The efficacy of therapies for post-stroke depression in aging: An umbrella review

Abstract

Post-stroke depression (PSD) is a common complication after stroke. PSD is associated with emotional disorders and psychological dependence, which are potential risk factors for stroke recurrence and suicidality. This study aimed to perform an umbrella review of therapies for PSD through a comprehensive literature search. A systematic search was conducted in the PubMed and Web of Science by two independent authors. We examined the Hamilton Depression Scale (HAMD), Activities of daily living (ADL), Neurologic function as efficacy endpoints, and the incidence of adverse events as safety profiles. Seventeen eligible studies, including 267 clinical trials were included in this study. The results showed that High-Frequency Repetitive Transcranial Magnetic Stimulation (HfrTMS), Acupuncture/EA+conventional treatment, Escitalopram, Modified Sini San, Moxibustion, Xiaoyao Formula, Paroxetine, Chinese herbal medicine, Exercise, Citalopram, and Cognitive behavioral therapy are beneficial for improving the depression symptoms of patients with PSD. HfrTMS and Sertraline may have an impact on slowing the scores of activities of daily living or neurologic function. In addition, Acupuncture/EA+conventional, Escitalopram, Citalopram, Sertraline, and Fluoxetine showed no serious adverse events in PSD patients. Our study demonstrated that 11 treatment methods can effectively improve the condition of PSD patients.

Non-invasive brain stimulation for the treatment of neurological and psychiatric disorders and for improving physical performance: protocol of umbrella reviews

“…51 Recently, four umbrella reviews were published regarding the effects of non-invasive neuromodulation approaches for therapeutic use. Three investigated mental disorders 44,52,53 , and one other, the improvement of cognitive outcomes in healthy and neuropsychiatric individuals. 45 Razza et al aimed to investigate the use of NIBS in the control of depression 44 and another umbrella review summarized the use of invasive and non-invasive brain stimulation techniques to treat general mental disorders.…”

“…Xie and colleagues focused of rTMS therapies for the treatment of poststroke patients. 52 However, other clinically important outcomes for post-stroke patients as motor impairment, balance and pain 53 are not comprised in the analysis.…”

Neural Mechanism and Effect of Acupuncture for Central Nervous System Diseases

“…Hence, it is important to pay attention to the mental state of electric shocks survivors. There are already some evidence-based evidence that acupuncture can alleviate post-stroke depression and cognitive impairment after stroke (Zhang et al, 2010;Xie et al, 2022). However, due to the lack of attention and records on the psychological symptoms of patients in the early stage, it is difficult for us to make a corresponding assessment of whether acupuncture can have a positive effect on the psychological state of patients at this moment.…”

“…Furthermore, a significant correlation between CNS inflammation and peripheral inflammation is also supported (Leng et al, 2018;Richards et al, 2018). It is worth noting that inflammation of the CNS is closely associated with microglia and astrocytes, and there has been a lot of evidence that inflammatory microglia and astrocytes play an important role in the development of depression (Rajkowska and Stockmeier, 2013;Peng et al, 2015;Leng et al, 2018;Xia W. et al, 2022;Xie et al, 2022).…”

Effect of Family Centered Empowerment Program on Self Efficacy, Depression and Quality of Life in Geriatric Patients with Ischemic Stroke: A Quasi-experimental Study

“…It has been considered the most common psychiatric problem of stroke, which requires more careful intervention. The risk of mortality is more in stroke survivors with depression compared with others without depression (Xie et al, 2022). One of the major concerns posed by stroke survivors is how to diagnose and optimally treat this condition, which is more common in elderly patients than younger (Lokk & Delbari, 2010).…”