Effectiveness of <i>Curcuma longa</i> Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee Osteoarthritis

Wang, Zhiqiang; Jones, Graeme; Winzenberg, Tania; Cai, Guoqi; Laslett, Laura L; Aitken, Dawn; Hopper, Ingrid; Singh, Ambrish; Jones, Robert B.; Fripp, Jürgen; Ding, Changhai; Antony, Benny

doi:10.7326/m20-0990

Cited by 79 publications

(69 citation statements)

References 35 publications

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“…Most of the 15 RCTs were from different countries, among which Haroyan et al (2018) [ 31 ] came from Armenia, Wang et al (2020) [ 16 ] came from Australia, Henrotin et al (2019) [ 18 ] came from Belgium, Kertia et al (2012) [ 32 ] came from Indonesia and Nakagawa et al (2014) [ 36 ] came from Japan. In addition, three RCTs came from India [ 20 , 38–39 ], three RCTs came from Thailand [ 33 , 35 , 37 ] and four RCTs came from Iran [ 17 , 19 , 30 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…It may be supplementary evidence for the treatment of knee OA, but the quality of the included RCTs is limited, and the number is too small to make it impossible for definite clinical practice recommendations [ 15 ]. With the gradual increase in RCTs [ 16–20 ] and the accumulation of evidence, there is an urgent need to update the systematic review and meta-analysis. Therefore, this article will conduct a systematic review and meta-analysis on the efficacy and safety of curcumin intervention in OA based on the latest updated evidence.…”

Section: Introductionmentioning

confidence: 99%

“…Most of the 15 RCTs are from different countries, among which Haroyan et al 2018[31] comes from Armenia, Wang et al 2020[16] comes from Australia, Henrotin et al 2019[18] comes from…”

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confidence: 99%

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The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis

et al. 2021

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Objective: To assess the efficacy and safety of Curcuma longa Extract and curcumin supplements on osteoarthritis (OA). Methods: The databases such as Pubmed and Cochrane Library were searched to collect the article about Curcuma longa Extract and curcumin in the treatment of OA. Then, randomized controlled trials (RCTs) were selected and their data was extracted. Finally, the RevMan5.3 was utilized for risk of bias assessment and meta-analysis, the STATA15.0 were utilized for publication bias assessment, and GRADE tool were used for the evidence quality assessment of primary outcomes. Results: A total of 15 RCTs involving 1621 participants were included. (1) Compared with placebo, Curcuma longa Extract and curcumin (C.) can decrease the VAS and WOMAC score-pain, the WOMAC score-function and the WOMAC score-stiffness. In terms of adverse events, Curcuma longa Extract and curcumin are comparable to those of placebo. (2) Compared with NSAIDs, Curcuma longa Extract and curcumin have similar effects on joint pain, function and stiffness. The incidence of adverse events in Curcuma longa Extract and curcumin was lower. (3) Compared with the NSAIDs group, C.+NSAIDs can also decrease the VAS and WOMAC score-pain, the WOMAC score-function and the WOMAC score-stiffness. In terms of adverse events, the addition of Curcuma longa Extract and curcumin to NSAIDs did not increase adverse events. Conclusion: Curcuma longa Extract and curcumin may be a safer and effective supplement for OA patients. It is recommended to use Curcuma longa Extract and curcumin supplement for OA patients for more than 12 weeks.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis

et al. 2021

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“…A systematic review and metaanalysis of RCT enrolled 797 patients with primarily knee OA demonstrated that Curcuminoids had some beneficial effects on knee pain and quality of life in patients with knee OA (Onakpoya et al, 2017). Recently, a single-center, randomized, placebocontrolled trial with 12-week follow-up evaluated the efficacy of CL in patients with symptomatic knee OA and effusionsynovitis, and the results showed that CL was superior to placebo in relieving knee pain but did not affect the effusionsynovitis volume or cartilage composition as assessed by MRI (Wang et al, 2020). However, the follow-up time was relatively short so that it might be insufficient to detect a change in the cartilage-and synovium-specific outcomes in this study.…”

Section: Curcuma Longa Extractmentioning

confidence: 99%

New Trends in Pharmacological Treatments for Osteoarthritis

et al. 2021

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Osteoarthritis (OA) is the leading cause of function loss and disability among the elderly, with significant burden on the individual and society. It is a severe disease for its high disability rates, morbidity, costs, and increased mortality. Multifactorial etiologies contribute to the occurrence and development of OA. The heterogeneous condition poses a challenge for the development of effective treatment for OA; however, emerging treatments are promising to bring benefits for OA management in the future. This narrative review will discuss recent developments of agents for the treatment of OA, including potential disease-modifying osteoarthritis drugs (DMOADs) and novel therapeutics for pain relief. This review will focus more on drugs that have been in clinical trials, as well as attractive drugs with potential applications in preclinical research. In the past few years, it has been realized that a complex interaction of multifactorial mechanisms is involved in the pathophysiology of OA. The authors believe there is no miracle therapeutic strategy fitting for all patients. OA phenotyping would be helpful for therapy selection. A variety of potential therapeutics targeting inflammation mechanisms, cellular senescence, cartilage metabolism, subchondral bone remodeling, and the peripheral nociceptive pathways are expected to reshape the landscape of OA treatment over the next few years. Precise randomized controlled trials (RCTs) are expected to identify the safety and efficacy of novel therapies targeting specific mechanisms in OA patients with specific phenotypes.

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“…The most sensitive and reliable x-ray feature is joint space width, which is accepted by FDA to screen the efficacy of disease-modifying medications for osteoarthritis. Scoring systems (Kellgren and Lawrence (KL) and (OARSI) are of lower value than joint width [57].…”

Section: Imaging Studies Radiologymentioning

confidence: 99%

Pathophysiology of osteoarthritis and Current Treatment

Ali

2021

Zagazig Veterinary Journal

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Osteoarthritis (OA) is considered the prevalent arthritis in human and some animals, causing joint pain and disability that reduces quality of life. The exact etiology of OA is unknown till now but there is a variety of predisposing factors for the occurrence of osteoarthritis (OA) such as previous joint injury, genetics, obesity, sex, anatomical abnormalities and excessive load; meanwhile, the predominant factor is ageing. Understanding the pathophysiology of osteoarthritis is a must to provide effective treatment options. Previous researches had studied the pathophysiology of osteoarthritis However several controversies still present. Currently still there is no substantial therapy for OA; treatment options concentrate on the relief of signs. The main goals of therapy are pain relief, improved joint function, and joint stability. New trials of therapies are under study and some of them did promising effects as approaches to regenerative medical therapies such as Platelet Rich Plasma (PRP) and Nanotechnology. The purpose of this study is to provide an overview of pathophysiology information and of the various therapeutic resources suitable for OA.

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Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee Osteoarthritis

Cited by 79 publications

References 35 publications

The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis

The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis

New Trends in Pharmacological Treatments for Osteoarthritis

Pathophysiology of osteoarthritis and Current Treatment

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