Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation

Candow, Darren G.; Forbes, Scott C.; Chilibeck, Philip D.; Cornish, Stephen M.; António, José; Kreider, Richard B.

doi:10.3390/jcm8040488

Cited by 87 publications

(82 citation statements)

References 101 publications

(138 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Higher doses of calcium associate with greater bone mineral density too, and given bone is the largest depot of calcium in the body, it seems imperative to maintain sufficient intake with age, despite the debate of this micronutrient in lowering fracture risk . Creatine is another nutrient that has consistently been shown to enhance muscle mass, strength, and function and may be a promising strategy to preserve bone microarchitecture and strength, although investigations have largely been conducted in healthy older adults.…”

Section: Translational Geroscience and Osteosarcopeniamentioning

confidence: 99%

Osteosarcopenia: A case of geroscience

2019

View full text Add to dashboard Cite

Global aging, attributed to advancements in health care and socioeconomic factors, represents one of the great achievements of the 21st century. However, older age associates with chronic diseases, which could share similar pathophysiology and risk factors; understanding and elucidation of those common mechanisms have enabled the development of geroscience. Musculoskeletal diseases, in particular, represent a significant burden in older persons and a major cost to health systems worldwide. Of those, osteopenia/osteoporosis (characterized by low bone mass) increases with age alongside the number of osteoporotic fractures, 1 while sarcopenia (low muscle mass and function) confers a high risk of falls and disability in older persons. 2 Together, these diseases form a geriatric syndrome known as "osteosarcopenia," 3 which associates with an increased risk of falls, fractures, and hospitalizations in older persons. 4,5 Not only does osteosarcopenia induce billions in health-care expenditure but it also greatly impairs an older person's quality of life. 3,6

show abstract

Section: Translational Geroscience and Osteosarcopeniamentioning

confidence: 99%

Osteosarcopenia: A case of geroscience

2019

View full text Add to dashboard Cite

show abstract

“…Separately, creatine is essential for muscle ATP production and has been commonly ingested to enhance anabolic response to exercise. Multiple studies have presented some evidence that creatine treatment, in combination with resistance training, enhances gains in muscle mass and strength following exercise beyond what is attainable with resistance exercise alone (Candow et al, 2019). The benefit of creatine therapy alone without resistance training remains unclear; some have suggested that creatine ingestion improves lean muscle mass in the elderly (Gotshalk et al, 2002), whereas others have observed no benefit in muscle mass or strength with creatine administration (Lobo et al, 2015;Baker et al, 2016;Chami and Candow, 2019).…”

Section: Nutritional Supplementationmentioning

confidence: 99%

Optimizing Skeletal Muscle Anabolic Response to Resistance Training in Aging

2020

View full text Add to dashboard Cite

Loss of muscle mass and strength with aging, also termed sarcopenia, results in a loss of mobility and independence. Exercise, particularly resistance training, has proven to be beneficial in counteracting the aging-associated loss of skeletal muscle mass and function. However, the anabolic response to exercise in old age is not as robust, with blunted improvements in muscle size, strength, and function in comparison to younger individuals. This review provides an overview of several physiological changes which may contribute to age-related loss of muscle mass and decreased anabolism in response to resistance training in the elderly. Additionally, the following supplemental therapies with potential to synergize with resistance training to increase muscle mass are discussed: nutrition, creatine, anti-inflammatory drugs, testosterone, and growth hormone (GH). Although these interventions hold some promise, further research is necessary to optimize the response to exercise in elderly patients.

show abstract

“…Creatine is an organic compound naturally produced in the body from reactions involving the amino acids arginine, glycine and methionine in the kidneys and liver or consumed in the diet primarily from red meat, poultry, seafood [ 1 ] or supplementation practices. There is substantial evidence that creatine supplementation and resistance training increases muscle mass and performance (i.e., strength) more than placebo and resistance training, possibly by influencing phosphate metabolism, cellular hydration status, calcium and protein kinetics, glycogen content, satellite cells, growth factors, inflammation and oxidative stress (for reviews see [ 2 , 3 , 4 , 5 , 6 ]).…”

Section: Introductionmentioning

confidence: 99%

Effects of Creatine Supplementation during Resistance Training Sessions in Physically Active Young Adults

et al. 2020

Self Cite

View full text Add to dashboard Cite

The purpose was to examine the effects of creatine supplementation during resistance training sessions on skeletal muscle mass and exercise performance in physically active young adults. Twenty-two participants were randomized to supplement with creatine (CR: n = 13, 26 ± 4 yrs; 0.0055 g·kg−1 post training set) or placebo (PLA: n = 9, 26 ± 5 yrs; 0.0055 g·kg−1 post training set) during six weeks of resistance training (18 sets per training session; five days per week). Prior to and following training and supplementation, measurements were made for muscle thickness (elbow and knee flexors/extensors, ankle plantarflexors), power (vertical jump and medicine ball throw), strength (leg press and chest press one-repetition maximum (1-RM)) and muscular endurance (one set of repetitions to volitional fatigue using 50% baseline 1-RM for leg press and chest press). The creatine group experienced a significant increase (p < 0.05) in leg press, chest press and total body strength and leg press endurance with no significant changes in the PLA group. Both groups improved total body endurance over time (p < 0.05), with greater gains observed in the creatine group. In conclusion, creatine ingestion during resistance training sessions is a viable strategy for improving muscle strength and some indices of muscle endurance in physically active young adults.

show abstract

Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation

Cited by 87 publications

References 101 publications

Osteosarcopenia: A case of geroscience

Osteosarcopenia: A case of geroscience

Optimizing Skeletal Muscle Anabolic Response to Resistance Training in Aging

Effects of Creatine Supplementation during Resistance Training Sessions in Physically Active Young Adults

Contact Info

Product

Resources

About