Effectiveness of eight-week zinc supplementation on vitamin D3 status and leptin levels in a population of postmenopausal women: a double-blind randomized trial

Vázquez-Lorente, Héctor; Molina-López, Jorge; Herrera-Quintana, Lourdes; Gamarra-Morales, Yénifer; López-González, Beatriz; Planells, Elena

doi:10.1016/j.jtemb.2021.126730

Cited by 7 publications

(2 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mineral variables (i.e., Fe, Zn, Cu, and Mn) were analyzed using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) (Perkin Elmer® SCIEX Elan-5000 equipment, Markham, Ontario, Canada) following a previous wet-mineralized way in the Scienti c Instrumentation Center from the University of Granada -which provided the references values -as previously described 22 .…”

Section: Assessment Of Biochemical and In Ammatory Parameters And Min...mentioning

confidence: 99%

Changes in trace elements and metallothioneins levels and their relationship with clinical, biochemical, and inflammatory parameters in patients with COVID-19 during the early ICU phase

Herrera-Quintana

Vázquez-Lorente

Gamarra-Morales

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Background The levels of trace elements and Metallothioneins (MTs) could play a key role in modulating the inflammatory reaction and pathogenesis of COVID-19. Their effects on clinical variables are of interest for the characterization and management of this disease. Thus, the present study aimed to investigate the association between circulating Iron (Fe), Zinc (Zn), Copper (Cu), Manganese (Mn), and MTs levels, as well as their relationship with clinical, biochemical, and inflammatory parameters in critical care patients with COVID-19 at early Intensive Care Unit (ICU) phase. Methods A total of 86 critically ill patients with COVID-19 were monitored from the first day of admission to the ICU until the third day of stay. Clinical parameters were retrieved from the hospital database. Biochemical and inflammatory parameters were analyzed following enzymatic colorimetry and immunoassay procedures. Serum samples were used to assess mineral levels by inductively coupled plasma-mass spectrometry and MTs levels by differential pulse voltammetric. Results Levels of Cu and MTs decreased (all P ≤ 0.046) after 3 days of ICU stay, increasing the prevalence of Cu deficient values from 50–65.3% (P = 0.015) on the third day of ICU stay. Fe and Zn were shown to have a predictive value for mortality and severity. Changes in Fe were directly related to changes in Cu and Mn (all r ≥ 0.266; P ≤ 0.019). In contrast, changes in MTs were inversely related to changes in Mn and albumin (all r≥–0.255; P ≤ 0.039). Conclusions The present study indicated a risk of trace element deficiencies related to different biochemical and clinical parameters. We suggest monitoring the mineral status and performing nutritional interventions, when appropriate, that could help to improve the altered parameters, such as inflammatory conditions and, thus, the prognosis in critically ill patients with COVID-19.

show abstract

Section: Assessment Of Biochemical and In Ammatory Parameters And Min...mentioning

confidence: 99%

Changes in trace elements and metallothioneins levels and their relationship with clinical, biochemical, and inflammatory parameters in patients with COVID-19 during the early ICU phase

Herrera-Quintana

Vázquez-Lorente

Gamarra-Morales

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…In a study conducted on 988 adolescent girls (12–18 years old), low blood zinc level was found to be a strong predictor of vitamin D deficiency (serum levels <20 ng) ( Gonoodi et al, 2019 ). In a double-blind randomized trial, eight-week of zinc supplementation increased vitamin D levels in postmenopausal women ( V á zquez-Lorente et al, 2021 ). In a similar line of study, a positive association between the serum levels of zinc and vitamin D has been documented among children and adolescents, and the odds of higher levels of vitamin D increased with higher levels of zinc ( Shams et al, 2016 ).…”

Section: Zinc and Vitamin D Interactionsmentioning

confidence: 99%

Zinc and its role in vitamin D function

Amos

2022

Current Research in Physiology

View full text Add to dashboard Cite

Synergistic effect of ZnO NPs and imidacloprid on liver injury in male ICR mice: Increase the bioavailability of IMI by targeting the gut microbiota

Yan

Tian

Meng

et al. 2022

Environmental Pollution

View full text Add to dashboard Cite

Effectiveness of eight-week zinc supplementation on vitamin D3 status and leptin levels in a population of postmenopausal women: a double-blind randomized trial

Cited by 7 publications

References 46 publications

Changes in trace elements and metallothioneins levels and their relationship with clinical, biochemical, and inflammatory parameters in patients with COVID-19 during the early ICU phase

Changes in trace elements and metallothioneins levels and their relationship with clinical, biochemical, and inflammatory parameters in patients with COVID-19 during the early ICU phase

Zinc and its role in vitamin D function

Synergistic effect of ZnO NPs and imidacloprid on liver injury in male ICR mice: Increase the bioavailability of IMI by targeting the gut microbiota

Contact Info

Product

Resources

About