Effectiveness of hyperbaric oxygen and ozone applications in tissue healing in generated soft tissue trauma model in rats: an experimental study

Yıldırım, Ali Osman; Eryılmaz, Mehmet; Kaldirim, Umit; Eyi, Yusuf Emrah; Tuncer, Salim Kemal; Eroğlu, Murat; Durusu, Murat; Topal, Turgut; Kurt, Bülent; Dilmen, Serkan; Bïlgïç, Serkan; Serdar, Muhittin

doi:10.5505/tjtes.2014.09465

Cited by 19 publications

(12 citation statements)

References 31 publications

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“…A total of 29 studies using HBOT for skin wound healing were included . Fourteen studies investigated HBOT for chronic wounds, 12 studies investigated HBOT in acute wounds, one study investigated HBOT in both chronic and acute wounds and two studies were performed in experimental wound models.…”

Section: Resultsmentioning

confidence: 99%

“…63 Yildirim et al used 63 rats with soft tissue trauma to investigate the effects of HBOT on edema, necrosis and inflammation. 53 A significant decrease in inflammation was detected in the HBO group compared to the control group. 53 T€ umerdem et al investigated the effect of HBOT on the survival of a full-thickness skin graft applied on a previously irradiated area.…”

Section: Case Seriesmentioning

confidence: 87%

“…53 A significant decrease in inflammation was detected in the HBO group compared to the control group. 53 T€ umerdem et al investigated the effect of HBOT on the survival of a full-thickness skin graft applied on a previously irradiated area. 62 There were no statistically significant differences in graft survival rate and histological findings.…”

Section: Case Seriesmentioning

confidence: 95%

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Oxygen therapies and their effects on wound healing

Smet

Kroese

Menon

et al. 2017

Wound Repair Regeneration

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Oxygen is an important factor for wound healing. Although several different therapies investigated the use of oxygen to aid wound healing, the results of these studies are not unequivocal. This systematic review summarizes the clinical and experimental studies regarding different oxygen therapies for promoting wound healing, and evaluates the outcomes according the methodological details. A systematic literature search was conducted using Embase, Medline, Web of Science, Cochrane, PubMed publisher, and Google Scholar libraries. Clinical and experimental studies investigating oxygen for wound healing were selected. Included articles were categorized according to the kind of therapy, study design, and wound type. The methodological details were extracted and analyzed. Sixty-five articles were identified and divided in three different oxygen therapies: Local oxygen therapy, hyperbaric oxygen therapy, and supplemental inspired oxygen therapy. More than half of the included local oxygen and hyperbaric oxygen studies had one or more significant positive outcomes, 77 and 63%, respectively. Supplemental inspired oxygen therapy during gastrointestinal and vascular surgery was more likely to have a positive result than during other surgical interventions reducing surgical site infections. These many positive outcomes promote the use of oxygen treatment in the stimulation of wound healing. However, the lack of clinical studies and vast methodological diversity made it impossible to perform a proper comparison within and between the different therapies. Further randomized clinical studies are warranted to examine the value of these therapies, especially studies that investigate the more patient-friendly oxygen dressings and topical wound oxygen therapies. Also, to achieve more solid and consistent data, studies should use more standardized methods and subjects.

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Section: Resultsmentioning

confidence: 99%

Section: Case Seriesmentioning

confidence: 87%

Section: Case Seriesmentioning

confidence: 95%

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Oxygen therapies and their effects on wound healing

Smet

Kroese

Menon

et al. 2017

Wound Repair Regeneration

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“…HBOT increases the expression of diverse growth factors and activates the hypoxia-inducible factor 1 (HIF-1) that may enhance angiogenesis and fibroblast proliferation [ 14 , 15 ]. In addition, most authors have indicated that the resulting hyperoxia may cause vasoconstriction, thereby decreasing tissue oedema [ 8 , 16 ], although this oedema decrease might be cause by an inflammation reduction after HBOT [ 17 ]. HBOT treatment also induces changes in the oxidative capabilities of immune cells, which can actively participate in the process of wound healing [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Response of Chronic Wounds to Hyperbaric Oxygen Therapy

et al. 2016

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We analyzed the effects of the clinical hyperbaric oxygen therapy (HBOT) on the plasma antioxidant response and levels of endothelin-1, Interleukine-6 (IL-6) and vascular endothelial growth factor (VEGF) in patients with chronic wounds (20.2±10.0 months without healing). They received 20 HBOT sessions (five sessions/week), and blood samples were obtained at sessions 1, 5 and 20 before and 2 hours after the HBOT. An additional blood sample was collected 1 month after wound recovery. Serum creatine kinase activity decreased progressively in accordance with the wound healing. Plasma catalase activity significantly increased after the first and fifth sessions of HBOT. Plasma myeloperoxidase activity reported significantly lower values after sessions. Plasma VEGF and IL-6 increased after sessions. Endothelin-1 levels were progressively decreasing during the HBOT, being significant at the session 20. Plasma malondialdehyde concentration was significantly reduced at the last session. Both creatine kinase activity and malondialdehyde levels were maintained lower 1 month after wound recovery respect to initial values. In conclusion, HBOT enhanced the plasma antioxidant defenses and may contribute to activate the healing resolution, angiogenesis and vascular tone regulation by increasing the VEGF and IL-6 release and the endothelin-1 decrease, which may be significant factors in stimulating wound healing.

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“…It leads to reductions in antioxidant levels and shocks in the body due to the stimulating effect of hydrogen peroxide. As a result of this effect, the defense system is stimulated and thus resistance to the oxidative process is increased, including antioxidant enzyme expression [ 14 ]. Ozone therapy can increase acute cutaneous wound healing and regulate other processes, such as inflammatory responses [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Use of Ozone to Treat Ileostomy Dermatitis in an Experimental Rat Model

et al. 2016

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BackgroundDermatitis associated with ileostomy is an important problem that affects many people, especially children. The aim of this study was to investigate the therapeutic effects of ozone on dermatitis due to ileostomy, and to develop an alternative treatment option.Material/MethodsA total of 28 rats were divided into 4 groups: control, ileostomy, ozone, and zinc oxide. Ileostomy was performed in all rats except the control group. After a 1-week waiting time, the ozone group was administered ozone therapy and the zinc oxide group was administered zinc oxide cream locally once a day for a total of 7 days. All rats were sacrificed at the end of this period. The efficacy of treatment was examined by biochemical, histopathological, and immunohistochemical parameters. The levels of malondialdehyde (MDA), total glutathione (tGSH), total antioxidant capacity (TAC), and total oxidant status (TOS) were measured from tissue. Vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) were examined immunohistochemically.ResultsDermatitis occurred pathologically in all rats that underwent ileostomy surgery. The lowest dermatitis score was in the ozone treatment group (p<0.05). Ileostomy dermatitis caused increased levels of MDA and TOS. Ozone treatment resulted in reduced MDA and TOS levels, while the levels of tGSH and TAC were increased (p<0.05). Both VEGF and PCNA immunostaining were augmented in the ozone treatment group (p<0.05).ConclusionsLocal ozone application may be a good alternative compared to the conventional treatment methods for the prevention of skin lesions that develop after ileostomy.

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Effectiveness of hyperbaric oxygen and ozone applications in tissue healing in generated soft tissue trauma model in rats: an experimental study

Abstract: BACKGROUND: Soft tissue trauma is a type of acute traumatic ischemia. We investigated in this study whether the edema, inflammation and ischemia caused by the trauma could be affected positively by hyperbaric oxygen (HBO) and ozone therapy.

Cited by 19 publications

References 31 publications

Oxygen therapies and their effects on wound healing

Oxygen therapies and their effects on wound healing

Antioxidant Response of Chronic Wounds to Hyperbaric Oxygen Therapy

Use of Ozone to Treat Ileostomy Dermatitis in an Experimental Rat Model

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