Effectiveness of methylprednisolone therapy in patients with a high-risk common type of COVID-19 pneumonia: a retrospective cohort study

Liu, Lei; Qu, Haiyan; Li, Jun Jian; Yang, Yan; Zeng, Qiu Xi; Gong, Yan; He, Zhong; Zhang, Yi He; Zhang, Wei; Liu, Bin; Li, Chun

doi:10.1007/s10238-021-00765-1

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…11 Severe COVID-19 is defined when a patient meets one of the following criteria: (1) respiratory rate ≥30x /minute; (2) blood oxygen saturation ≤ 93% at rest; (3) the partial pressure of arterial oxygen (PaO2) to the fraction of inspired oxygen (FiO2) ≤ 300 mmHg (1 mmHg = 0.133kPa); (4) and pulmonary infiltration > 50% in 48-72 hours. 16 These criteria indicated that there were 5 out of 7 patients were categorized as severe COVID-19 sufferers in this case series.…”

Section: Discussionmentioning

confidence: 91%

Liver function characteristics of COVID-19 patients with obesity at Dr. Soetomo Hospital: case series

Putra

Maimunah

2022

Bali Med J.

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Background: Coronavirus disease 2019 (COVID-19) patients with obesity are more susceptible to liver injury. There is currently no published overview regarding COVID-19 patients with liver injury in Indonesia. Our study reported 7 cases of obese COVID-19 patients with an increase of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT), followed by 5 of them developing severe symptoms of COVID-19 in isolation room of Dr. Soetomo Hospital Surabaya within June-December 2020. Case Presentation: A total of 7 COVID-19 patients, by the average age 46.2±15.5 years, were obese. The mean body mass index (BMI) was 36,3±3,4 kg/m2. Five of them experienced serious symptoms. There were 3 patients (patient no. 2, 4, 7) who had normal SGOT level, while the rest had an increased SGOT level for <2x upper limit of normal (ULN) at admission. During treatment, SGOT level increased in 5 patients for 1-<3x ULN and normal in the rest of them (patient no. 2, 4). Meanwhile, the normal SGPT levels were shown in 3 patients (patient no. 2, 4, 7) and increased in 4 others at admission for 1-<4x ULN. All of them tended to have an increased SGPT level during treatment for 1-<5x ULN. However, since the increase of SGOT and/or SGPT for >3x ULN is defined as liver injury, it happened in 2 patients that occur since admission (patient no. 3) and during treatment (patient no. 5). Conclusion: Obesity may impede the recovery of COVID-19 and manifest in the deterioration of liver function.

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Section: Discussionmentioning

confidence: 91%

Liver function characteristics of COVID-19 patients with obesity at Dr. Soetomo Hospital: case series

Putra

Maimunah

2022

Bali Med J.

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Efficacy and safety of Lianhuaqingwen capsules in high-risk common type COVID-19 pneumonia: A multicenter retrospective study

Liu,

Li,

Liu

et al. 2023

Asian Pacific Journal of Tropical Medicine

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Objective: To evaluate the clinical safety and efficacy of Lianhuaqingwen (LHQW) capsules in patients with high-risk common type COVID-19 pneumonia. Methods: A retrospective multicenter study on 383 high-risk common type COVID-19 pneumonia cases was conducted. Patients were categorized as the standard treatment (SDT) group (n=168) and the LHQW+SDT group (n=215). The primary endpoint was the rate of symptom (fever, fatigue, coughing) recovery and the secondary endpoints included the time to symptom recovery, the proportion of patients with improvement in chest CT images, the proportion of patients with clinical cure, the timing and rate of negative conversion of SARS-CoV-2 RNA assay. Results: The recovery rate was significantly higher in the LHQW+SDT group as compared with the SDT group (89.7% vs. 72.0%, P<0.01). The combined use of LHQW+SDT also showed shorter time for symptom recovery, as well as shorter time for individual symptom of fever, fatigue and coughing recovery than use of SDT alone. A higher proportion of patients in the LHQW+SDT group with improvements in chest CT images and clinical cure (77.7% vs. 57.1%, P<0.01) but the proportion of patients deteriorating to severe cases (1% vs. 25%, P<0.01) in this group was significant lower than those in the SDT group. No significant difference in negative conversion rate of viral assay results was observed (76.8% vs. 75.0%, P>0.05). No serious adverse events were reported. Conclusions: LHQW capsules could be recommended to ameliorate clinical symptoms and reduce the rate of deteriorating to severe cases for high-risk common type COVID-19 pneumonia.

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Effectiveness of methylprednisolone therapy in patients with a high-risk common type of COVID-19 pneumonia: a retrospective cohort study

Cited by 2 publications

References 31 publications

Liver function characteristics of COVID-19 patients with obesity at Dr. Soetomo Hospital: case series

Liver function characteristics of COVID-19 patients with obesity at Dr. Soetomo Hospital: case series

Efficacy and safety of Lianhuaqingwen capsules in high-risk common type COVID-19 pneumonia: A multicenter retrospective study

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