Liver function characteristics of COVID-19 patients with obesity at Dr. Soetomo Hospital: case series

Putra, Erwin Maulana Farmanda; Maimunah, Ummi

doi:10.15562/bmj.v11i3.3727

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Tannins are complex organic compounds found in plants as secondary metabolite products. 29,30 Tannins are composed of phenolic compounds which are difficult to crystallize and separate and contain protein which is difficult to precipitate. Tannins also consist of polyphenolic compounds which have antibacterial, antioxidant and astringent activities.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Analysis of Curry Leaf Extract (Murraya koenigii L.) as a Potential Animal Feed and Medicinal Ingredient

Al Arif,

Warsito,

Lamid

et al. 2024

Pharmacogn J.

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Herbal plants have been used for centuries as traditional medicine to treat various diseases. Green plants generally contain phytochemical compounds, such as vegetables and plants that add aroma to dishes, one of which is curry leaves (Murraya Koenigii). This research aims to identify the phytochemical compounds contained in curry leaves. This research was carried out from August 2023 to October 2023. The curry leaves that were obtained were converted into extract form and then the extract was tested for the content of alkaloids, flavonoids, saponins, phenolics and tannins. The research results showed that curry leaf extract contained 23.73% alkaloids, 1.24% flavonoids, 8.74% saponins, 4.4% phenolics, and 5.2% tannins. Alkaloids in plants have a role as a defense against biotic and abiotic disorders. The benefits of flavonoids in plants include anti-mutagenic, anti-inflammatory, antioxidant and anti-carcinogenic. Saponins have various benefits in the health sector, including being able to reduce cholesterol concentrations in the blood. Polyphenols have good antioxidant power because this group can provide electrons to neutralize free radical electrons formed in the body. Tannins also consist of polyphenolic compounds which have antibacterial, antioxidant and astringent activities. The results of the analysis regarding the content of secondary metabolite compounds in curry leaf extract play an important role in the development of future medicines and need to be carried out to provide knowledge to the public. This study can be a basis for bioactive content for further research to expand the use of medicinal plants in the future, especially curry plants.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Analysis of Curry Leaf Extract (Murraya koenigii L.) as a Potential Animal Feed and Medicinal Ingredient

Al Arif,

Warsito,

Lamid

et al. 2024

Pharmacogn J.

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Improvement of Liver Function (AST and ALT) and Liver Tissue Catalase levels of Wistar rats induced with Alloxan by consuming Catfish oil extract

Ngesti Rahayu,

Rietta Kumala,

Taruna

et al. 2024

RJPT

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Background: Background: Type 2 Diabetes Mellitus (T2DM) is characterized by disrupted glucose metabolism, leading to hyperglycemia and insulin resistance, often associated with Secondary Hypertension (SH). Over 80% of SH patients exhibit glucose intolerance, with nearly 30% developing T2DM. There is a strong interaction between T2DM and NAFLD, representing a complex two-way relationship that influences the prognosis of the two diseases. Catfish oil extract boasts unsaturated fatty acids, including DHA, EPA, omega-3, vitamins A, B6, B12, D, and amino acids. Objective: This study aims to assess the impact of Pangasius sp. (catfish) oil extract administration on serum AST and ALT levels, as well as liver tissue MDA and CAT levels in alloxan-induced Wistar rats (Rattus norvegicus). Materials and Methods: Employing a pure experimental approach with a post-test-only control group design, three groups of 9 white male rats (Rattus norvegicus), along with one extra male rat, were included.K1 served as the negative control group (Wistar rats not subjected to any treatment). K2 acted as the positive control group (Wistar rats subjected to alloxan-induced diabetes at 150mg/kg BW). K3 represented the treatment group (diabetic model rats treated with catfish oil extract at 73mg/kg BW). Serum AST and ALT levels, as well as MDA and CAT levels in liver tissue, were measured at the study's conclusion. Results: The highest mean MDA levels in white rat liver tissue were K2 (3034.00 + 525.25 nmol/g), and the lowest was K3(2909.33+351.01nmol/g); the mean CAT liver tissue levels in rats the highest was K1 (1063.42+133.36U/mg), and the lowest was K3(894.78+132.93U/mg), the highest mean serum ALT levels of white rats was K2(230.34+63,58 U/L), and the lowest was K1(151.54+23.12 U/L) and the highest mean serum AST level in rats was K2(448.79+618.90U/L), and the lowest was K1(61.01+14.70U/L). Conclusion: Giving catfish oil supplementation can repair the damage in liver tissue, as evidenced by reductions in MDA levels and serum ALT and AST levels in diabetic model rats within the treatment group. Alloxan induction did not affect liver tissue CAT levels, as evidenced by a consistent decrease in liver tissue CAT levels in both the positive control and treatment groups.

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Liver function characteristics of COVID-19 patients with obesity at Dr. Soetomo Hospital: case series

Cited by 2 publications

References 23 publications

Phytochemical Analysis of Curry Leaf Extract (Murraya koenigii L.) as a Potential Animal Feed and Medicinal Ingredient

Phytochemical Analysis of Curry Leaf Extract (Murraya koenigii L.) as a Potential Animal Feed and Medicinal Ingredient

Improvement of Liver Function (AST and ALT) and Liver Tissue Catalase levels of Wistar rats induced with Alloxan by consuming Catfish oil extract

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