Effectiveness of aldehyde disinfectant against the causative agents of tuberculosis in domestic animals and birds

Paliy, Anatoliy; Ishchenko, Katerina; Marchenko, Mykhailo; Дубін, Руслан Анатолійович

doi:10.15421/2018_283

Cited by 16 publications

(18 citation statements)

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“…In the external environment, many adverse conditions affect the pathogens and cause the death of microorganisms (Haruta & Kanno, 2015). However, all of these factors do not replace or preclude the use of disinfectants to completely disinfect contaminated objects (Paliy et al, 2018c;Palii et al, 2020;Takagi & Yagishita, 2020;Costard et al, 2009). High efficiency combined with simplicity and economy of operation promotes wide use of disinfection in animal husbandry and veterinary.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of acute toxicity of the "Orgasept" disinfectant

Kovalenko¹,

Пономаренко²,

Kukhtyn³

2020

Ukr J Ecol

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The purpose of the research was to study acute toxicity, irritating and sensitizing effects, biochemical and immunological parameters of animal blood after influence of "Orgasept" disinfectant, consisted from silver nanoparticles, benzalkonium chloride and lactic acid. To determine acute toxicity, 6 months old clinically healthy male rats (5 groups, six rats per each group) and female rats (5 groups, six per each group) with body weight of 180-200 g were used. We determined the average lethal dose (LD50) and the main parameters of acute toxicity after Orgasept rats administration in various dozes. We found that, at intra-gastrointestinal administration of Orgasept, the LD50 for male rats was 5000.0±43.0 mg/kg body weight and 5045.0±56.3 mg/kg for the females. We also registered that Orgasept does not have cumulative and sensitizing properties, does not show irritating effect, suppressive effect on growth and development of animals, and does not affect the hemopoiesis. We revealed that Orgasept demonstrated significant effect on nonspecific and specific factors of the organism's protection compared to the formaldehyde.

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Section: Introductionmentioning

confidence: 99%

Evaluation of acute toxicity of the "Orgasept" disinfectant

Kovalenko¹,

Пономаренко²,

Kukhtyn³

2020

Ukr J Ecol

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“…Today during disinfection when animal tuberculosis is declared, disinfectants, the active substance of which is glutaraldehyde, which interacts with the protein components of the membrane structures of bacterial cells, disrupting the processes of their synthesis and ultimately causing their death, are widely used (Chupakhin et al, 1987;Gutyj et al, 2017;Paliy et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Determination of acute toxicity of the ‘Bondarmin’ disinfectant

Bondarchuk

Paliy

Blazheyevskіy

2019

J. Vet. Med. Biotechnol. Biosafety

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In the article the results of the study of toxic effect of the designed disinfectant (active ingredient potassium peroxomonosulfate) on laboratory animals (mice) are presented. For the recent years a variety of scientific works both by domestic and by foreign scientists has been devoted to the study of different disinfectants’ toxicity. However today there is a number of issues that require more detailed studying and scientific justification. Among them the problem of toxic effects of disinfectants on the animal organism occupies a special place. The aim of our work was to study the toxic effect on the laboratory animals and to assess the acute toxicity (LD50) of the designed ‘Bondarmin’ disinfectant. Tests were carried out at the Laboratory of pharmacology and toxicology of the National University of Pharmacy (Kharkiv) and on the base of Educational and scientific laboratory of genetic and molecular research methods named after P. I. Verbitskiy in the Kharkiv State Zooveterinary Academy. Acute toxicity assessment (LD50) was carried out with intragastrointestinal administration of the designed drug to laboratory animals (mice). Changes in the internal organs of animals that were removed from the experiment for humane reasons and those who died after the experiment were detected by macroscopic examination. The lethality of laboratory animals after the intragastric administration of disinfectant was determined by the Prozorovskiy method The dynamic of changes in body weight of mice after the administration of disinfectant in high doses (from 1,500 to 3,500 mg/kg) was found out. The influence of the disinfectant on the mass coefficients of the internal organs of male mice after intragastric administration was evaluated. Toxic effect of the designed disinfectant ‘Bondarmin’, when using intragastric method of administration to laboratory animals (mice), according to the age and sexual index (LD50 = 2,702.40 ± 156.32 mg/kg), was established. Disinfectant ‘Bondarmin’ refers to IV toxicity class (low toxic substances).

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“…A number of disinfectants that contain different classes of chemical compounds as active substances have been developed and proposed for practical use, and they are recommended for use in different branches of industry (Zavgorodniy and Paliy, 2014;Paliy et al, 2015;Kovalenko, Paliy and Zagrebelniy, 2017;Rodionova and Paliy, 2017). www.jvmbbs.kharkov.ua It should be pointed out that the large-scale production of disinfectants and their introduction into practice is impossible without the preliminary laboratory assessment of their antimicrobial properties, the determination of the spectrum of their biocidal effect and physical, chemical and toxicological properties (Zavgorodniy et al, 2013;Paliy et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Virucidal properties of innovative disinfectant to Avian influenza virus and Newcastle disease virus

Stegniy

Paliy

Pavlichenko

et al. 2019

J. Vet. Med. Biotechnol. Biosafety

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The first and the main link in the system of prevention of the occurrence and distribution of avian influenza and Newcastle disease is monitoring and the effective prophylaxis of the above diseases. At the same time the conducting of disinfection of the objects of veterinary control is an important stage in the system of veterinary and sanitary measures. A number of disinfectants that contain different classes of chemical compounds as active substances have been developed and proposed for practical use. The large-scale production of disinfectants and their introduction into practice is impossible without the preliminary laboratory assessment of their antimicrobial properties, the determination of the spectrum of their biocidal effect and physical, chemical and toxicological properties. The aim of our work was to study the virucidal properties of a new aldehyde disinfectant using the test models of the viruses of Newcastle disease and avian influenza. The experiments to study virucidal properties of the disinfectant regarding the viruses of avian influenza and Newcastle disease have been carried out at the Department for Avian Diseases Study of the National Scientific Center ‘Institute of Experimental and Clinical Veterinary Medicine’ in accordance with the guidelines ‘Methods for determining and evaluating the safety and quality of disinfectants and disinfecting detergents used in the production, storage, transportation and sale of products of animal origin’ (Kotsiumbas et al., 2010). The determination of the virucidal properties of the disinfectant has been conducted in two stages: stage 1 — the determination of the virucidal activity of the product by the suspension method; stage 2 — determination of the virucidal activity of the product on test objects. As a result of the research conducted by the suspension method the presence of the virucidal properties of the innovative disinfectant (the mixture of quaternary ammonium compounds — 25%, glutar aldehyde — 11%, isopropanol, non-ionic surfactants) for the viruses of avian influenza and Newcastle disease has been determined. It has been found that the above preparation completely inactivated the infective properties of viruses when used in the concentration of 0.1%, with the interval of 30 minutes and in the concentration of 0.5% — 15-minute interval. It has been proved that the use of the disinfectant in 0.1% concentration for 30 minutes disinfected the test objects (wood, metal, tile, textile) that were contaminated by the pathogenic agents of avian influenza and Newcastle disease

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Effectiveness of aldehyde disinfectant against the causative agents of tuberculosis in domestic animals and birds

Cited by 16 publications

References 0 publications

Evaluation of acute toxicity of the "Orgasept" disinfectant

Evaluation of acute toxicity of the "Orgasept" disinfectant

Determination of acute toxicity of the ‘Bondarmin’ disinfectant

Virucidal properties of innovative disinfectant to Avian influenza virus and Newcastle disease virus

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