Effectiveness of imiquimod 5% cream for treatment of perianal warts in a 28‐month‐old child

Masuko, Takayuki; Fuchigami, Tatsuo; Inadomi, Toru; Inamo, Yasuji; Hashimoto, Koji

doi:10.1111/j.1442-200x.2010.03277.x

Cited by 9 publications

(10 citation statements)

References 11 publications

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“…The virus type does not provide proof for the presence or absence of sexual abuse in children. 10 , 14 Many treatment modalities have been evaluated in the adult population, but the treatment of extensive anogenital warts in children may be more challenging. No available drug therapy effectively eliminates HPV.…”

Section: Discussionmentioning

confidence: 99%

“…Imiquimod is usually well tolerated, and the side effects, which include local pain, erythema, pruritus, and irritation, are normally mild and limited to the site of application. 10 The advantage of imiquimod treatment for children includes the convenience of a generally well tolerated treatment that can be applied by the child’s parent or caregiver, usually painlessly, at home. Its use should be considered in children with extensive condyloma to avoid the pain and possible scarring associated with other approved treatment modalities.…”

Section: Discussionmentioning

confidence: 99%

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Giant condyloma acuminate due human papilloma virus type 16 in an infant successfully treated with topical imiquimod therapy

et al. 2015

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Anogenital warts related to human papillomavirus (HPV) have been observed in children. Definition of the transmission mode, therapy, and follow-up for long term potential complications is important. A 27-month old girl was admitted with multiple pedunculated red-purple colored cauliflower-like lesions of 1.5 years duration. Clinical/histopathological and microbiological diagnosis was condyloma acuminate due to HPV type 16. After 12 weeks of imiquimod 5% cream application (pea-sized) overnight three times per week, the perianal warts had completely disappeared. The mode of transmission of HPV 16 in our case was probably horizontal, related to the sharing of common personal hygiene items in the women’s shelter. We report herein the case of an infant living in a women’s shelter with giant condyloma acuminata due to HPV 16, which was successfully treated with topical imiquimod therapy. This patient should be followed up for recurrence and potential malignant lesions related to HPV type 16.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Giant condyloma acuminate due human papilloma virus type 16 in an infant successfully treated with topical imiquimod therapy

et al. 2015

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“…Systemic chemotherapy with methotrexate, bleomycin may be tried in extensive or recurrent BLT in adults. The use of imiquimod for pediatric anogenital condyloma was reported since 2001 with good results . Including our case, there were 10 girls and 10 boys and 90% of the patients achieved remission without recurrence.…”

mentioning

confidence: 54%

“…Including our case, there were 10 girls and 10 boys and 90% of the patients achieved remission without recurrence. In these reports, the duration of the treatment was from 3 weeks to 4 months . Hence, imiquimod 5% cream represents a novel treatment of BLT and is approved by the United States Food and drugs administration .…”

mentioning

confidence: 99%

Successful treatment with topical imiquimod of anal Buschke-Löwenstein tumor in a child

Zaouak

Hammami-Ghorbel

Koubaa

et al. 2015

Dermatologic Therapy

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Buschke-Lowenstein tumor (BLT) is a large exophytic lesion of the anogenital region with a clinically malignant aspect but a benign histology. Because of its low incidence, this pathology is exceptional in childhood. Surgical excision is the main therapeutic approach. Herein, we report a case of BLT successfully treated with imiquimod in a 2-year old boy. Young children with BLT should be offered a chance of medical treatment before extensive surgical destruction is used.

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“…Imiquimod is a recently developed imidazoquinoline heterocyclic amine that is an immune response modifier 2 7. Pulsed dye laser has been found to be safe, effective, satisfactory and less traumatic compared to other options for treatment of perianal warts in children 8.…”

Section: Discussionmentioning

confidence: 99%

Periurethral and vulval condylomata acuminata: an unusual juvenile venereal disease in a 3-year-old girl

Patel

Desai²,

Cherian³

et al. 2014

BMJ Case Reports

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We present a case of giant condyloma acuminatum (CA) in a 3-year-old girl with rapidly growing vulval and periurethral lesions, which was investigated thoroughly and successfully treated with excision biopsy. Genital warts in the form of giant alarming vestibular, vulval and periurethral lesions of CA are very rare in children. There is need for a multidisciplinary approach with potential sociomedicolegal implications. Surgical excision is safe, effective and provides an opportunity to assess the extent of the lesion and tissue for accurate diagnosis. Genital warts in the form of giant alarming vestibular, vulval and periurethral lesions of CA are very rare in children. Indications for surgical treatment include large, recurrent or refractory lesions, as well as the need for histological identification and acquiring tissue for immunotherapy when necessary. The strategy of an extended follow-up is recommended so as to ensure identification of any risk situations.

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Effectiveness of imiquimod 5% cream for treatment of perianal warts in a 28‐month‐old child

Cited by 9 publications

References 11 publications

Giant condyloma acuminate due human papilloma virus type 16 in an infant successfully treated with topical imiquimod therapy

Giant condyloma acuminate due human papilloma virus type 16 in an infant successfully treated with topical imiquimod therapy

Successful treatment with topical imiquimod of anal Buschke-Löwenstein tumor in a child

Periurethral and vulval condylomata acuminata: an unusual juvenile venereal disease in a 3-year-old girl

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