Effectiveness of brief alcohol interventions for general practice patients with problematic drinking behavior and comorbid anxiety or depressive disorders

Grothues, Janina; Bischof, Gallus; Reinhardt, Susa; Meyer, Christian; John, Ulrich; Rumpf, Hans‐Jürgen

doi:10.1016/j.drugalcdep.2007.11.015

Cited by 41 publications

(35 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Whereas the relapse rates for alcoholic patients without co-morbid disorders may be about 40%, these rates jump to about 69% or 77% for alcoholics with anxiety or the combination of anxiety and depressive disorders, respectively (Driessen et al, 2001). Although manifestation of these symptoms in alcoholics may facilitate seeking of treatment for alcoholism, they are general indicators of poorer outcomes (Kendall and Clarkin, 1992;Grothues et al, 2008;Lejoyeux et al, 2008). Hence, treatment of alcoholism may be improved by addition of pharmacological treatments for anxiety and/or depression.…”

Section: Introductionmentioning

confidence: 99%

Desipramine blocks alcohol-induced anxiety- and depressive-like behaviors in two rat strains☆

Getachew¹,

Hauser²,

Taylor³

et al. 2008

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Epidemiological studies indicate significant co-morbid expression of alcoholism, anxiety, and depression. These symptoms are often under-diagnosed and under-treated and can worsen prognostic and treatment outcome for alcoholism. Nonetheless, a causal relationship between alcoholism and these conditions is yet to be established. In this study we sought to determine the effects of daily alcohol administration on the indices of anxiety and depression in two rat strains, one of which exhibits inherent depressive-like characteristics. Moreover, it was of relevance to examine the effects of a clinically useful antidepressant on alcohol-induced behavioral changes. Wistar-Kyoto (WKY) rats derived from Wistar stock show low levels of locomotor activity in an open field and high levels of immobility in the forced swim test (FST) which is considered a measure of their helplessness and hence are considered a putative animal model of depression. Adult female WKY and Wistar rats were exposed for 3 hrs daily to 95% ethanol vapor to achieve a mean blood alcohol level (BAL) of approximately 150 mg/dL. Controls were exposed to air in similar inhalation chambers. Sixteen to 18 hrs following 7 or 14 days of exposure to alcohol, locomotor activity (LCA) in open field, duration of time spent in the open arm of the elevated plus-maze (EPM), reflective of anxiety-like behavior and immobility in FST were evaluated. Alcohol exposure for 7 or 14 days reduced LCA only in Wistar rats but enhanced FST immobility in both strains at both time points. Only 14 day alcohol exposure reduced EPM open arm time in both WKY and Wistar rats. Daily treatment with desipramine (8 mg/kg) blocked all the changes induced by alcohol in both strains. Thus, subchronic (7 day) exposure to alcohol induces depressive-like characteristics in Wistar rats and exacerbates that of WKY rats. Chronic (14 day) exposure, however, also induces an anxiety-like effect in both strains. The depressive-and anxietylike behaviors induced by alcohol were blocked by daily treatment with a tricyclic antidepressant. It may be suggested that prophylactic treatment of alcoholics with an antidepressant prior to detoxification may improve treatment outcome for alcoholism.

show abstract

Section: Introductionmentioning

confidence: 99%

Desipramine blocks alcohol-induced anxiety- and depressive-like behaviors in two rat strains☆

Getachew¹,

Hauser²,

Taylor³

et al. 2008

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

show abstract

“…Besides learning and memory impairment, emotional changes have also been frequently reported in alcoholics (Grothues et al, 2008;Haynes et al, 2008) and in rodents submitted to ethanol consumption (Cabral et al, 2007;Läck, Diaz, Chappell, DuBois, & McCool, 2007). In addition, emotional tone is clearly relevant in learning and memory processes (for a review see McGaugh, 2006;Roozendaal, Barsegyan, & Lee, 2008).…”

Section: Introductionmentioning

confidence: 99%

Intermittent ethanol binge exposure impairs object recognition but spares contextual and tone fear memory in adolescent rats.

Schaaffhausen¹,

Oliveira²,

Carvalho³

et al. 2009

Psychology & Neuroscience

View full text Add to dashboard Cite

Adolescent brain development seems to be important for the maturation of brain structures and behavior. Intermittent binge ethanol drinking is common among adolescents, and this type of drinking can induce brain damage and cognitive deficits. In addition, emotional changes are frequently seen in alcoholics and rodents treated with ethanol. Considering the close relation between emotional arousal and cognitive responses, the present work investigates if intermittent ethanol binge exposure could differentially alter the performance of adolescent rats in aversive and non-aversive motivated tests. Male adolescent rats were submitted to ethanol treatment (2.5 or 5.0 g/Kg, o.a.) at 48-h intervals over postnatal day (PND) 30 to 60. Control animals were exposed to a similar administration protocol with saline administration. At PND61-PND63 animals were submitted to one-trial object recognition or contextual and tone fear conditioning paradigms. Binge ethanol drinking (at both 2.5 and 5.0 g/Kg) did not change freezing response in the contextual and tone fear conditioning. However, all doses impaired recognition rates 24h after training in object recognition test. In addition, despite a diminution of horizontal locomotion in the open field (only for the 5.0 g/Kg dose), no difference was detected regarding time in immobility, time in grooming and number of rearing in this paradigm. The present results show that the cognitive impairment resulting from intermittent binge ethanol exposure has a negative correlation with learning-associated emotional arousal Keyword: ethanol, binge drinking, adolescent rats, learning and memory, emotional arousal.

show abstract

“…Em apenas três artigos da amostra a IB não foi efetiva: os pacientes com comorbidades não foram beneficiados com a técnica (20) ; autores obtiveram melhores resultados de tratamento quando empregaram o aconselhamento padrão, ou seja, a prática de IB não surtiu efeitos superiores à estratégia já empregada; a IB não foi eficaz porque os pacientes já estavam internados, e, consequentemente, abstinentes de álcool (25) .…”

Section: Discussionunclassified

Efetividade da intervenção breve para o uso abusivo de álcool na atenção primária: revisão sistemática

et al. 2013

View full text Add to dashboard Cite

420Rev Bras Enferm, Brasília 2013 mai-jun; 66(3): 420-8. REVISãOEfetividade da intervenção breve para o uso abusivo de álcool na atenção primária: revisão sistemática RESUMO A pesquisa identifi cou estudos clínicos acerca das intervenções breves para o uso abusivo de álcool e analisou a efi cácia dos aconselhamentos para os consumidores. Estudo bibliográfi co sistemático que utilizou artigos publicados no período de 1997 a 2010. Os achados mostraram que a estratégia de intervenção breve é efetiva na redução da frequência e quantidade de álcool, com melhores resultados quando aplicada na atenção primária. Todos os profi ssionais da área da saúde obtêm bons resultados com o manejo dessa terapia. Não foi possível defi nir se a estratégia é mais efi caz se aplicada em bebedores de uso nocivo ou em crônicos, uma vez que a intervenção depende da mobilização de recursos motivacionais do paciente e de mudanças de atitude relacionadas ao consumo de álcool. Descritores: Álcool; Intervenção Breve; Atenção Primária; Tratamento, Efetividade. ABTRACTThe research identifi ed clinical studies on the brief interventions for the abusive use of alcohol and analyzed the effectiveness of professional advises proposed to alcohol consumers. The systematic bibliographical study was based on articles published during the period of 1997 to 2010. Brief intervention strategy is effective in the reduction on the frequency and amount of alcohol use, with better results when the strategy is applied to the primary attention situations. All professionals obtained good results using this therapy. It was not possible to determine if the strategy is most effective when applied to harmful drinkers or to chronic drinkers, since the intervention also depends on the patient's availability of motivational resources and on changes in attitude regarding the abusive use of alcohol. Key words: Alcohol; Brief Intervention; Basic Attention; Treatment; Effectiveness. RESUMENLa encuesta identifi có estudios clínicos sobre intervenciones breves para el abuso de alcohol y analizado la efi cacia de la orientación a los consumidores. Estudio sistemático utilizó la literatura publicada entre 1997 y 2010. Resultados mostraron que la estrategia de intervención breve es efectiva en la reducción de la frecuencia y la cantidad de alcohol, con mejores resultados cuando se utilizan para primaria. Todas atenciones en el área de la salud han tenido buenos resultados con la gestión de esta terapia. No se puede establecer la estrategia es más efi caz si se aplica en los bebedores de abuso de alcohol o crónica, ya que la intervención depende de la movilización de los cambios motivacionales y actitudinales del paciente relacionados con el consumo de alcohol.

show abstract

Effectiveness of brief alcohol interventions for general practice patients with problematic drinking behavior and comorbid anxiety or depressive disorders

Cited by 41 publications

References 22 publications

Desipramine blocks alcohol-induced anxiety- and depressive-like behaviors in two rat strains☆

Desipramine blocks alcohol-induced anxiety- and depressive-like behaviors in two rat strains☆

Intermittent ethanol binge exposure impairs object recognition but spares contextual and tone fear memory in adolescent rats.

Efetividade da intervenção breve para o uso abusivo de álcool na atenção primária: revisão sistemática

Contact Info

Product

Resources

About