Effectiveness of Paroxetine for Poststroke Depression: A Meta-Analysis

Li, Lijuan; Zhifen, Han; Li, Lingxin; Han, Lin; Yan, Bo

doi:10.1016/j.jstrokecerebrovasdis.2020.104664

Cited by 8 publications

(9 citation statements)

References 14 publications

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“…Depression is characterized by high recurrence and disability rates, even leading to suicide (Jacobs, 2003), and lifetime prevalence of depression could reach 15.7% (Keller & Berndt, 2002). The preferred treatment is medication, especially selective serotonin reuptake inhibitors (Zhao et al, 2019), such as fluoxetine (Macías-Cortés et al, 2013), paroxetine (Li et al, 2020), and sertraline (Padmapriya et al, 2020), which are mainstream antidepressants. However, antidepressants are prone to drug resistance and side effects (Högberg, 2014;Howland, 2007), and long-term treatment has limited effectiveness accompanied by a high recurrence rate (Fond, 2015), which can easily lead to patient non-compliance.…”

Section: Introductionmentioning

confidence: 99%

Chinese Flower and Bird Painting: A New Form of Art Therapy for Depression

et al. 2021

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Depression is a complex psychological disorder. Although psychological counseling and traditional Western art therapy have obtained robust results in the diagnosis and treatment of depression, they are not well accepted in China due to cultural differences. Chinese flower and bird painting has been favored in China and beyond. It is of considerable significance to studying the auxiliary treatment of depression by using Chinese flower and bird painting. First of all, during observation of the painting style and works of patients with different severities of depression, such phenomena as broken strokes, roughness at the end of the painting brush, stroke discontinuity, and uneven breath are noted. These signs reflect impatience and lack of control in patients with depression. Subsequently, a three-stage Chinese flower and bird painting art therapy intervention focusing on breathing training to improve ink brush control is established, and this adjuvant art therapy was applied to 56 people with mild and moderate depression. Experimental results show that, via a 24-week Chinese flower and bird painting art therapy intervention, the observation group has a greater decline in Hamilton Rating Scale for Depression (HAMD) scores than the control group ( p < .05). The study on electroencephalogram (EEG) shows that The normal rate of brain waves of the observation group in the middle and late stages of treatment and after treatment is 73%, significantly higher than 32% in the control group. This research shows that Chinese flower and bird painting can be used as a new and effective adjuvant treatment for depression in line with Chinese characteristics and is worthy of in-depth research.

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Section: Introductionmentioning

confidence: 99%

Chinese Flower and Bird Painting: A New Form of Art Therapy for Depression

et al. 2021

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“…In all, 19 studies were excluded due to the following reasons: No necessary sample data ( n = 8), Other outcomes ( n = 5), Other reviews ( n = 4), and Other languages ( n = 2) ( Figure 1 ). Thus, 17 studies were included in the umbrella review (Yi et al, 2010 ; Eng and Reime, 2014 ; Ren et al, 2015 ; Tan et al, 2015 ; Feng et al, 2018 , 2022 ; Jin et al, 2018 ; Wang et al, 2018 , 2021 ; Liu et al, 2019 , 2021 ; Li et al, 2020 ; Cai et al, 2021 ; Lee et al, 2021 ; Zhang et al, 2021a , b ; Guo et al, 2022 ). Study characteristics and quality ratings of 17 meta-analyses/systematic reviews were summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

The efficacy of therapies for post-stroke depression in aging: An umbrella review

Xie

Geng²,

Fan³

et al. 2022

Front. Aging Neurosci.

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Post-stroke depression (PSD) is a common complication after stroke. PSD is associated with emotional disorders and psychological dependence, which are potential risk factors for stroke recurrence and suicidality. This study aimed to perform an umbrella review of therapies for PSD through a comprehensive literature search. A systematic search was conducted in the PubMed and Web of Science by two independent authors. We examined the Hamilton Depression Scale (HAMD), Activities of daily living (ADL), Neurologic function as efficacy endpoints, and the incidence of adverse events as safety profiles. Seventeen eligible studies, including 267 clinical trials were included in this study. The results showed that High-Frequency Repetitive Transcranial Magnetic Stimulation (HfrTMS), Acupuncture/EA+conventional treatment, Escitalopram, Modified Sini San, Moxibustion, Xiaoyao Formula, Paroxetine, Chinese herbal medicine, Exercise, Citalopram, and Cognitive behavioral therapy are beneficial for improving the depression symptoms of patients with PSD. HfrTMS and Sertraline may have an impact on slowing the scores of activities of daily living or neurologic function. In addition, Acupuncture/EA+conventional, Escitalopram, Citalopram, Sertraline, and Fluoxetine showed no serious adverse events in PSD patients. Our study demonstrated that 11 treatment methods can effectively improve the condition of PSD patients.

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“…The rat was placed in the center of the box. After the 5-min test, the number of squares crossed by the four paws of the rat was the horizontal score, and the number of standing hind limbs was the vertical score [ 13 ] . After the test of each rat was finished, the bottom surface of the square box was cleaned to prevent the remaining information of the animal from the previous test (such as the animal's urine and feces) from affecting the next test result.…”

Section: Methodsmentioning

confidence: 99%

“…At present, the treatment of PSD is mainly based on the tricyclic and tetracyclic drugs used in the monoamine hypothesis of depression, as well as norepinephrine and serotonin reuptake inhibitors [ 12 , 13 ]. Among them, selective serotonin reuptake inhibitors and tricyclic antidepressants are the two most widely studied drugs, and their antidepressant effects were found to be related to the improvement of synaptic plasticity [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Xingnao Jieyu Decoction Reduces Neuroinflammation through the NF-κB Pathway to Improve Poststroke Depression

Wang

Han

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The neuroinflammatory pathway regulated by nuclear factor kappa-B (NF-κB) plays an important role in the occurrence, development, and prognosis of poststroke depression (PSD). The regulatory effect of the traditional Chinese medicine compound Xingnao Jieyu decoction (XNJY) on the NF-κB pathway of PSD is still unclear. This study aimed to observe the effect of XNJY on PSD and explore the molecular mechanism of its intervention in the NF-κB pathway. Middle cerebral artery occlusion (MCAO) and chronic unpredictable mild stress were used to establish a PSD rat model. Body mass measurement, behavioral testing, Nissl staining, ELISA, and Western blot were also performed. XNJY and fluoxetine hydrochloride (Flu) treatment of PSD model rats showed significant antidepressant effects. XNJY and Flu treatment could reduce cortical and hippocampal neuronal damage. XNJY reduced inflammation and restored the levels of IL-4, IL-10, and BDNF. In addition, XNJY showed a significant regulatory effect on the NF-κB pathway and the expression of synapse-related proteins PSD-95 and SYN. These results showed that XNJY could significantly reduce the depressive symptoms of PSD rats, and this reduction may be related to the regulation of the NF-κB signaling pathway to improve neuroinflammation and synaptic function.

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Effectiveness of Paroxetine for Poststroke Depression: A Meta-Analysis

Cited by 8 publications

References 14 publications

Chinese Flower and Bird Painting: A New Form of Art Therapy for Depression

Chinese Flower and Bird Painting: A New Form of Art Therapy for Depression

The efficacy of therapies for post-stroke depression in aging: An umbrella review

Xingnao Jieyu Decoction Reduces Neuroinflammation through the NF-κB Pathway to Improve Poststroke Depression

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