Effectiveness of Fixed-Dose Perindopril/Amlodipine on Clinic, Ambulatory and Self-Monitored Blood Pressure and Blood Pressure Variability: An Open-Label, Non Comparative Study in the General Practice

IuA, Karpov; Горбунов, В. М.; Деев, А. Д.

doi:10.1007/s40292-015-0117-0

Cited by 12 publications

(12 citation statements)

References 36 publications

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“…Provision of an automatic BP monitor [31] and optimization of the drug regimen using fixed combinations [11, 15, 16, 18, 19, 32, 33, 35, 36] found to be effective elsewhere [45, 46], were associated with a significant increase in adherence to AHT. However, in several of the studies adherence also improved in control groups, most likely because both groups received a series of enhancements to treatment including self-monitoring diaries, and written recommendations on lifestyle changes, as well as intensive monitoring of both groups for the entire period of follow-up.…”

Section: Discussionmentioning

confidence: 99%

Adherence to antihypertensive medication in Russia: a scoping review of studies on levels, determinants and intervention strategies published between 2000 and 2017

et al. 2019

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Background Arterial hypertension (HT) is common in the Russian adult population, with half of affected individuals inadequately controlled. Low adherence to medication seems likely to be a factor. We report a scoping review of studies on adherence to antihypertensive therapy (AHT) in Russia to determine the extent of research undertaken, the frequency of adherence among adults diagnosed with HT, methodologies used in the studies, and their ability to describe determinants of adherence. Methods A scoping review of published studies that have assessed adherence to AHT in Russian HT patients searched the main Russian and international electronic databases eLIBRARY.ru, Russian Medicine, Embase, MEDLINE for full-text reports published in the Russian language between 2000 and 2017. The last search was on November 28, 2017. Among 520 reports identified, 31 were included in the review. Results Eighteen studies assessed adherence using the 4-item Morisky Medication Adherence Scale (MMAS-4); others used bespoke questionnaires or pill counts. 25 studies assessed levels of adherence, 11 examined its determinants, and 18 examined intervention strategies. The proportion of “adherent” patients varied from 11 to 44% using the MMAS-4, from 23 to 74% when using bespoke questionnaires, and from 5 to 43% when using pill counts. Adherence was associated with sociodemographic factors, access to free drugs provided through the Medicine Assistance Scheme (MAS), use of home blood pressure (BP) monitoring, anxiety, and comorbidity. There was no evidence that adherence was associated with income or physical activity. Evidence of an association between MAS, grade of HT, or experience of hypertensive crisis was inconclusive. Various methods to improve adherence were studied including patient education (improved from 1.8 to 3.9 points, p = 0.0002 or 2.80 to 3.79 points, p < 0.0001 measured by the MMAS-4), telephone reminders (p < 0.0001), training in home BP monitoring (p < 0.05), and use of fixed-dose combinations (p < 0.05). Conclusions The main determinants of adherence to AHT are sociodemographic characteristics, the severity of HT, and presence of comorbidity. Patient education and use of fixed-dose combinations of drugs were identified as most important for improving adherence. Most studies assessing adherence use self-reported methods so there is a need for greater use of objective methods. Trial registration This scoping review has not been registered.

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Section: Discussionmentioning

confidence: 99%

Adherence to antihypertensive medication in Russia: a scoping review of studies on levels, determinants and intervention strategies published between 2000 and 2017

et al. 2019

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“…For instance, calcium channel blockers, thiazide diuretics can improve BPV at different levels. The effect of angiotensin converting enzyme inhibitors, angiotensin receptor blockers on BPV is inconsistent, and β-blockers could increase BPV [28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Relationship between carotid artery sclerosis and blood pressure variability in essential hypertension patients

Xianglin

Zhan

et al. 2018

Computers in Biology and Medicine

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Objectives: This study aimed to investigate the relationship between the presence of carotid arteriosclerosis (CAS) and blood pressure variability (BPV) in patients with essential hypertension. Methods:One hundred and forty four essential hypertension patients underwent ambulatory BP monitoring for 24 hours after hospitalization. Common BPV metrics were calculated. General clinical parameters, including age, gender, height, weight, history of coronary heart disease, stroke, diabetes, hypertension, smoking and drink, were recorded. Biochemical indices were obtained from a blood test. Carotid intima-media thickness (IMT) and carotid plaques were assessed to separate patients into a non-CAS group (IMT0.9 mm; n=82) and a CAS group (IMT>0.9 mm; n=62). BPV metrics and clinical parameters were analyzed and compared between the two groups.

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“…The ABPM substudy of PEARL (PErindopril/Amlodipine Reduction of blood pressure Level), a 3-month observational study, demonstrated a statistically significant reduction in systolic and diastolic withinindividual visit-to-visit BP variability, as assessed by the systolic and diastolic BP coefficient of variation, from 10.5/13.5% at baseline to 8.2/11.7% (P < 0.01) after 3 months [73]. In addition, an open-label study in general practice which examined the effect on BP of substituting current ineffective antihypertensive treatment with a fixed-dose combination of perindopril/amlodipine in patients with uncontrolled hypertension showed that target BP levels were achieved in the majority of patients at 3 months, with additional beneficial effects on various parameters related to BP variability [74].…”

Section: Indexmentioning

confidence: 99%

Current challenges for hypertension management: From better hypertension diagnosis to improved patients' adherence and blood pressure control

Parati

Lombardi

Pengo

et al. 2021

International Journal of Cardiology

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Blood pressure control Home blood pressure monitoring Ambulatory blood pressure monitoring Treatment adherence BP telemonitoring Mobile health technologiesHypertension control still remains a largely unmet challenge for public health systems. Despite the progress in blood pressure (BP) measurement techniques, and the availability of effective and safe antihypertensive drugs, a large number of hypertensive patients are not properly identified, and a significant proportion of those who receive antihypertensive treatment fail to achieve satisfactory control of their BP levels. It is thus not surprising that hypertension is still a major contributor to disease burden and disability worlwide, even in developed countries. This paper will address current challenges in hypertension management and potential strategies for an improvement in this field. In its first part relevant issues related to hypertension diagnosis will be addressed, in particular how to improve identification of sustained BP elevation and specific BP phenotypes such as white coat and masked hypertension trough the combined use of office and out-of-office BP monitoring techniques. In its second part focus will be on how to improve achievement of hypertension control in treated patients by optimization and simplification of medication regimens, including more efficient selection and titration of antihypertensive drugs and their combinations, aimed at achieving a more consistent 24hBP control; and by favoring a more active patients' and physicians' involvement in hypertension management also through BP telemonitoring and mobile health technologies.

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Effectiveness of Fixed-Dose Perindopril/Amlodipine on Clinic, Ambulatory and Self-Monitored Blood Pressure and Blood Pressure Variability: An Open-Label, Non Comparative Study in the General Practice

Cited by 12 publications

References 36 publications

Adherence to antihypertensive medication in Russia: a scoping review of studies on levels, determinants and intervention strategies published between 2000 and 2017

Adherence to antihypertensive medication in Russia: a scoping review of studies on levels, determinants and intervention strategies published between 2000 and 2017

Relationship between carotid artery sclerosis and blood pressure variability in essential hypertension patients

Current challenges for hypertension management: From better hypertension diagnosis to improved patients' adherence and blood pressure control

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