Effectiveness of Computed Tomography in the Diagnosis of Novel Coronavirus-2019

Yurdaışık, Işıl

doi:10.7759/cureus.8134

Cited by 8 publications

(8 citation statements)

References 25 publications

(32 reference statements)

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“…A CT of the chest is used as the main imaging tool in doubtful cases and is a valuable tool for supervising the changes and reflecting the severity during treatment. 9 Abnormal findings in CT can be present even in asymptomatic patients; therefore, combining imaging assessment with clinical and laboratory results could favour precocious diagnosis of COVID-19. 10 The severity of lung involvement on high resolution CT correlates positively with laboratory findings, and this provides an insight into the appropriate interval of chest CT to reduce radiation exposure and support proper management of patients with COVID- 19.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Neutrophil-Lymphocyte Ratio, Platelets-Lymphocyte Ratio, and High-Resolution CT in Patients with COVID-19

et al. 2023

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Background: COVID-19 is a highly infectious disease that necessitates simple and rapid methods for recognising severe patients. Aims: To correlate between chest lesions in CT, neutrophil-lymphocyte ratio (NLR), and platelets-lymphocytes ratio in patients with COVID-19, and to detect their cut-off values as an early warning of severe COVID-19 in Egyptian patients. Subjects and Methods: A cross-sectional study included 100 adult patients with COVID-19 attending Ahmed Maher Teaching Hospital, Cairo, Egypt. Clinical, laboratory, and radiological assessments were done. They were classified according to their CT grades into three groups: seven patients with a normal chest CT, 45 non-severe cases, and 48 severe cases. Results: Dyspnoea was the most common symptom among the severe cases (79.2%) and fever among non-severe cases (71.1%), while cough (85.7%) was the most common among cases with a normal CT. The age, NLR, C-reactive protein (CRP), and D-dimer of severe cases were significantly the highest, while the absolute lymphocytes were significantly the lowest. Highly significant positive correlations were found between CT grades with D-dimer, NLR, and CRP; significant positive correlation was found with age; and significant negative correlation with CT. Using receiver operating characteristic analysis, areas under the curve of D-dimer, NLR, age, CRP, ferritin, and platelet-lymphocyte ratio were 0.760, 0.698, 0.640, 0.627, 0.614, and 0.595, respectively. The optimal cut-off value of NLR was 2.50 with 0.74 specificity, 0.61 sensitivity, and 67.5 accuracy. Conclusion: NLR is a reliable and easy-to-use predictor of COVID-19 severity. NLR (>2.5) should prompt prescription of a chest CT as it could reveal essential lesions that influence further management.

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Section: Introductionmentioning

confidence: 99%

Correlation Between Neutrophil-Lymphocyte Ratio, Platelets-Lymphocyte Ratio, and High-Resolution CT in Patients with COVID-19

et al. 2023

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“…Coronaviruses (CoV) belong to the coronavirus genus of the coronaviridae family. All CoVs are pleomorphic RNA viruses containing crown-like peplomers of 80-160 nm in size (Yurdaisik 2020). The RNA genomes is up to 32 kb of positive-sense RNA (Denison et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of liver stiffness using ultrasonic shear wave elastography in patients with COVID-19 induced pneumonia

Meng

et al. 2023

Can. J. Physiol. Pharmacol.

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In patients with COVID-19-induced pneumonia, shear wave elasticity (SWE) was used to assess liver stiffness. This study included 48 cases of COVID-19-induced pneumonia and 48 cases of normal physical examination. Basic and clinical data, including aspartate aminotransferase, were evaluated (AST). Color ultrasonography was used to test the liver's shear wave elasticity. A biopsy of the liver was also performed. In patients with COVID-19-induced pneumonia, AST and ALT levels were higher than in the control group. Liver SWE showed that liver stiffness is hard (8.745±0.2104) compared with control group (7.386±0.1521)(P<0.0001). Pathological biopsy showed that liver inflammation accounted for 89.58%, steatosis accounted for 81.25%, necrosis accounted for 10.42%, and fibrosis accounted for 33.33% in patients with COVID-19 induced pneumonia. ROC curve analysis showed that the SWE is highly sensitive and specific for the diagnosis of liver inflammation and steatosis. The sensitivity was 88.76%, and the specificity was 77.01% for the evaluation of liver inflammation. For steatosis, the sensitivity was 90.20%, and the specificity was 78.40%. The SWE of liver is useful to assess liver function and pathological status in COVID-19 patients.

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“…Various diagnostic methods have been proposed to provide a rapid response in the combat against the pandemic, each of them having a different degree of specificity and based on different target molecules from SARS-CoV-2 or the body in response to infection [ 21 , 22 ]. These methods include molecular and serological tests [ 23 ], as well as clinical tests, such as computed tomography (CT) [ 24 ], and each approach has its own advantages and shortcoming. Thus, the diagnostic methods present different performances depending on the type of the test and the stage of the disease, among other factors [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

The Main Molecular and Serological Methods for Diagnosing COVID-19: An Overview Based on the Literature

Machado

Hodel

Barbosa-Júnior

et al. 2020

Viruses

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Diagnostic tests have been considered as the main alternative for the control of coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as a correct diagnosis allows for decision making when facing the disease, particularly as there is a lack of effective therapeutic protocols and vaccines. Thus, in this review, we summarized the main diagnostic approaches currently available for the diagnosis of SARS-CoV-2 infection in humans based on studies available in article databases. The tests can be organized into two main categories: nucleic acid-based tests, recommended for the initial detection of the virus, and serological tests, recommended for assessing the disease progression. The studies have shown that the performance of diagnostic methods depends on different factors, such as the type of samples and the characteristics of each assay. It was identified that the positivity of the tests is mainly related to the onset of symptoms. We also observed that point-of-care diagnoses are considered as one of the main trends in this area, due to the low-cost and simplicity of the assay; however, the analytical performance must be critically analyzed. Thus, the COVID-19 pandemic has highlighted the critical role of diagnostic technologies in the control of infectious diseases.

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Effectiveness of Computed Tomography in the Diagnosis of Novel Coronavirus-2019

Cited by 8 publications

References 25 publications

Correlation Between Neutrophil-Lymphocyte Ratio, Platelets-Lymphocyte Ratio, and High-Resolution CT in Patients with COVID-19

Correlation Between Neutrophil-Lymphocyte Ratio, Platelets-Lymphocyte Ratio, and High-Resolution CT in Patients with COVID-19

Evaluation of liver stiffness using ultrasonic shear wave elastography in patients with COVID-19 induced pneumonia

The Main Molecular and Serological Methods for Diagnosing COVID-19: An Overview Based on the Literature

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