Effectiveness of denture microwave disinfection for treatment of denture stomatitis: A systematic review and meta‐analysis

Abstract

Objective The aim of this systematic review was to evaluate the effectiveness of removable complete denture disinfection using microwaves for the treatment of denture stomatitis. Methods This review identified studies comparing the efficacy of microwave prosthesis disinfection (I) to topical antifungal therapy (C) in the treatment of denture stomatitis (O), which included only individuals who used complete dentures and presented with denture stomatitis (P). The search was performed in six databases and identified 1524 records; after the removal of duplicates, 816 articles remained. Three articles were selected for qualitative synthesis and two for meta‐analysis. Random‐effects meta‐analysis estimated the polled effects of microwave disinfection and antifungal therapy on the Candida counts and clinical manifestation of denture stomatitis. The GRADE approach was used to estimate the certainty of evidence. Results All included studies reported significant reductions in Candida counts and the frequency of denture stomatitis of groups subjected to microwave disinfection of dentures and topical antifungal therapy with nystatin. Significative differences between treatments were only detected for Candida quantification in the palate, within 90 days follow‐up period (SMD = 0.47, 95% CI = 0.02–0.91). Meta‐analyses did not show any further differences between treatments (p > .05), considering the Candida quantification in dentures and the frequency of clinical signs of denture stomatitis. The certainty of the evidence was considered as low, according to GRADE approach. Conclusion Microwave disinfection of complete dentures can be considered as efficient as antifungal therapy for the treatment of denture stomatitis. However, further well‐designed studies are necessary to confirm such evidence.

Experimental animal models for denture stomatitis: A methodological review

“…2 To date, there is no gold standard in the management of denture stomatitis, 3 and the high recurrence rate makes the investigation of new treatments a must. 1 However, prior to clinical studies, it is crucial to guarantee that any alternative treatment is safe and effective. 4 Alternative methods, such as invertebrate models 5,6 and non-animal models, 7,8 are ethically acceptable, have a good correlation to animal models, and do not require specialized facilities and personnel for maintenance.…”

“…Denture stomatitis is a chronic inflammatory condition characterized by edema and erythema of the mucosa underlying removable dental prostheses. 1 Despite having a complex pathogenesis, infection by Candida albicans is often considered its main etiological factor. 2 To date, there is no gold standard in the management of denture stomatitis, 3 and the high recurrence rate makes the investigation of new treatments a must.…”

“…2 To date, there is no gold standard in the management of denture stomatitis, 3 and the high recurrence rate makes the investigation of new treatments a must. 1 However, prior to clinical studies, it is crucial to guarantee that any alternative treatment is safe and effective. 4…”

Evaluation of Occlusal Pressure Pattern and Dimensional Changes of the Lined Dentures Subjected to Microwave Disinfection Protocol

“…The microwave irradiation is considered to be an easy, efficient and low-cost technique for denture disinfection with antifungal effect, it was used for post-polymerization denture base treatment, to decrease acrylic resins residual monomer amount (18,19) . Also, denture wearer patients suffer from oral candidiasis would use microwave irradiation for denture disinfection (20) .…”

“…Also, denture wearer patients suffer from oral candidiasis would use microwave irradiation for denture disinfection (20) . It has disinfection effect against candida albicans, and other candida species that inoculated into acrylic resin dentures (18,21) .…”