Effectiveness of local radiotherapy in colorectal carcinoma

Rao, Aroor R.; Kagan, A. Robert; Chan, Paul Y. M.; Gilbert, Harvey A.; Nussbaum, Herman

doi:10.1002/1097-0142(197809)42:3<1082::aid-cncr2820420308>3.0.co;2-p

Cited by 34 publications

(4 citation statements)

References 18 publications

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“…Colorectal cancer is the third most common form of cancer worldwide and about half of the patients die of the disease in five years . Current treatments of late colorectal cancer are not always successful in terms of single therapy including chemotherapy and radiotherapy, which lead to distant metastasis, resistance, and local recurrence. , Therefore, radiotherapy combined with chemotherapy has attracted great interests from the basic research and clinical practice. , …”

Section: Introductionmentioning

confidence: 99%

Facile Deposition of Manganese Dioxide to Albumin-Bound Paclitaxel Nanoparticles for Modulation of Hypoxic Tumor Microenvironment To Improve Chemoradiation Therapy

et al. 2018

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Tumor microenvironment with hypoxia and excess hydrogen peroxide (HO) tremendously limits the effect of chemoradiation therapy of colorectal cancer. For the first time, we developed a facile method to deposit manganese dioxide (MnO) on the surface of albumin bound paclitaxel nanoparticles (ANPs-PTX) to obtain MnO-functioned ANPs-PTX (MANPs-PTX). In the tumor microenvironment, MANPs-PTX could consume excess hydrogen peroxide (HO) to produce abundant oxygen for tumor oxygenation and improve chemoradiation therapy. Meanwhile, the released Mn from MANPs-PTX had excellent T magnetic resonance imaging (MRI) performances for tumor detection. Notably, the obtained MANPs-PTX would be a promising theranostic agent and have potential clinical application prospects.

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Section: Introductionmentioning

confidence: 99%

Facile Deposition of Manganese Dioxide to Albumin-Bound Paclitaxel Nanoparticles for Modulation of Hypoxic Tumor Microenvironment To Improve Chemoradiation Therapy

et al. 2018

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“…The improvement in local [62] reported a 30% 2-year survival. More favorable results in 37 patients were reported from Kaiser Permanente [63]. With 24-84 months followup, 14% had no evidence of disease and the local failure rate was 51%.…”

Section: Subtotal Resection and Postoperative Rtmentioning

confidence: 91%

Management of Locally Unresectable Rectal Cancer

Minsky¹

2002

Colorectal Cancer

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The standard treatment for locally advanced/unresectable rectal cancer is preoperative radiation therapy followed by surgery. The primary goals of the preoperative treatment are to convert the cancer to a resectable status and to decrease the incidence of local failure. Phase I/II non-randomized data suggest that the most effective treatment is preoperative combined modality therapy followed by maximal surgical resection and intraoperative radiation therapy. In patients who cannot receive preoperative therapy, the use of maximal surgical resection plus intraoperative radiation therapy may be of benefit, however, it remains investigational.

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“…83 The real incidence and prevalence of tenesmus among a cancer population, especially in the palliative care setting, remain unknown. In patients with recurrent rectal carcinoma, the reported prevalence is around 14%, 84 but there are few reported statistics about this symptom and probably the real prevalence may be higher.…”

Section: Rectal Tenesmusmentioning

confidence: 99%