Effectiveness of Bone Graft for an Alveolar Defect on Adjacent Second Molar After Impacted Mandibular Third Molar Extraction

Ku, Jeong-Kui; Jeong, Yeong Kon

doi:10.1016/j.joms.2020.11.030

Cited by 10 publications

(10 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…27 Compared with a collagen-sponge group, supplemental use of recombinant human bone morphogenetic protein 2 with bone graft material resulted in superior bone gain on the distal surfaces of second mandibular molars following third molar extraction. 28 A recently published systematic review and meta-analysis supported the use of platelet-rich fibrin following extraction and reported a faster wound-healing rate and lesser postoperative complications. 29 The application of readily available agents such as pre-medicated collagen sponges may present a convenient strategic option to supplement readily successful biomaterials for regenerative therapies.…”

Section: Discussionmentioning

confidence: 97%

Application of pre-medicated collagen sponges with regenerative biomaterials for management of an infected extraction socket

Sayed

2022

Preprint

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 97%

Application of pre-medicated collagen sponges with regenerative biomaterials for management of an infected extraction socket

Sayed

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…On the cross-sectional view of CBCT, a vertical reference line was the distal root surface of the second molar. The bony defect was measured based on the exposure of the second molar from the CEJ of M2 [ 10 ]. The specific threshold value (370–3071 Hounsfield units for bone demonstration) was reconstructed for measurement [ 9 ].…”

Section: Methodsmentioning

confidence: 99%

“…Patients with other teeth to be extracted as well, such as the maxillary third molar, underwent grafting immediately after the third mandibular extraction using pre-manufactured Auto-DDM. Our surgery protocol followed that of a previous study [ 10 ]. Briefly, after routine draping and local anesthesia (Lidocaine HCl, Huons, Seongnam-Si, Republic of Korea), an incision was made following the operculectomy protocol, and the third molar was extracted using a high-speed 2.0-mm round burr.…”

Section: Methodsmentioning

confidence: 99%

“…However, they assessed bone healing at M2 with 3D rather than 2D measurement techniques, which analyzed bone density, and obtained different results from actual bone healing on computed tomography (CT) [ 9 ]. In 2021, Ku and Jeong reported on the use of CT to measure bone healing at the distal root of M2 after M3 extraction and found that demineralized bone matrix (DBM) enriched with recombinant human bone morphogenetic protein-2 (rhBMP-2) led to significant improvements compared to a collagen plug [ 10 ]. As findings remain controversial due to the cost-effectiveness of using rhBMP-2, an efficient bone graft material for M3 extractions still needs to be developed.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Autogenous Demineralized Dentin Matrix on Mandibular Second Molar after Third Molar Extraction: Retrospective Study

Kim

et al. 2022

JFB

Self Cite

View full text Add to dashboard Cite

The purpose of this retrospective study was to evaluate bone healing after autogenous demineralized dentin matrix (DDM) grafts, focusing on the distal root of the mandibular second molar after the extraction of the third. We included retrospective data from 20 patients who had undergone molar extractions (15 male, 41.9 ± 12.0 years) between January 2020 and September 2022 and had DDM grafts implanted on the extraction socket, immediately (“immediate graft”) or 6 weeks (“delayed graft”) after the first surgery without primary closure. Patients who underwent grafting on only one side were used as the control group (n = 4). Bone defects at the mandibular second molar were measured preoperatively and 4 months after the graft surgery using cone-beam computed tomography (CBCT). Improvement of bone defect (i.e., the change in the bony defect pre- vs. postoperatively) was compared between the control and graft groups using the Wilcoxon Signed Rank test, and the difference between immediate and delayed grafts was analyzed with the Mann-Whitney U test. Complications such as infections or graft failure did not occur. Although pre-operative defects were smaller in the control than in the graft group (2.98 ± 1.77 and 10.02 ± 3.22 mm, p = 0.001), post-operative defects were similar in both (2.12 ± 0.59 and 2.29 ± 1.67 mm, respectively). The improvement ratio was not statistically significant in the control group (22.68 ± 15.36%) but a difference was observed in the graft group (76.70 ± 15.36%, p = 0.001). The amount of improvement of bone defect was not affected by graft timing or patient sex. In conclusion, DDM can improve bone defect at the distal aspect of the mandibular second molar after third molar extraction.

show abstract

“…Tooth extractions commonly lead to further bone defects, especially in the anterior region of the maxilla where the cortical bone is thinner [ 2 ]. Alveolar bone retrieval procedures, such as odontectomies, also carry a risk of alveolar bone defects [ 3 ]. Excessive orthodontic pressure due to orthodontic treatment is another risk factor [ 4 ] as are pathological processes, such as periodontitis [ 5 ] and cleft lip and palate [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Cytokine and Bone Protein Expression by Ellagic Acid-Hydroxyapatite in Bone Remodelling Model

Primasari

Nirwana

Budi

et al. 2022

The Scientific World Journal

View full text Add to dashboard Cite

Objective. Ellagic acid, a phenolic compound with anti-inflammatory potential, can be used to accelerate the bone healing process and affect human health, while hydroxyapatite is the most commonly used bone graft material. Using a combination of the two materials results in reduced inflammation and increased osteogenesis. This study aimed to determine the effects of combining ellagic acid and hydroxyapatite in bone marker remodelling by analysing the expression of tumour necrosis factor-α (TNF-α), interleukin 10 (IL-10), bone morphogenetic 4 protein (BMP-4), and osteopontin (OPN). Methods. Thirty Wistar rats were used in the study. A defect was created in each animal’s femur using a low-speed diamond bur. In the control group, the bone was then treated with polyethylene glycol (PEG). In one of the other groups, the bone was treated with hydroxyapatite, and in the other, with ellagic acid-hydroxyapatite. The femur was biopsied 7 days after the procedure and again 14 days after the procedure, and an indirect immunohistochemical (IHC) examination was performed for TNF-α, IL-10, BMP-4, and OPN expression. Results. The ellagic acid-hydroxyapatite decreased TNF-α expression in the bone tissue after 7 days and again after 14 days ( p < 0.05). On the other hand, it increased IL-10, BMP-4, and OPN expression ( p < 0.05) during the same time periods. Conclusion. Ellagic acid-hydroxyapatite plays a role in bone marker remodelling by decreasing the expression of TNF-α and increasing the expression of IL-10, BMP-4, and OPN. This hydroxyapatite combination can therefore be recommended for use as bone graft material.

show abstract

Effectiveness of Bone Graft for an Alveolar Defect on Adjacent Second Molar After Impacted Mandibular Third Molar Extraction

Cited by 10 publications

References 18 publications

Application of pre-medicated collagen sponges with regenerative biomaterials for management of an infected extraction socket

Application of pre-medicated collagen sponges with regenerative biomaterials for management of an infected extraction socket

Impact of Autogenous Demineralized Dentin Matrix on Mandibular Second Molar after Third Molar Extraction: Retrospective Study

The Cytokine and Bone Protein Expression by Ellagic Acid-Hydroxyapatite in Bone Remodelling Model

Contact Info

Product

Resources

About