of the pain and estrous cycle. In both cases, opioid peptides appear to be secreted by neutrophils stimulated with chemokines, such as MIP-2 and KC in mouse, corticotropin-releasing hormone and IL-1.

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The interleukin-1 system and female reproduction

Cited by 148 publications

References 111 publications

Endometrial inflammatory markers of the early immune response in mares susceptible or resistant to persistent breeding-induced endometritis

Endometrial inflammatory markers of the early immune response in mares susceptible or resistant to persistent breeding-induced endometritis

Inflammatory caspases and inflammasomes: master switches of inflammation

The Novel Roles of Neutrophils Via Opioid Peptides: Regulation of the Estrous Cycle and Pain

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