Effectiveness of an individually-tailored computerised CBT programme (Deprexis) for depression: A meta-analysis

Twomey, Conal; O’Reilly, Gary; Meyer, Björn

doi:10.1016/j.psychres.2017.06.081

Cited by 90 publications

(82 citation statements)

References 25 publications

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“…While the efficacy of Deprexis has been evaluated favorably in the treatment of various depressed samples, we have little knowledge about its acceptance and efficacy in blended care approaches [12]. A recent trial with 1,013 participants [51] in different clinical and nonclinical settings demonstrated the effectiveness of Deprexis as an add-on to usual care, with a between-group effect size concerning depressive symptoms (PHQ-9) of d = 0.39 posttreatment (3 months) and d = 0.32 at the 6-month follow-up compared to care as usual alone (psychological and/or pharmacological treatments).…”

Section: Discussionmentioning

confidence: 99%

“…Deprexis is an interactive internet-based self-help program which does not necessarily require therapist support. A recent meta-analysis [12] based on 8 studies demonstrated posttreatment effectiveness for depressive symptoms with a medium effect size of d = 0.54 (95% CI: 0.39-0.69). Findings on the applicability of online self-help for primary care patients have been mixed, especially when offered in usual care settings [13].…”

Section: Introductionmentioning

confidence: 99%

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Online Self-Help as an Add-On to Inpatient Psychotherapy: Efficacy of a New Blended Treatment Approach

Zwerenz¹,

Becker²,

Knickenberg³

et al. 2017

Psychother Psychosom

107

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Background: Depression is one of the most frequent and costly mental disorders. While there is increasing evidence for the efficacy of online self-help to improve depression or prevent relapse, there is little evidence in blended care settings, especially combined with inpatient face-to-face psychotherapy. Therefore, we evaluated whether an evidence-based online self-help program improves the efficacy of inpatient psychotherapy. Methods: A total of 229 depressed patients were randomly allocated either to an online self-help program (intervention group [IG]; Deprexis) or an active control group (CG; weekly online information on depression) in addition to inpatient psychodynamic psychotherapy. Both groups had access to their respective experimental intervention for 12 weeks, regardless of inpatient treatment duration. Reduction of depressive symptoms, as measured with the Beck Depression Inventory-II, was the primary outcome at the end of the intervention (T2). Results: Depressive symptoms were statistically significantly lower in the IG compared to the active CG at T2 with a moderate between-group effect size of d = 0.44. The same applied to anxiety (d = 0.33), quality of life (d = 0.34), and self-esteem (d = 0.38) at discharge from inpatient treatment (T1). No statistically significant differences were found regarding dysfunctional attitudes (d = 0.14) and work ability (d = 0.08) at T1. Conclusions: This is the first evidence for blended treatment combining online self-help with inpatient psychotherapy. The study opens new and promising avenues for increasing the efficacy of inpatient psychotherapy. Future studies should determine how integration of online self-help into the therapeutic process can be developed further.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Online Self-Help as an Add-On to Inpatient Psychotherapy: Efficacy of a New Blended Treatment Approach

Zwerenz¹,

Becker²,

Knickenberg³

et al. 2017

Psychother Psychosom

107

View full text Add to dashboard Cite

show abstract

“…This report presents secondary analyses of data collected in a large multicenter randomized controlled trial, the EVIDENT study (Klein et al, 2013, which examined the effects of the Internet intervention deprexis (Twomey, O'Reilly, & Meyer, 2017) among mildly to moderately depressed adults. Participants were randomized (1:1) to one of the two conditions-(1) care as usual (CAU) or (2) CAU plus deprexis using an allocation schedule based on a computerized random numbers generator.…”

Section: Methodsmentioning

confidence: 99%

“…Deprexis consists of 10 modules covering content that is broadly consistent with CBT (e.g., cognitive modification, behavioral activation, acceptance and mindfulness, problem solving, and interpersonal skills), plus one introduction and one summary module (Twomey et al, 2017).…”

Section: Interventionmentioning

confidence: 99%

Impact and change of attitudes toward Internet interventions within a randomized controlled trial on individuals with depression symptoms

et al. 2018

Self Cite

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“…One promising intervention, called Deprexis, is an individually tailored, web-based treatment for depression that integrates evidence-based approaches including cognitive restructuring, problem-solving, behavioral activation, social skills training, as well as mindfulness and acceptance-based exercises (Meyer et al, 2009). A recent meta-analysis of randomized clinical trials supports the effectiveness of Deprexis for reducing depression compared with control conditions, with a medium effect size of g = .54 (Twomey, O'Reilly, & Meyer, 2017).…”

mentioning

confidence: 99%

Network analyses reveal which symptoms improve (or not) following an Internet intervention (Deprexis) for depression

Mullarkey¹,

Stein²,

Pearson³

et al. 2019

Depress Anxiety

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Background: Depression is a heterogeneous collection of symptoms. Prior metaanalyses using symptom sum scores have shown the Internet intervention, Deprexis, to be an efficacious treatment for depression. However, no prior research has investigated how Deprexis (or any other Internet intervention for depression) impacts specific symptoms of depression. The current study utilizes symptom-level analyses to examine which symptoms are directly, indirectly, or minimally influenced by treatment.Methods: Network analysis and mean-level approaches examined which symptoms, assessed by the Quick Inventory of Depression Symptoms, were affected by an 8week course of Deprexis compared with a waitlist in a nationally recruited sample from the United States (N = 295).Results: Deprexis directly improved the symptoms of sadness and indecision. Changes in these symptoms, in turn, was associated with a change in early insomnia, middle insomnia, self-dislike, fatigue, anhedonia, suicidality, slowness, and agitation. All of these symptoms (except for agitation and early insomnia) show decreases with Deprexis compared with a waitlist after correcting for multiple comparisons. Six additional symptoms, particularly the somatic symptoms, were not impacted by Deprexis compared with a waitlist.Conclusions: In this sample, the efficacy of Deprexis was due to its direct impact on sadness and indecision. Examining the treatment-related change in specific symptoms may facilitate a more nuanced understanding of how a treatment works compared with examining symptom sum scores. Symptom-level approaches may also identify symptoms that do not improve and provide important direction for future treatment development.

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Effectiveness of an individually-tailored computerised CBT programme (Deprexis) for depression: A meta-analysis

Cited by 90 publications

References 25 publications

Online Self-Help as an Add-On to Inpatient Psychotherapy: Efficacy of a New Blended Treatment Approach

Online Self-Help as an Add-On to Inpatient Psychotherapy: Efficacy of a New Blended Treatment Approach

Impact and change of attitudes toward Internet interventions within a randomized controlled trial on individuals with depression symptoms

Network analyses reveal which symptoms improve (or not) following an Internet intervention (Deprexis) for depression

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