Impact of Autogenous Demineralized Dentin Matrix on Mandibular Second Molar after Third Molar Extraction: Retrospective Study

Abstract

The purpose of this retrospective study was to evaluate bone healing after autogenous demineralized dentin matrix (DDM) grafts, focusing on the distal root of the mandibular second molar after the extraction of the third. We included retrospective data from 20 patients who had undergone molar extractions (15 male, 41.9 ± 12.0 years) between January 2020 and September 2022 and had DDM grafts implanted on the extraction socket, immediately (“immediate graft”) or 6 weeks (“delayed graft”) after the first surgery without primary closure. Patients who underwent grafting on only one side were used as the control group (n = 4). Bone defects at the mandibular second molar were measured preoperatively and 4 months after the graft surgery using cone-beam computed tomography (CBCT). Improvement of bone defect (i.e., the change in the bony defect pre- vs. postoperatively) was compared between the control and graft groups using the Wilcoxon Signed Rank test, and the difference between immediate and delayed grafts was analyzed with the Mann-Whitney U test. Complications such as infections or graft failure did not occur. Although pre-operative defects were smaller in the control than in the graft group (2.98 ± 1.77 and 10.02 ± 3.22 mm, p = 0.001), post-operative defects were similar in both (2.12 ± 0.59 and 2.29 ± 1.67 mm, respectively). The improvement ratio was not statistically significant in the control group (22.68 ± 15.36%) but a difference was observed in the graft group (76.70 ± 15.36%, p = 0.001). The amount of improvement of bone defect was not affected by graft timing or patient sex. In conclusion, DDM can improve bone defect at the distal aspect of the mandibular second molar after third molar extraction.

Demineralized dentin matrix for bone regeneration in dentistry: A critical update

“…However, Kim et al also described placement dental implant concurrently with GBR ( Kim et al, 2016 ). Kim et al, 2023 and Pang et al, 2016 both described similar outcomes following placement of DDM in extraction sockets for socket preservation ( Kim et al, 2022 ) and ( Pang et al, 2017 ). Meanwhile, two studies described using DDM for sinus floor augmentation ( Minamizato et al, 2018 , Umebayashi et al, 2020 ).…”

“… Fernandes et al, 2020 Rats ( n = 24) EDTA Extraction socket preservation Blood clot hDDM 21 days Higher number of trabeculae with hDDM. Kim et al, 2022 Rabbits ( n = 12) H 2 O 2 Calvaria defect fill hDDM/PRP hDDM/rhBPM-2 DDM No treatment 8 weeks The DDM/rhBMP-2 group demonstrated a higher degree of new bone formation. formation and calcification, and the lamellae of bone matrix.…”

“…The literature search initially identified 23 studies (16 animal studies ( Copelli et al, 2021 , De Oliveira et al, 2013 , Elkady et al, 2023 , Fernandes et al, 2020 , Gomes et al, 2016 , Kabir et al, 2017 , Kim et al, 2021 , Kim et al, 2017 , Koga et al, 2016 , Ku et al, 2022 , Moraes et al, 2022 , Nam et al, 2016 , Qin et al, 2015 , Tanoue et al, 2018 , Um et al, 2016 , Zhu et al, 2021 ) and 7 clinical reports ( Kanazirski and Kanazirska, 2022 , Kim et al, 2022 , Kim et al, 2016 , Minamizato et al, 2018 , Murata et al, 2022 , Pang et al, 2017 , Umebayashi et al, 2020 ). These are summarized and critically appraised below in Table 1 , Table 2 .…”

“…Four of the clinical studies were case reports or case series ( Kanazirski and Kanazirska, 2022 , Kim et al, 2016 , Murata et al, 2022 , Umebayashi et al, 2020 ). One study reported on a randomized clinical trial ( Pang et al, 2017 ), one study was of a prospective cohort ( Minamizato et al, 2018 ) and another was a retrospective cohort study ( Kim et al, 2022 ). The number of patients treated ranged from 1 to 24, and these were followed up for between 3 months and 5 years.…”

Osseous defects of radicular cysts after cystectomy repairing with autogenous tooth sticky bone graft in the maxillary aesthetic area

“…The limitations of this study and the alveolar bone repair material itself should be acknowledged. Although autogenous tooth sticky bone graft has distinct advantages, such as fast osteogenesis, a very low bone resorption rate and low cost, it still cannot be the number one choice for oral surgical grafting [15,25,26]. First, it is not readily available.…”