Effectiveness of curcumin mouthwash on radiation-induced oral mucositis among head and neck cancer patients: A triple-blind, pilot randomised controlled trial

Shah, Swikant; Rath, Hemamalini; Sharma, Gaurav; Senapati, Surendra Nath; Mishra, Ekagrata

doi:10.4103/ijdr.ijdr_822_18

Cited by 37 publications

(25 citation statements)

References 3 publications

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“…In contrast, payayor and fingerroot mouthwashes analyzed by Kongwattanakul et al [ 11 ], Cystus tea mouthwash used by Ebert et al [ 15 ], green tea mouthwash used by Liao et al [ 16 ], propolis mouthwash by Hamzah et al [ 18 ], and curcumin mouthwash studied by Shah et al [ 21 ] have been shown to be equally effective compared to placebo mouthwash, especially when assisted with cryotherapy and laser or light therapy [ 16 ]. The multicenter study by De Sanctis et al [ 17 ] also found no differences in the onset and severity of radio-induced mucositis with Lactobacillus brevis CD2 supplementation.…”

Section: Resultsmentioning

confidence: 99%

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Management of Oral Hygiene in Head-Neck Cancer Patients Undergoing Oncological Surgery and Radiotherapy: A Systematic Review

et al. 2023

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Background: In the literature, among oral health prevention programs dedicated to cancer patients, a wide heterogeneity is evident. The purpose of this work is to analyze the available scientific evidence for the treatment of head and neck cancer (HNC) patients undergoing resective surgery and radiotherapy and to draw up a diversified oral hygiene protocol during oncological therapy. Methods: PubMed was used as database. Studies published from 2017 to September 2022 were analyzed. Studies investigating the effectiveness of the preventive procedures carried out by the dental professionals in HNC patients undergoing postoperative adjuvant therapy have been taken into account. Results: The application of the search string on PubMed allowed the selection of 7184 articles. The systematic selection of articles led to the inclusion of 26 articles in this review, including 22 RCTs, 3 observational studies, and 1 controlled clinical study. Articles were divided according to the debated topic: the management of radiation-induced mucositis, xerostomia, the efficacy of an oral infection prevention protocol, and the prevention of radiation-induced caries. Conclusions: Dental hygienists are fundamental figures in the management of patients undergoing oncological surgery of the maxillofacial district. They help the patient prevent and manage the sequelae of oncological therapy, obtaining a clear improvement in the quality of life.

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Section: Resultsmentioning

confidence: 99%

“…Eight studies were judged at high risk of bias (M.J. Dodd (2022) [ 13 ]; N. Ebert et al (2021) [ 15 ]; M.H. Hamzah et al (2022) [ 18 ]; A. Lozano et al (2021) [ 19 ]; S. Shah et al (2020) [ 21 ]; Y. Jun et al (2022) [ 23 ]; O. Apperley et al (2017) [ 28 ]; A. Lam-ubol et al (2021) [ 29 ]; H.O. Sohn et al (2018) [ 35 ]).…”

Section: Resultsmentioning

confidence: 99%

Management of Oral Hygiene in Head-Neck Cancer Patients Undergoing Oncological Surgery and Radiotherapy: A Systematic Review

et al. 2023

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“…Further, nanocurcumin formulation from Theravalues Corp., Japan was demonstrated to downregulate IL-6, hs-CRP, MDA, and upregulate IL-10, brain-derived neurotrophic factor (BDNF), and TAC in MetS patients . Furthermore, several other nanocurcumin formulations have also been developed by various laboratories and these formulations have shown tremendous potential in helping healthy subjects and treating various chronic diseases such as arthritis, cancer, NAFLD, neurological disorders, oral diseases, and skin diseases. − Thus, nanocurcumin formulation with enhanced bioavailability and safety has been promising in treating several human diseases.…”

Section: Curcumin Formulationsmentioning

confidence: 99%

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

et al. 2023

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Curcumin has been credited with a wide spectrum of pharmacological properties for the prevention and treatment of several chronic diseases such as arthritis, autoimmune diseases, cancer, cardiovascular diseases, diabetes, hemoglobinopathies, hypertension, infectious diseases, inflammation, metabolic syndrome, neurological diseases, obesity, and skin diseases. However, due to its weak solubility and bioavailability, it has limited potential as an oral medication. Numerous factors including low water solubility, poor intestinal permeability, instability at alkaline pH, and fast metabolism contribute to curcumin’s limited oral bioavailability. In order to improve its oral bioavailability, different formulation techniques such as coadministration with piperine, incorporation into micelles, micro/nanoemulsions, nanoparticles, liposomes, solid dispersions, spray drying, and noncovalent complex formation with galactomannosides have been investigated with in vitro cell culture models, in vivo animal models, and humans. In the current study, we extensively reviewed clinical trials on various generations of curcumin formulations and their safety and efficacy in the treatment of many diseases. We also summarized the dose, duration, and mechanism of action of these formulations. We have also critically reviewed the advantages and limitations of each of these formulations compared to various placebo and/or available standard care therapies for these ailments. The highlighted integrative concept embodied in the development of next-generation formulations helps to minimize bioavailability and safety issues with least or no adverse side effects and the provisional new dimensions presented in this direction may add value in the prevention and cure of complex chronic diseases.

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“…Se han realizado varios estudios acerca de agentes tópicos, principalmente en presentación de enjuagues bucales, utilizados con fines preventivos para la RIOM 18,[22][23][24] .…”

Section: Manejo Preventivo Para La Mucositis Oralunclassified

“…La bencidamina es un agente con propiedades antiinflamatorias, analgésicas y antimicrobianas que tiene fuerte respaldo en la prevención de la RIOM en pacientes que reciben dosis moderadas de radioterapia 22,23 . Sin embargo, tiene poco efecto cuando la dosis de radiación es igual o mayor a 50 Gy y cuando, conjuntamente, se aplica quimioterapia 18 .…”

Section: Manejo Preventivo Para La Mucositis Oralunclassified

Manejo odontológico de las manifestaciones orales inducidas por radioterapia de cabeza y cuello

Mejía-Chuquispuma

Flores-Jiménez

Castro-Auqui

et al. 2023

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La radioterapia es una de las primeras opciones de tratamiento para el cáncer de cabeza y cuello; sin embargo, puede ocasionar diversas manifestaciones secundarias en la cavidad oral tales como mucositis oral, xerostomía, infecciones orales oportunistas, osteorradionecrosis y trismo. El presente artículo tiene como objetivo describir el manejo preventivo y terapéutico de las complicaciones orales inducidas por radioterapia de cabeza y cuello en la práctica odontológica propuestos hasta la actualidad. Se encontraron diversas medidas que han logrado reducir la incidencia y gravedad de dichas manifestaciones orales; sin embargo, aún existen algunas que requieren de más estudios para confirmar su efectividad. Palabras clave: cáncer de cabeza y cuello; manifestaciones bucales; radioterapia; terapéutica.

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Effectiveness of curcumin mouthwash on radiation-induced oral mucositis among head and neck cancer patients: A triple-blind, pilot randomised controlled trial

Cited by 37 publications

References 3 publications

Management of Oral Hygiene in Head-Neck Cancer Patients Undergoing Oncological Surgery and Radiotherapy: A Systematic Review

Management of Oral Hygiene in Head-Neck Cancer Patients Undergoing Oncological Surgery and Radiotherapy: A Systematic Review

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

Manejo odontológico de las manifestaciones orales inducidas por radioterapia de cabeza y cuello

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