Effectiveness of Delayed Enhanced MRI for Identification of Cardiac Sarcoidosis: Comparison with Radionuclide Imaging

Abstract

Delayed enhanced MRI is considered a useful method for the early identification of cardiac sarcoidosis. Delayed hyperenhancement is frequently associated with a reduction of regional wall motion and thallium-201 perfusion defects.

Free‐breathing high‐spatial‐resolution delayed contrast‐enhanced three‐dimensional viability MR imaging of the myocardium at 3.0T: A feasibility study

“…DELAYED CONTRAST-ENHANCED VIABILITY magnetic resonance imaging (MRI) of the myocardium is a valuable tool for the detection of myocardial infarction (MI), various types of cardiomyopathies, and postinterventional findings (1)(2)(3)(4)(5)(6)(7)(8). Because of its high spatial resolution and image contrast, viability MRI visualizes the subendocardial MI and myocardial damage associated with hypertrophic cardiomyopathy (HCM) and sarcoidosis that cannot be detected with other imaging modalities (5)(6)(7).…”

“…Because of its high spatial resolution and image contrast, viability MRI visualizes the subendocardial MI and myocardial damage associated with hypertrophic cardiomyopathy (HCM) and sarcoidosis that cannot be detected with other imaging modalities (5)(6)(7). The transmural extension of MI and myocardial fibrosis in HCM assessed using delayed contrast-enhanced viability imaging are strongly related to regional and global cardiac function, remodeling, and indications for revascularization (1,4,6).…”

“…A standard viability MRI technique is breath-hold two-dimensional (2D) inversion-recovery gradientecho imaging that starts 10 -20 minutes after an injection of gadolinium (1)(2)(3)6,7). However, there are some disadvantages related to the breath-hold 2D imaging sequences: a number of repeated breathholds are required to cover the whole heart and to acquire several imaging planes because of no availability for multiplanar reconstruction, and slices can be misregistered (9,10).…”

Comparison of Contrast-Enhanced MRI with 18F-FDG PET/201Tl SPECT in Dysfunctional Myocardium: Relation to Early Functional Outcome After Surgical Revascularization in Chronic Ischemic Heart Disease

“…Recently, MRI has been considered to accurately assess the cardiac function, viability, and perfusion in 1 examination (14)(15)(16)(17). However, there is limited information on viability detected by 18 F-FDG PET or contrast-enhanced MRI in the prediction of early function outcome after surgical revascularization. We hypothesized that differences between contrast-enhanced MRI and 18 F-FDG PET/ 201 Tl SPECT tissue characterization of myocardium might be related to both the recovery and nonrecovery of function and the rate of recovery of function after surgical revascularization and, furthermore, that the combination of MRI and nuclear techniques could be incrementally beneficial for predicting segmental functional recovery.…”

Diagnostic and Therapeutic Management of Cardiac Sarcoidosis -Application of High Resolution Electrocardiography

“…Cardiac MRI has been reported to be useful for detecting areas of inflammation associated with sarcoid granulomas (Shimada et al, 2001). Several reports have shown high sensitivity (100%) and specificity (78% and 100%) for diagnosis of CS (Smedema et al, 2005;Tadamura et al, 2005). However, one of the main disadvantages is that MRI is not recommended for patients with implantable cardiac devices, such as pacemaker, or implantable cardioverter-defibrillator (ICD).…”