Effectiveness of Bone Marrow Biopsy for the Diagnosis of Pyrexia of Unknown Cause

Abstract

Background: Diagnosis of fever of unidentified cause remains challenging despite the availability of modern diagnostic techniques. Pyrexia of Unknown Origin (PUO) may result from various etiologies, among which infectious diseases are largely responsible. Many diagnostic approaches are currently applied. A detailed history with a complete general physical examination followed by baseline investigations with other specific tests like imaging, microbiological tests, and biopsies is employed to diagnose PUO. This study was designed for the evaluation and effectiveness of bone marrow biopsy in the identification of PUO and highlighted the existing spectrum of diseases involved in PUO.