Effectiveness of a tailor-made weight loss intervention in primary care

Vos, Bastiaan C. de; Runhaar, Jos; Bierma-Zeinstra, Sita M A

doi:10.1007/s00394-013-0505-y

Cited by 27 publications

(28 citation statements)

References 26 publications

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“…The first was to be expected, since a high BMI is a predictor for greater weight loss (39,40). Probably, the higher prevalence of knees with a history of injury in the weight loss group was also linked to BMI; baseline BMI was significantly higher in subjects with a previously injured knee than in subjects without, and a history of injury was shown to have a nonsignificant effect on all outcome measures when adjusted for BMI at baseline (data not shown).…”

Section: Discussionmentioning

confidence: 95%

Prevention of Incident Knee Osteoarthritis by Moderate Weight Loss in Overweight and Obese Females

Runhaar

Vos

Middelkoop

et al. 2016

Arthritis Care & Research

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Objective. This study evaluated the effect of moderate weight loss on the incidence of knee osteoarthritis (OA) in middle-aged overweight and obese women, without clinical and radiologic knee OA at baseline. Methods. A total of 353 women (87%) with followup data available were selected from the Prevention of Knee Osteoarthritis in Overweight Females study, which evaluated the preventive effect of a diet and exercise intervention and of oral glucosamine sulfate on the incidence of knee OA. This was an exploratory proof-of-concept analysis, which compared the incidence of knee OA between women who reached the clinically relevant weight loss target of 5 kg or 5% of body weight after 30 months and those who did not reach this target. Results. The weight loss group showed a significantly lower incidence of knee OA according to the primary outcome measure, which was composed of the American College of Rheumatology criteria (clinical and radiographic), Kellgren/Lawrence grade ‡2, and joint space narrowing ‡1.0 mm (15% versus 20%; odds ratio 0.5, 95% confidence interval 0.3-0.9). Moreover, the weight loss also positively affected several health measures, such as blood glucose level, body fat percentage, and blood pressure. Conclusion. A reduction of ‡5 kg or 5% of body weight over a 30-month period reduces the risk for the onset of radiographic knee OA in middle-aged overweight and obese women. Because of the slow progression of the disease, a longer followup period will be necessary before the number of prevented cases of knee OA by moderate weight loss becomes clinically more relevant.

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Section: Discussionmentioning

confidence: 95%

Prevention of Incident Knee Osteoarthritis by Moderate Weight Loss in Overweight and Obese Females

Runhaar

Vos

Middelkoop

et al. 2016

Arthritis Care & Research

Self Cite

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“…This randomized controlled trial investigated the effects of a diet and exercise program and of oral glucosamine sulphate (double-blind and placebo-controlled) on incidence of knee OA, in a 2Â2 factorial design 11,12 . The PROOF study included middle-aged women (50e60 years) with a BMI !27.0 kg/m 2 , but free of clinical and radiographic knee OA at baseline.…”

Section: Methodsmentioning

confidence: 99%

Fibulin-3 fragments are prognostic biomarkers of osteoarthritis incidence in overweight and obese women

Runhaar

Sanchez

Taralla³

et al. 2016

Osteoarthritis and Cartilage

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Baseline fibulin-3 concentrations are associated with the incidence of clinical knee OA among middle-aged overweight and obese women. Therewith, they meet the criteria of a prognostic biomarker according to the BIPED biomarker classification for OA. Further validation of the fibulin-3 epitopes seems warranted in order to better distinguish subgroups of individuals at increased risk for knee OA development.

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“…A description of the study protocol can be found elsewhere [2,16]. In short, this 2.5-year follow-up study aimed to evaluate the preventive effect of a diet and exercise programme and oral glucosamine sulphate (double blind, placebo controlled) on the initiation of knee OA in a 2 Â 2 factorial design.…”

Section: Methodsmentioning

confidence: 99%

“…From a health perspective, weight loss would probably be more preferable as a preventive measure. However, given the challenge of adhering to a weight loss intervention and achieving weight loss in this population [16], counteracting malalignment might be an additional option in preventing the development of radiographic knee OA.…”

Section: Fig 1 Histogram Of Medial Anatomical Knee Anglesmentioning

confidence: 99%

Malalignment: a possible target for prevention of incident knee osteoarthritis in overweight and obese women

et al. 2014

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Objectives. The present study aims to investigate the associations between malalignment and incident knee OA after 2.5 years in a high-risk group of 333 middle-aged overweight women (BMI 5 27 kg/m 2 ) free of clinical and radiological knee OA at baseline.Methods. The primary outcome measure was the incidence of knee OA, defined as the incidence of radiographic knee OA (Kellgren and Lawrence grade 52), clinical knee OA (ACR criteria) or medial or lateral joint space narrowing (51.0 mm). Using generalized estimating equations, associations between valgus and varus alignment (compared with neutrally aligned knees) and the primary outcome measure and all its items separately were studied.Results. Neither varus-nor valgus-aligned knees had a significantly increased risk for incident knee OA according to the primary outcome measure. A significantly increased risk for the development of radiographic knee OA was found for varus-aligned knees [odds ratio (OR) 3.3, 95% CI 1.5, 7.3]. Valgus-aligned knees showed a borderline increased OR (2.8, 95% CI 1.0, 8.0) for the development of radiographic knee OA. No statistically significant effects were found for varus and valgus alignment on the incidence of clinical knee OA or medial or lateral joint space narrowing.Conclusion. Since this study was performed in a true target population, current data suggest that malalignment might be a target for the prevention of radiographic knee OA in overweight and obese women.

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Effectiveness of a tailor-made weight loss intervention in primary care

Cited by 27 publications

References 26 publications

Prevention of Incident Knee Osteoarthritis by Moderate Weight Loss in Overweight and Obese Females

Prevention of Incident Knee Osteoarthritis by Moderate Weight Loss in Overweight and Obese Females

Fibulin-3 fragments are prognostic biomarkers of osteoarthritis incidence in overweight and obese women

Malalignment: a possible target for prevention of incident knee osteoarthritis in overweight and obese women

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