Effectiveness of Mass Screening for Endometrial Cancer

Nakagawa-Okamura, Chikako; Sato, Shinji; Tsuji, Ichiro; Kuramoto, Hiroyuki; Tsubono, Yoshitaka; Aoki, Daisuke; Jobo, Toshiko; Oomura, Mineo; Hisamichi, Shigeru; Yajima, Akira

doi:10.1159/000326722

Cited by 51 publications

(39 citation statements)

References 7 publications

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“…At the time of cervical screening, if a participant complains of abnormal genital bleeding, postmenopausal bleeding, or abnormal menstruation, she becomes a candidate for selective screening by endometrial cytology. One report compared the prognosis of endometrial cancer detected by this screening methodology with that of endometrial cancer detected at outpatient clinics, and it showed that the 5-year survival rate was significantly higher in the screening group [22]. However, this is only one report to support the effectiveness of selective screening for endometrial carcinoma with endometrial cytology; its efficacy requires further evaluation.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Endometrial Cytology: Cytohistological Correlations in 1,441 Cancer Patients

et al. 2014

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Background: Endometrial cytology by direct intrauterine sampling is the most common test for an initial evaluation of the endometrium in Japan. However, its diagnostic value for endometrial cancer remains unknown. Here, we assess the correlation between cytopathology and histopathology to evaluate the diagnostic value of cytology for endometrial cancer. Methods: Patients with histologically confirmed endometrial cancer and controls with a normal endometrium confirmed by hysterectomy had all undergone preoperative endometrial cytology between 2001 and 2010 at our eight institutions and were retrospectively analyzed. The cytological results were compared by clinical stage, histological type, differentiation, and sampling instrument. Results: We analyzed 1,441 endometrial cancer and 1,361 control cases. Endometrial cytology detected cancer in 1,279 (916 positive and 363 suspicious) cases with a sensitivity (positive plus suspicious cases) of 88.8% and a specificity of 98.5%. The positive rate was high in advanced-stage, nonendometrioid, and undifferentiated cases, but there was no significant difference in sensitivity between these clinical conditions. Conclusion: Endometrial cytology shows a relatively high sensitivity and specificity for endometrial cancer, and neither statistical measure is significantly affected by clinical stage, histological type, differentiation, sample numbers, or sampling instrument. These findings form a superior dataset for evaluating the efficacy of endometrial cytology. © 2014 S. Karger AG, Basel

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Section: Discussionmentioning

confidence: 99%

Evaluation of Endometrial Cytology: Cytohistological Correlations in 1,441 Cancer Patients

et al. 2014

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“…It is also known that the incidence of endometrial cancer has risen each year in Japan over a period of 30 years [2]. Therefore, the early detection of endometrial cancer is important for the improvement of the long-term survival rate of patients, and endometrial cytology has been widely used in Japan as the main screening procedure [3]. Direct cellular sampling of the endometrial vault increases the sensitivity of adenocarcinoma detection.…”

Section: Introductionmentioning

confidence: 99%

The Role of Liquid-Based Preparation in the Evaluation of Endometrial Cytology

Norimatsu

Yanoh²,

Kobayashi³

2013

Acta Cytologica

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Objective: Liquid-based preparation (LBP) of the endometrial lesions is an important diagnostic tool for a variety of endometrial abnormalities because of its simplicity and high quali-quantitative diagnostic yield. We aimed to investigate the LBP method for endometrial cytology to evaluate both benign and abnormal endometrial lesions. Study Design: LBP is a semiautomated methodology that has recently become widely available and has gained popularity as a method of collecting and processing both gynecologic and nongynecologic cellular specimens. Results: Some peculiar endometrial cytoarchitectural features were described using LBPs. These were advantageous to screen as compared to conventional slides due to a smaller screening area and an excellent quality of cell preparations. Conclusions: LBP is a useful tool in the cellular diagnosis and follow-up of endometrial abnormalities, which remains complementary to the emerging molecular diagnostic cytopathology. The study of LBPs from endometrial cytology could be challenging since it is affected by numerous look-alikes and diagnostic pitfalls. This review discusses these various entities and takes into consideration the ancillary techniques that may be useful in the diagnostic procedure.

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“…Early-stage cases were significantly more frequent in the screening group (p < 0.001): 88.1% of the patients in the screening group had stage I disease, as compared to 65.3% of the patients in the outpatient group. The 5-year survival rate was also significantly higher in the screening group than in the outpatient group (94.7% vs 84.3%; p = 0.041) [3]. These statistics suggest that early detection of endometrial carcinoma and hyperplasia is necessary to improve the prognosis of these diseases.…”

Section: Introductionmentioning

confidence: 83%

Comparison of Two Sampling Procedures for Diagnosing Endometrial Carcinoma and Hyperplasia: Outpatient Tissue Biopsy Versus Cytologic Examination

Motegi¹,

Tanaka²,

Tada³

et al. 2011

J Cytol Histol

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IntroductionEach year, there are about 142,000 new cases of endometrial carcinoma worldwide, and an estimated 42,000 women die because of this type of cancer [1]. The surgical stage, determined according to the criteria of the International Federation of Gynecology and Obstetrics, reflects the 5-year survival, which is around 85% for stage I, 75% for stage II, 45% for stage III, and 25% for stage IV disease [1]. Endometrial cancer is often preceded by endometrial hyperplasia, which is a spectrum of morphologic and biologic alterations of the endometrial glands and stroma and is often secondary to hyperestrogenism. It has been shown that progression to carcinoma occurs in 1% of patients with simple hyperplasia, 3% of patients with complex hyperplasia, 8% of patients with simple hyperplasia with atypia, and 29% of patients with complex hyperplasia with atypia [2].The Japanese Ministry of Health and Welfare investigated the effectiveness of mass endometrial carcinoma screening. During the 9-year study, 126 cases were detected by mass screening and 1,069 cases were diagnosed in outpatient clinics. Early-stage cases were significantly more frequent in the screening group (p < 0.001): 88.1% of the patients in the screening group had stage I disease, as compared to 65.3% of the patients in the outpatient group. The 5-year survival rate was also significantly higher in the screening group than in the outpatient group (94.7% vs 84.3%; p = 0.041) [3]. These statistics suggest that early detection of endometrial carcinoma and hyperplasia is necessary to improve the prognosis of these diseases. AbstractBackground: We compared the sensitivity of 2 diagnostic procedures-tissue biopsy and cytologic examinationfor detecting endometrial carcinoma and hyperplasia in outpatients. The patients' degree of acceptance of these methods was also evaluated.

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Effectiveness of Mass Screening for Endometrial Cancer

Cited by 51 publications

References 7 publications

Evaluation of Endometrial Cytology: Cytohistological Correlations in 1,441 Cancer Patients

Evaluation of Endometrial Cytology: Cytohistological Correlations in 1,441 Cancer Patients

The Role of Liquid-Based Preparation in the Evaluation of Endometrial Cytology

Comparison of Two Sampling Procedures for Diagnosing Endometrial Carcinoma and Hyperplasia: Outpatient Tissue Biopsy Versus Cytologic Examination

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