Effectiveness of ozone injection therapy in temporomandibular disorders

Abstract

Temporomandibular disorder is a multifactorial disease that causes pain in the jaw and face area with nondental origin, which frequently limits talking, chewing, and other jaw activities. Various factors such as malocclusion, trauma, stress, parafunctional habits (clenching and bruxing), osteoarthritis, and synovitis play a role in its occurrence, although the etiology of these disorders is little understood. Several treatments are being used to treat these disorders. Ozone therapy has been recently introduced as one of these treatments. Considering that no extensive study has been found in this field so far, this study is aiming to report the studies that have been conducted to determine the efficacy of ozone injection therapy in temporomandibular joint disorders. This report addresses the studies which are conducted clinically, experimentally, and semi-experimentally over the past 10 years (2009–2019). The prepared articles are screened according to the inclusion criteria. In this study, total six related articles are addressed. One study was pre- and postintervention, and five studies were clinical trials. Studies show that although more studies are needed in contrast with occlusal splint, ozone therapy is generally more effective treatment for pain reduction compared to medication.

Treatment of Mandibular Hypomobility by Injections into the Temporomandibular Joints: A Systematic Review of the Substances Used

“…Ozone at the tissue level is anti-inflammatory and stimulates the immune system [71,[96][97][98]. The research conducted so far on ozone administration into TMJs cavities is insufficient to draw conclusions on this subject [97]. The Daif et al study analyzed in this systematic review cannot be compared with other therapies due to different outcome measures [71].…”

“…Ozone at the tissue level is anti-inflammatory and stimulates the immune system [71,[96][97][98]. The research conducted so far on ozone administration into TMJs cavities is insufficient to draw conclusions on this subject [97].…”

Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review

“…Several conservative treatments have been used for reducing TMD-related pain, including occlusal splint devices [ 168 , 169 ], behavioral therapies [ 170 ], manual therapy [ 171 ], laser therapy [ 172 ], transcutaneous electrical nerve stimulation (TENS) [ 173 ], dry needling [ 173 ]. In this context, O 2 O 3 therapy [ 152 , 174 , 175 , 176 ] might be considered as a promising new treatment to reduce TMD pain, although the mechanism of action should still be adequately investigated [ 177 ]. Probably, O 2 O 3 might effectively decrease inflammation with a down-regulation of pro-inflammatory cytokines and an up-regulation of IL-10 anti-inflammatory cytokine [ 123 ].…”

“…Moreover, the pressure pain threshold of the temporal muscle, masseter muscle, and TMJ lateral pole were significantly higher in the ozone group ( p = 0.035; p = 0.007; p = 0.012, respectively). The same authors also compared the bio-oxidative ozone therapy to occlusal splints therapy in patients affected by both muscle and articular TMD disorders [ 135 , 175 , 179 ], showing that both therapies were effective in the improvement of mandibular movements and VAS scores. However, evaluating the effects in terms of PPT measurement of the temporal and masseter, their results indicated that occlusal splint treatment produced better results than ozone application ( p = 0.046; p = 0.024, respectively).…”

Experience with the evidence map in oral ozone therapy - importance for integrative and complementary health practices

“…We identified 26 citations of which 10 systematic reviews (Albedah et al, 2013;Azarpazhooh & Limeback, 2008;Brazzelli et al, 2006;Deepthi & Bilichodmath, 2020;German et al, 2013;Moraschini et al, 2020;Santos et al, 2020;Sharda et al, 2021;Silva et al, 2020;Sridharan & Sivaramakrishnan, 2021) and 16 narrative reviews (Almaz & Sönmez, 2015;Chirumbolo et al, 2021;Domb, 2019;Gupta & Mansi, 2012;Haghighat & Oshaghi, 2020;Lacerda et al, 2021;Lio et al, 2020;Mohammadi et al, 2013;Nogales et al, 2008;Re et al, 2020;Seidler et al, 2008;Suh et al, 2019;Swanson et al, 2021;Tiwari et al, 2017;Trevor Burke, 2012;Tricarico et al, 2020); met the criteria for inclusion in the Map. Most of the reviews were published in the 2008, 2012 and 2014.…”